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• W1857029450 abstract "No AccessJournal of UrologyAdult Urology1 Feb 2016African-American Men with Gleason Score 3+3=6 Prostate Cancer Produce Less Prostate Specific Antigen than Caucasian Men: A Potential Impact on Active Surveillance Oleksandr N. Kryvenko, Raymond Balise, Nachiketh Soodana Prakash, and Jonathan I. Epstein Oleksandr N. KryvenkoOleksandr N. Kryvenko Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author , Raymond BaliseRaymond Balise Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Department of Biostatistics, University of Miami Miller School of Medicine, Miami, Florida More articles by this author , Nachiketh Soodana PrakashNachiketh Soodana Prakash Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author , and Jonathan I. EpsteinJonathan I. Epstein Departments of Pathology, Urology and Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.08.089AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We assess the difference in prostate specific antigen production between African-American and Caucasian men with Gleason score 3+3=6 prostate cancer. Materials and Methods: We measured tumor volume in 414 consecutive radical prostatectomies from men with National Comprehensive Cancer Network® low risk prostate cancer (348 Caucasian, 66 African-American) who had Gleason score 3+3=6 disease at radical prostatectomy. We then compared clinical presentation, pathological findings, prostate specific antigen, prostate specific antigen density and prostate specific antigen mass (an absolute amount of prostate specific antigen in patient’s circulation) between African-American and Caucasian men. The t-test and Wilcoxon rank sum were used for comparison of means. Results: African-American and Caucasian men had similar clinical findings based on age, body mass index and prostate specific antigen. There were no statistically significant differences between the dominant tumor nodule volume and total tumor volume (mean 0.712 vs 0.665 cm3, p=0.695) between African-American and Caucasian men. Prostates were heavier in African-American men (mean 55.4 vs 46.3 gm, p <0.03). Despite the significantly greater weight of benign prostate tissue contributing to prostate specific antigen in African-American men, prostate specific antigen mass was not different from that of Caucasian men (mean 0.55 vs 0.558 μg, p=0.95). Prostate specific antigen density was significantly less in African-American men due to larger prostates (mean 0.09 vs 0.105, p <0.02). Conclusions: African-American men with Gleason score 3+3=6 prostate cancer produce less prostate specific antigen than Caucasian men. African-American and Caucasian men had equal serum prostate specific antigen and prostate specific antigen mass despite significantly larger prostates in African-American men with all other parameters, particularly total tumor volume, being the same. This finding has practical implications in T1c cases diagnosed with prostate cancer due to prostate specific antigen screening. Lowering the prostate specific antigen density threshold in African-American men may account for this disparity, particularly in selecting patients for active surveillance programs. References 1 : Early detection of prostate cancer: AUA guideline. J Urol2013; 190: 419. 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Google Scholar © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byMeunier M, Eyraud R, Sénéchal C, Gourtaud G, Roux V, Lanchon C, Brureau L and Blanchet P (2016) Active Surveillance for Favorable Risk Prostate Cancer in African Caribbean Men: Results of a Prospective StudyJournal of Urology, VOL. 197, NO. 5, (1229-1236), Online publication date: 1-May-2017.Kryvenko O, Epstein J and Cote R (2016) Do Black NonHispanic Men Produce Less Prostate Specific Antigen in Benign Prostate Tissue or Cancer Compared to White NonHispanic Men with Gleason Score 6 (Grade Group 1) Prostate Cancer?Journal of Urology, VOL. 196, NO. 6, (1659-1663), Online publication date: 1-Dec-2016. Volume 195Issue 2February 2016Page: 301-306Supplementary Materials Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.Keywordsneoplasm gradingprostate-specific antigenprostatic neoplasmsAfrican AmericansEuropean continental ancestry groupMetricsAuthor Information Oleksandr N. Kryvenko Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Raymond Balise Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Department of Biostatistics, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Nachiketh Soodana Prakash Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Jonathan I. Epstein Departments of Pathology, Urology and Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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