FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857061736> ?p ?o ?g. }

• W1857061736 endingPage "986" @default.
• W1857061736 startingPage "977" @default.
• W1857061736 abstract "We investigated connexin 32 (Cx32)‐deficient mice, a model for the X‐linked form of Charcot‐Marie‐Tooth neuropathy (CMT1X), regarding the impact of low‐grade inflammation on Schwann cell phenotype. Whereas we previously identified macrophages as amplifiers of the neuropathy, we now explicitly focus on the impact of the phagocytes on Schwann cell dedifferentiation, a so far not‐yet addressed disease‐related mechanism for CMT1X. Using mice heterozygously deficient for Cx32 and displaying both Cx32‐positive and ‐negative Schwann cells in one and the same nerve, we could demonstrate that macrophage clusters rather than single macrophages precisely associate with mutant but not with Cx32‐positive Schwann cells. Similarly, in an advanced stage of Schwann cell perturbation, macrophage clusters were strongly associated with NCAM‐ and L1‐positive, dedifferentiated Schwann cells. To clarify the role of macrophages regarding Schwann cell dedifferentiation, we generated Cx32‐deficient mice additionally deficient for the macrophage‐directed cytokine colony‐stimulating factor (CSF)−1. In the absence of CSF‐1, Cx32‐deficient Schwann cells not only showed the expected amelioration in myelin preservation but also failed to upregulate the Schwann cell dedifferentiation markers NCAM and L1. Another novel and unexpected finding in the double mutants was the retained activation of ERK signaling, a pathway which is detrimental for Schwann cell homeostasis in myelin mutant models. Our findings demonstrate that increased ERK signaling can be compatible with the maintenance of Schwann cell differentiation and homeostasis in vivo and identifies CSF‐1‐activated macrophages as crucial mediators of detrimental Schwann cell dedifferentiation in Cx32‐deficient mice. GLIA 2015;63:977–986" @default.
• W1857061736 created "2016-06-24" @default.
• W1857061736 creator A5018543083 @default.
• W1857061736 creator A5038541224 @default.
• W1857061736 creator A5046874780 @default.
• W1857061736 creator A5058152094 @default.
• W1857061736 creator A5071341562 @default.
• W1857061736 creator A5081551414 @default.
• W1857061736 date "2015-01-27" @default.
• W1857061736 modified "2023-10-17" @default.
• W1857061736 title "CSF-1-activated macrophages are target-directed and essential mediators of schwann cell dedifferentiation and dysfunction in Cx32-deficient mice" @default.
• W1857061736 cites W119704665 @default.
• W1857061736 cites W1729621315 @default.
• W1857061736 cites W1913623254 @default.
• W1857061736 cites W1973009368 @default.
• W1857061736 cites W1985611350 @default.
• W1857061736 cites W1989023345 @default.
• W1857061736 cites W1995717532 @default.
• W1857061736 cites W2014105239 @default.
• W1857061736 cites W2014677234 @default.
• W1857061736 cites W2018587983 @default.
• W1857061736 cites W2038781914 @default.
• W1857061736 cites W2040213377 @default.
• W1857061736 cites W2041138285 @default.
• W1857061736 cites W2047515692 @default.
• W1857061736 cites W2047669413 @default.
• W1857061736 cites W2048745419 @default.
• W1857061736 cites W2050272130 @default.
• W1857061736 cites W2058648826 @default.
• W1857061736 cites W2062350971 @default.
• W1857061736 cites W2063680739 @default.
• W1857061736 cites W2065210647 @default.
• W1857061736 cites W2078643379 @default.
• W1857061736 cites W2079782815 @default.
• W1857061736 cites W2088437493 @default.
• W1857061736 cites W2092742155 @default.
• W1857061736 cites W2110234511 @default.
• W1857061736 cites W2113943176 @default.
• W1857061736 cites W2114285561 @default.
• W1857061736 cites W2117075932 @default.
• W1857061736 cites W2131191664 @default.
• W1857061736 cites W2135007468 @default.
• W1857061736 cites W2170578829 @default.
• W1857061736 cites W4211107382 @default.
• W1857061736 doi "https://doi.org/10.1002/glia.22796" @default.
• W1857061736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25628221" @default.
• W1857061736 hasPublicationYear "2015" @default.
• W1857061736 type Work @default.
• W1857061736 sameAs 1857061736 @default.
• W1857061736 citedByCount "47" @default.
• W1857061736 countsByYear W18570617362015 @default.
• W1857061736 countsByYear W18570617362016 @default.
• W1857061736 countsByYear W18570617362017 @default.
• W1857061736 countsByYear W18570617362018 @default.
• W1857061736 countsByYear W18570617362019 @default.
• W1857061736 countsByYear W18570617362020 @default.
• W1857061736 countsByYear W18570617362021 @default.
• W1857061736 countsByYear W18570617362022 @default.
• W1857061736 countsByYear W18570617362023 @default.
• W1857061736 crossrefType "journal-article" @default.
• W1857061736 hasAuthorship W1857061736A5018543083 @default.
• W1857061736 hasAuthorship W1857061736A5038541224 @default.
• W1857061736 hasAuthorship W1857061736A5046874780 @default.
• W1857061736 hasAuthorship W1857061736A5058152094 @default.
• W1857061736 hasAuthorship W1857061736A5071341562 @default.
• W1857061736 hasAuthorship W1857061736A5081551414 @default.
• W1857061736 hasConcept C158157758 @default.
• W1857061736 hasConcept C169760540 @default.
• W1857061736 hasConcept C202751555 @default.
• W1857061736 hasConcept C203014093 @default.
• W1857061736 hasConcept C2777004073 @default.
• W1857061736 hasConcept C2778609137 @default.
• W1857061736 hasConcept C2779244956 @default.
• W1857061736 hasConcept C2780228694 @default.
• W1857061736 hasConcept C2780884517 @default.
• W1857061736 hasConcept C2910362683 @default.
• W1857061736 hasConcept C529278444 @default.
• W1857061736 hasConcept C54355233 @default.
• W1857061736 hasConcept C79879829 @default.
• W1857061736 hasConcept C86803240 @default.
• W1857061736 hasConcept C95444343 @default.
• W1857061736 hasConceptScore W1857061736C158157758 @default.
• W1857061736 hasConceptScore W1857061736C169760540 @default.
• W1857061736 hasConceptScore W1857061736C202751555 @default.
• W1857061736 hasConceptScore W1857061736C203014093 @default.
• W1857061736 hasConceptScore W1857061736C2777004073 @default.
• W1857061736 hasConceptScore W1857061736C2778609137 @default.
• W1857061736 hasConceptScore W1857061736C2779244956 @default.
• W1857061736 hasConceptScore W1857061736C2780228694 @default.
• W1857061736 hasConceptScore W1857061736C2780884517 @default.
• W1857061736 hasConceptScore W1857061736C2910362683 @default.
• W1857061736 hasConceptScore W1857061736C529278444 @default.
• W1857061736 hasConceptScore W1857061736C54355233 @default.
• W1857061736 hasConceptScore W1857061736C79879829 @default.
• W1857061736 hasConceptScore W1857061736C86803240 @default.
• W1857061736 hasConceptScore W1857061736C95444343 @default.
• W1857061736 hasFunder F4320320879 @default.
• W1857061736 hasIssue "6" @default.

• next