FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857295270> ?p ?o ?g. }

• W1857295270 endingPage "39" @default.
• W1857295270 startingPage "31" @default.
• W1857295270 abstract "Abstract The expression of the inducible isoform of nitric oxide synthase (NOS2, iNOS) is increased in patients undergoing sepsis as well as in animal models in which septic shock is induced by injection of bacterial lipopolysaccharide (LPS). Transforming growth factor-β1 (TGF-β1) potently suppresses NO production both in vitro and in vivo. After intraperitoneal injection of LPS, mice over-expressing a cDNA coding for active TGF-β1 in the liver (Alb/ TGF-β1) exhibited reduced serum levels of the NO reaction products NO2– + NO3– compared with controls. Paradoxically, while endotoxemic Alb/ TGF-β1 mice expressed much less NOS2 protein in peritoneal exudate cells than did endotoxemic wild-type mice, Alb/TGF-β1 mice expressed more NOS2 mRNA and protein in both liver and kidney. Alb/ TGF-β1 mice treated with LPS had eightfold higher serum tumor necrosis factor α (TNF-α) levels and experienced increased mortality compared with wild-type mice, which was associated with renal insufficiency. These results suggest that renal dysfunction, decreased production of NO, and/or increased production of TNF-α are associated with increased mortality of endotoxemic Alb/TGF-β1 mice." @default.
• W1857295270 created "2016-06-24" @default.
• W1857295270 creator A5020598676 @default.
• W1857295270 creator A5032548497 @default.
• W1857295270 creator A5038800271 @default.
• W1857295270 creator A5044494633 @default.
• W1857295270 creator A5044929543 @default.
• W1857295270 creator A5055488196 @default.
• W1857295270 creator A5066156238 @default.
• W1857295270 creator A5068856541 @default.
• W1857295270 creator A5072384926 @default.
• W1857295270 creator A5073022985 @default.
• W1857295270 creator A5091034692 @default.
• W1857295270 date "1998-01-01" @default.
• W1857295270 modified "2023-09-23" @default.
• W1857295270 title "Increased mortality, blunted production of nitric oxide, and increased production of TNF-α in endotoxemic TGF-β1 transgenic mice" @default.
• W1857295270 doi "https://doi.org/10.1002/jlb.63.1.31" @default.
• W1857295270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9469470" @default.
• W1857295270 hasPublicationYear "1998" @default.
• W1857295270 type Work @default.
• W1857295270 sameAs 1857295270 @default.
• W1857295270 citedByCount "37" @default.
• W1857295270 countsByYear W18572952702012 @default.
• W1857295270 countsByYear W18572952702013 @default.
• W1857295270 countsByYear W18572952702015 @default.
• W1857295270 countsByYear W18572952702020 @default.
• W1857295270 countsByYear W18572952702022 @default.
• W1857295270 crossrefType "journal-article" @default.
• W1857295270 hasAuthorship W1857295270A5020598676 @default.
• W1857295270 hasAuthorship W1857295270A5032548497 @default.
• W1857295270 hasAuthorship W1857295270A5038800271 @default.
• W1857295270 hasAuthorship W1857295270A5044494633 @default.
• W1857295270 hasAuthorship W1857295270A5044929543 @default.
• W1857295270 hasAuthorship W1857295270A5055488196 @default.
• W1857295270 hasAuthorship W1857295270A5066156238 @default.
• W1857295270 hasAuthorship W1857295270A5068856541 @default.
• W1857295270 hasAuthorship W1857295270A5072384926 @default.
• W1857295270 hasAuthorship W1857295270A5073022985 @default.
• W1857295270 hasAuthorship W1857295270A5091034692 @default.
• W1857295270 hasBestOaLocation W18572952701 @default.
• W1857295270 hasConcept C102230213 @default.
• W1857295270 hasConcept C104317684 @default.
• W1857295270 hasConcept C118131993 @default.
• W1857295270 hasConcept C126322002 @default.
• W1857295270 hasConcept C134018914 @default.
• W1857295270 hasConcept C141035611 @default.
• W1857295270 hasConcept C150903083 @default.
• W1857295270 hasConcept C17991360 @default.
• W1857295270 hasConcept C203014093 @default.
• W1857295270 hasConcept C207001950 @default.
• W1857295270 hasConcept C2777622882 @default.
• W1857295270 hasConcept C2777628635 @default.
• W1857295270 hasConcept C2778384902 @default.
• W1857295270 hasConcept C2778690821 @default.
• W1857295270 hasConcept C2778754761 @default.
• W1857295270 hasConcept C2780091579 @default.
• W1857295270 hasConcept C2780159080 @default.
• W1857295270 hasConcept C519581460 @default.
• W1857295270 hasConcept C55493867 @default.
• W1857295270 hasConcept C71924100 @default.
• W1857295270 hasConcept C86803240 @default.
• W1857295270 hasConceptScore W1857295270C102230213 @default.
• W1857295270 hasConceptScore W1857295270C104317684 @default.
• W1857295270 hasConceptScore W1857295270C118131993 @default.
• W1857295270 hasConceptScore W1857295270C126322002 @default.
• W1857295270 hasConceptScore W1857295270C134018914 @default.
• W1857295270 hasConceptScore W1857295270C141035611 @default.
• W1857295270 hasConceptScore W1857295270C150903083 @default.
• W1857295270 hasConceptScore W1857295270C17991360 @default.
• W1857295270 hasConceptScore W1857295270C203014093 @default.
• W1857295270 hasConceptScore W1857295270C207001950 @default.
• W1857295270 hasConceptScore W1857295270C2777622882 @default.
• W1857295270 hasConceptScore W1857295270C2777628635 @default.
• W1857295270 hasConceptScore W1857295270C2778384902 @default.
• W1857295270 hasConceptScore W1857295270C2778690821 @default.
• W1857295270 hasConceptScore W1857295270C2778754761 @default.
• W1857295270 hasConceptScore W1857295270C2780091579 @default.
• W1857295270 hasConceptScore W1857295270C2780159080 @default.
• W1857295270 hasConceptScore W1857295270C519581460 @default.
• W1857295270 hasConceptScore W1857295270C55493867 @default.
• W1857295270 hasConceptScore W1857295270C71924100 @default.
• W1857295270 hasConceptScore W1857295270C86803240 @default.
• W1857295270 hasIssue "1" @default.
• W1857295270 hasLocation W18572952701 @default.
• W1857295270 hasLocation W18572952702 @default.
• W1857295270 hasOpenAccess W1857295270 @default.
• W1857295270 hasPrimaryLocation W18572952701 @default.
• W1857295270 hasRelatedWork W1986555336 @default.
• W1857295270 hasRelatedWork W2021992999 @default.
• W1857295270 hasRelatedWork W2027340202 @default.
• W1857295270 hasRelatedWork W2051267793 @default.
• W1857295270 hasRelatedWork W2127733257 @default.
• W1857295270 hasRelatedWork W2364207096 @default.
• W1857295270 hasRelatedWork W2371860939 @default.
• W1857295270 hasRelatedWork W2403702177 @default.
• W1857295270 hasRelatedWork W2411512892 @default.
• W1857295270 hasRelatedWork W2417055631 @default.
• W1857295270 hasVolume "63" @default.

• next