FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W185659144> ?p ?o ?g. }

• W185659144 endingPage "375" @default.
• W185659144 startingPage "367" @default.
• W185659144 abstract "Recently we demonstrated that the co-expressed coronavirus membrane proteins have the capacity to assemble viral envelopes which are similar to normal virus particles in dimensions and appearance, and which can form independent of a nucleocapsid (Vennema et al., 1996). For the formation of these particles only the M and the E protein are required; the S protein is dispensable but is incorporated when present. As we illustrate here, this virus-like particle assembly system is an ideal tool to study the interactions between the essential assembly partners M and E in molecular detail. Taking a mutagenetic approach we demonstrate that envelope assembly is critically sensitive to changes in the primary structure of both terminal domains of the M protein. The effects were most dramatically observed after mutation of the carboxy-terminal domain where the deletion of just one single amino acid at the extreme terminus abolished particle formation almost completely. But also some subtle mutations in the amino-terminal domain were severely inhibitory to the assembly process. Interestingly, mutant M proteins that were themselves incompetent to support particle formation appeared to inhibit, in a concentration dependent manner, the assembly of particles by wild-type M and E protein." @default.
• W185659144 created "2016-06-24" @default.
• W185659144 creator A5000266713 @default.
• W185659144 creator A5032673596 @default.
• W185659144 creator A5075787110 @default.
• W185659144 date "1998-01-01" @default.
• W185659144 modified "2023-10-06" @default.
• W185659144 title "Coronavirus Envelope Assembly is Sensitive to Changes in the Terminal Regions of the Viral M Protein" @default.
• W185659144 cites W1261247840 @default.
• W185659144 cites W1525285670 @default.
• W185659144 cites W1582853114 @default.
• W185659144 cites W1762245052 @default.
• W185659144 cites W1831715993 @default.
• W185659144 cites W1851383444 @default.
• W185659144 cites W1966553729 @default.
• W185659144 cites W1994803296 @default.
• W185659144 cites W2008457983 @default.
• W185659144 cites W2033577629 @default.
• W185659144 cites W2052780110 @default.
• W185659144 cites W2062660708 @default.
• W185659144 cites W2093617423 @default.
• W185659144 cites W2095988962 @default.
• W185659144 cites W2171799143 @default.
• W185659144 cites W2287048591 @default.
• W185659144 cites W93967102 @default.
• W185659144 doi "https://doi.org/10.1007/978-1-4615-5331-1_48" @default.
• W185659144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9782305" @default.
• W185659144 hasPublicationYear "1998" @default.
• W185659144 type Work @default.
• W185659144 sameAs 185659144 @default.
• W185659144 citedByCount "6" @default.
• W185659144 countsByYear W1856591442013 @default.
• W185659144 countsByYear W1856591442015 @default.
• W185659144 countsByYear W1856591442020 @default.
• W185659144 countsByYear W1856591442022 @default.
• W185659144 crossrefType "book-chapter" @default.
• W185659144 hasAuthorship W185659144A5000266713 @default.
• W185659144 hasAuthorship W185659144A5032673596 @default.
• W185659144 hasAuthorship W185659144A5075787110 @default.
• W185659144 hasBestOaLocation W1856591441 @default.
• W185659144 hasConcept C104317684 @default.
• W185659144 hasConcept C12554922 @default.
• W185659144 hasConcept C134306372 @default.
• W185659144 hasConcept C14053116 @default.
• W185659144 hasConcept C142724271 @default.
• W185659144 hasConcept C143065580 @default.
• W185659144 hasConcept C144292202 @default.
• W185659144 hasConcept C159047783 @default.
• W185659144 hasConcept C167625842 @default.
• W185659144 hasConcept C185592680 @default.
• W185659144 hasConcept C2522874641 @default.
• W185659144 hasConcept C2777648638 @default.
• W185659144 hasConcept C2779134260 @default.
• W185659144 hasConcept C3008058167 @default.
• W185659144 hasConcept C3018824666 @default.
• W185659144 hasConcept C33923547 @default.
• W185659144 hasConcept C36503486 @default.
• W185659144 hasConcept C47701112 @default.
• W185659144 hasConcept C501734568 @default.
• W185659144 hasConcept C515207424 @default.
• W185659144 hasConcept C524204448 @default.
• W185659144 hasConcept C55493867 @default.
• W185659144 hasConcept C57711820 @default.
• W185659144 hasConcept C71924100 @default.
• W185659144 hasConcept C86803240 @default.
• W185659144 hasConcept C95444343 @default.
• W185659144 hasConcept C97380033 @default.
• W185659144 hasConceptScore W185659144C104317684 @default.
• W185659144 hasConceptScore W185659144C12554922 @default.
• W185659144 hasConceptScore W185659144C134306372 @default.
• W185659144 hasConceptScore W185659144C14053116 @default.
• W185659144 hasConceptScore W185659144C142724271 @default.
• W185659144 hasConceptScore W185659144C143065580 @default.
• W185659144 hasConceptScore W185659144C144292202 @default.
• W185659144 hasConceptScore W185659144C159047783 @default.
• W185659144 hasConceptScore W185659144C167625842 @default.
• W185659144 hasConceptScore W185659144C185592680 @default.
• W185659144 hasConceptScore W185659144C2522874641 @default.
• W185659144 hasConceptScore W185659144C2777648638 @default.
• W185659144 hasConceptScore W185659144C2779134260 @default.
• W185659144 hasConceptScore W185659144C3008058167 @default.
• W185659144 hasConceptScore W185659144C3018824666 @default.
• W185659144 hasConceptScore W185659144C33923547 @default.
• W185659144 hasConceptScore W185659144C36503486 @default.
• W185659144 hasConceptScore W185659144C47701112 @default.
• W185659144 hasConceptScore W185659144C501734568 @default.
• W185659144 hasConceptScore W185659144C515207424 @default.
• W185659144 hasConceptScore W185659144C524204448 @default.
• W185659144 hasConceptScore W185659144C55493867 @default.
• W185659144 hasConceptScore W185659144C57711820 @default.
• W185659144 hasConceptScore W185659144C71924100 @default.
• W185659144 hasConceptScore W185659144C86803240 @default.
• W185659144 hasConceptScore W185659144C95444343 @default.
• W185659144 hasConceptScore W185659144C97380033 @default.
• W185659144 hasLocation W1856591441 @default.
• W185659144 hasLocation W1856591442 @default.
• W185659144 hasOpenAccess W185659144 @default.
• W185659144 hasPrimaryLocation W1856591441 @default.

• next