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- W1857382462 abstract "Introduction: Beclin 1 plays a crucial role in autophagy via the Beclin 1 interactome, and is involved in various biological processes such as protein sorting, chemokinesis, and cell death. Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.Areas covered: Beclin 1 plays a key biologic function on cell homeostasis and affects tumorigenesis. In this review, detailing up-to-date knowledge on the tumorigenic role of Beclin 1, its implication in breast cancer, and its utility as a breast cancer-specific drug target is discussed.Expert opinion: Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype." @default.
- W1857382462 created "2016-06-24" @default.
- W1857382462 creator A5040856605 @default.
- W1857382462 creator A5048042870 @default.
- W1857382462 creator A5088372074 @default.
- W1857382462 date "2015-09-11" @default.
- W1857382462 modified "2023-10-15" @default.
- W1857382462 title "The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer" @default.
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