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- W1857372604 abstract "The chemotactic factors directing interneuron migration during cerebrocortical development are essentially unknown. Here we identify the CXC chemokine receptor 4 (CXCR4) in interneuron precursors migrating from the basal forebrain to the neocortex and demonstrate that stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for isolated striatal precursors. In addition, we show that CXCR4 is present in early generated Cajal-Retzius cells of the cortical marginal zone. In mice with a null mutation in CXCR4 or SDF-1, interneurons were severely underrepresented in the superficial layers and ectopically placed in the deep layers of the neocortex. In contrast, the submeningeal positioning of Cajal-Retzius cells was unaffected. Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development." @default.
- W1857372604 created "2016-06-24" @default.
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- W1857372604 date "2003-06-15" @default.
- W1857372604 modified "2023-10-12" @default.
- W1857372604 title "CXCR4 Regulates Interneuron Migration in the Developing Neocortex" @default.
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- W1857372604 doi "https://doi.org/10.1523/jneurosci.23-12-05123.2003" @default.
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