Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857365503> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1857365503 endingPage "7" @default.
- W1857365503 startingPage "434" @default.
- W1857365503 abstract "The failure of maternal imprinting at the insulin-like growth factor II (Igf-2) locus predisposes individuals to several clinical conditions, including Wilms tumor. Having two functional Igf-2 genes, therefore, is selectively disadvantageous, and the condition is probably maintained in human populations by recurrent mutation. We propose two models that predict the expected frequency of functionally diploid individuals in a large population, in terms of a mutation rate, mu, and the selection coefficient against functionally diploid individuals, s. In the first model a mutant Igf-2 allele that cannot be imprinted arises from the standard, imprintable allele at a rate mu. Our second model hypothesizes a second modifier locus at which a recessive allele arises at rate mu. Mothers who are homozygous for this recessive modifier allele fail to imprint their eggs. Both models predict the expected frequency of affecteds to be 2 mu/s(1 + mu), approximately twice that predicted by the standard one-locus model of a recessive allele in mutation-selection balance. This frequency suggests that < or = 25% of the cases of Wilms tumor are due to the failure to imprint the maternal Igf-2 gene." @default.
- W1857365503 created "2016-06-24" @default.
- W1857365503 creator A5034944482 @default.
- W1857365503 creator A5064084636 @default.
- W1857365503 date "1995-02-01" @default.
- W1857365503 modified "2023-09-23" @default.
- W1857365503 title "Failure of imprinting at Igf-2: two models of mutation-selection balance." @default.
- W1857365503 cites W137072214 @default.
- W1857365503 cites W1886059158 @default.
- W1857365503 cites W1970728386 @default.
- W1857365503 cites W1990508112 @default.
- W1857365503 cites W2040157600 @default.
- W1857365503 cites W2138646693 @default.
- W1857365503 cites W2254718673 @default.
- W1857365503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1801120" @default.
- W1857365503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7847379" @default.
- W1857365503 hasPublicationYear "1995" @default.
- W1857365503 type Work @default.
- W1857365503 sameAs 1857365503 @default.
- W1857365503 citedByCount "2" @default.
- W1857365503 crossrefType "journal-article" @default.
- W1857365503 hasAuthorship W1857365503A5034944482 @default.
- W1857365503 hasAuthorship W1857365503A5064084636 @default.
- W1857365503 hasConcept C104317684 @default.
- W1857365503 hasConcept C143065580 @default.
- W1857365503 hasConcept C150194340 @default.
- W1857365503 hasConcept C180754005 @default.
- W1857365503 hasConcept C190727270 @default.
- W1857365503 hasConcept C201492766 @default.
- W1857365503 hasConcept C2775999222 @default.
- W1857365503 hasConcept C2908647359 @default.
- W1857365503 hasConcept C37463918 @default.
- W1857365503 hasConcept C54355233 @default.
- W1857365503 hasConcept C71924100 @default.
- W1857365503 hasConcept C84597430 @default.
- W1857365503 hasConcept C86803240 @default.
- W1857365503 hasConcept C94715292 @default.
- W1857365503 hasConcept C98638677 @default.
- W1857365503 hasConcept C99454951 @default.
- W1857365503 hasConceptScore W1857365503C104317684 @default.
- W1857365503 hasConceptScore W1857365503C143065580 @default.
- W1857365503 hasConceptScore W1857365503C150194340 @default.
- W1857365503 hasConceptScore W1857365503C180754005 @default.
- W1857365503 hasConceptScore W1857365503C190727270 @default.
- W1857365503 hasConceptScore W1857365503C201492766 @default.
- W1857365503 hasConceptScore W1857365503C2775999222 @default.
- W1857365503 hasConceptScore W1857365503C2908647359 @default.
- W1857365503 hasConceptScore W1857365503C37463918 @default.
- W1857365503 hasConceptScore W1857365503C54355233 @default.
- W1857365503 hasConceptScore W1857365503C71924100 @default.
- W1857365503 hasConceptScore W1857365503C84597430 @default.
- W1857365503 hasConceptScore W1857365503C86803240 @default.
- W1857365503 hasConceptScore W1857365503C94715292 @default.
- W1857365503 hasConceptScore W1857365503C98638677 @default.
- W1857365503 hasConceptScore W1857365503C99454951 @default.
- W1857365503 hasIssue "2" @default.
- W1857365503 hasLocation W18573655031 @default.
- W1857365503 hasOpenAccess W1857365503 @default.
- W1857365503 hasPrimaryLocation W18573655031 @default.
- W1857365503 hasRelatedWork W1857365503 @default.
- W1857365503 hasRelatedWork W1965394388 @default.
- W1857365503 hasRelatedWork W1972858993 @default.
- W1857365503 hasRelatedWork W2010379147 @default.
- W1857365503 hasRelatedWork W2022324823 @default.
- W1857365503 hasRelatedWork W2063544779 @default.
- W1857365503 hasRelatedWork W2077373463 @default.
- W1857365503 hasRelatedWork W2084087573 @default.
- W1857365503 hasRelatedWork W2131681278 @default.
- W1857365503 hasRelatedWork W2136396881 @default.
- W1857365503 hasVolume "56" @default.
- W1857365503 isParatext "false" @default.
- W1857365503 isRetracted "false" @default.
- W1857365503 magId "1857365503" @default.
- W1857365503 workType "article" @default.