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• W1857166077 abstract "DiGIR2 is the group I splicing‐ribozyme of the mobile twin‐ribozyme intron Dir.S956‐1, present in Didymium nuclear ribosomal DNA. DiGIR2 is responsible for intron excision, exon ligation, 3′‐splice site hydrolysis, and full‐length intron RNA circle formation. We recently reported that DiGIR2 splicing (intron excision and exon ligation) competes with hydrolysis and subsequent full‐length intron circularization. Here we present experimental evidence that hydrolysis at the 3′‐splice site in DiGIR2 is dependent on structural elements within the P9 subdomain not involved in splicing. Whereas the GCGA tetra‐loop in P9b was found to be important in hydrolytic cleavage, probably due to tertiary RNA–RNA interactions, the P9.2 hairpin structure was found to be essential for hydrolysis. The most important positions in P9.2 include three adenosines in the terminal loop (L9.2) and a consensus kink‐turn motif in the proximal stem. We suggest that the L9.2 adenosines and the kink‐motif represent key regulatory elements in the splicing and hydrolytic reaction pathways." @default.
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• W1857166077 date "2004-02-11" @default.
• W1857166077 modified "2023-10-18" @default.
• W1857166077 title "Hydrolytic cleavage by a group I intron ribozyme is dependent on RNA structures not important for splicing" @default.
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• W1857166077 doi "https://doi.org/10.1111/j.1432-1033.2004.04003.x" @default.
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