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- W1857152978 abstract "Since the emergence of the AIDS epidemic, various associated skin lesions have been recognized. One interesting phenomenon is chronic photosensitivity dermatitis. We report the case of a 44-year old homeless male with a 14-year history of HIV and a CD4 count of 350. He presented to us with a 5-month history of a pruritic photodistributed eruption. Physical examination revealed that he had erythematous, scaly, lichenified, and crusted plaques involving the face, neck, upper chest, and extensor extremities. Sparing of the areas under his watch and bracelet was found. A skin biopsy specimen showed psoriasiform dermatitis with an overlying thick, impetiginized, and hemorrhagic crust. There was prominent single cell necrosis throughout all epidermal layers. A lichenoid dermal infiltrate consisted mainly of lymphocytes and eosinophils. The patient’s presentation was consistent with a photosensitive psoriasiform interface dermatitis. The pathogenesis of this photodermatitis is unclear. Proposed mechanisms include the formation of a neoantigen due to UV exposure, depressed levels of endogenous scavengers leading to increased oxidative stress, and the onset of a pellagra-like dermatosis due to niacin-tryptophan deficiency. It is likely that several of these processes are acting in concert to cause this photoeruption." @default.
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- W1857152978 date "2008-06-28" @default.
- W1857152978 modified "2023-10-14" @default.
- W1857152978 title "Photosensitivity in an HIV-Infected Man" @default.
- W1857152978 doi "https://doi.org/10.1111/j.0303-6987.2005.320ek.x" @default.
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