Matches in SemOpenAlex for { <https://semopenalex.org/work/W1856496738> ?p ?o ?g. }
- W1856496738 endingPage "780" @default.
- W1856496738 startingPage "759" @default.
- W1856496738 abstract "The aggregation of specific proteins is hypothesized to underlie several degenerative diseases, which are collectively known as amyloid disorders. However, the mechanistic connection between the process of protein aggregation and tissue degeneration is not yet fully understood. Here, we review current and emerging strategies to ameliorate aggregation-associated degenerative disorders, with a focus on disease-modifying strategies that prevent the formation of and/or eliminate protein aggregates. Persuasive pharmacological and genetic evidence now supports protein aggregation as the cause of postmitotic tissue dysfunction or loss. However, a more detailed understanding of the factors that trigger and sustain aggregate formation and of the structure-activity relationships underlying proteotoxicity is needed to develop future disease-modifying therapies." @default.
- W1856496738 created "2016-06-24" @default.
- W1856496738 creator A5001513093 @default.
- W1856496738 creator A5001528017 @default.
- W1856496738 creator A5040261788 @default.
- W1856496738 creator A5070564223 @default.
- W1856496738 creator A5073572665 @default.
- W1856496738 creator A5081499831 @default.
- W1856496738 creator A5083999892 @default.
- W1856496738 date "2015-09-04" @default.
- W1856496738 modified "2023-10-01" @default.
- W1856496738 title "Targeting protein aggregation for the treatment of degenerative diseases" @default.
- W1856496738 cites W1481393922 @default.
- W1856496738 cites W1493986974 @default.
- W1856496738 cites W1494074009 @default.
- W1856496738 cites W1494494379 @default.
- W1856496738 cites W1501971533 @default.
- W1856496738 cites W1523693806 @default.
- W1856496738 cites W1532832054 @default.
- W1856496738 cites W1541950149 @default.
- W1856496738 cites W1553423283 @default.
- W1856496738 cites W1567490604 @default.
- W1856496738 cites W1584074575 @default.
- W1856496738 cites W1587588813 @default.
- W1856496738 cites W161538968 @default.
- W1856496738 cites W1619710608 @default.
- W1856496738 cites W1621971853 @default.
- W1856496738 cites W1675105744 @default.
- W1856496738 cites W1693283493 @default.
- W1856496738 cites W1823419340 @default.
- W1856496738 cites W187210528 @default.
- W1856496738 cites W1918115329 @default.
- W1856496738 cites W1921787609 @default.
- W1856496738 cites W1928837524 @default.
- W1856496738 cites W1964010087 @default.
- W1856496738 cites W1965095016 @default.
- W1856496738 cites W1965275873 @default.
- W1856496738 cites W1967138582 @default.
- W1856496738 cites W1967144890 @default.
- W1856496738 cites W1967464880 @default.
- W1856496738 cites W1967549235 @default.
- W1856496738 cites W1967773653 @default.
- W1856496738 cites W1968925833 @default.
- W1856496738 cites W1969175350 @default.
- W1856496738 cites W1969994843 @default.
- W1856496738 cites W1970500983 @default.
- W1856496738 cites W1971054145 @default.
- W1856496738 cites W1971108880 @default.
- W1856496738 cites W1971840315 @default.
- W1856496738 cites W1971855284 @default.
- W1856496738 cites W1972373816 @default.
- W1856496738 cites W1972417329 @default.
- W1856496738 cites W1973897761 @default.
- W1856496738 cites W1976204255 @default.
- W1856496738 cites W1976981142 @default.
- W1856496738 cites W1977150379 @default.
- W1856496738 cites W1979704176 @default.
- W1856496738 cites W1980115442 @default.
- W1856496738 cites W1981458288 @default.
- W1856496738 cites W1982653993 @default.
- W1856496738 cites W1982796475 @default.
- W1856496738 cites W1982797857 @default.
- W1856496738 cites W1984543278 @default.
- W1856496738 cites W1984636918 @default.
- W1856496738 cites W1984766678 @default.
- W1856496738 cites W1985334202 @default.
- W1856496738 cites W1985570437 @default.
- W1856496738 cites W1986792544 @default.
- W1856496738 cites W1987644496 @default.
- W1856496738 cites W1987751618 @default.
- W1856496738 cites W1987781655 @default.
- W1856496738 cites W1989150559 @default.
- W1856496738 cites W1989208474 @default.
- W1856496738 cites W1990665640 @default.
- W1856496738 cites W1990752558 @default.
- W1856496738 cites W1990986671 @default.
- W1856496738 cites W1991241547 @default.
- W1856496738 cites W1991462232 @default.
- W1856496738 cites W1991870666 @default.
- W1856496738 cites W1994284091 @default.
- W1856496738 cites W1994772574 @default.
- W1856496738 cites W1994877692 @default.
- W1856496738 cites W1995144380 @default.
- W1856496738 cites W1995191747 @default.
- W1856496738 cites W1995319721 @default.
- W1856496738 cites W1995520063 @default.
- W1856496738 cites W1996320585 @default.
- W1856496738 cites W1997524825 @default.
- W1856496738 cites W1997525726 @default.
- W1856496738 cites W2000274949 @default.
- W1856496738 cites W2000917982 @default.
- W1856496738 cites W2002439304 @default.
- W1856496738 cites W2002615785 @default.
- W1856496738 cites W2002746220 @default.
- W1856496738 cites W2003618511 @default.
- W1856496738 cites W2005072201 @default.
- W1856496738 cites W2005483591 @default.
- W1856496738 cites W2006192061 @default.