FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857401588> ?p ?o ?g. }

• W1857401588 endingPage "26632" @default.
• W1857401588 startingPage "26615" @default.
• W1857401588 abstract "// Lynn Feys 1 , Benedicte Descamps 2 , Christian Vanhove 2 , Anne Vral 3 , Liv Veldeman 4 , Stefan Vermeulen 5 , Carlos De Wagter 4 , Marc Bracke 1 and Olivier De Wever 1 1 Department of Radiation Oncology and Experimental Cancer Research, Laboratory of Experimental Cancer Research, Ghent University, Ghent, Belgium 2 Department of Electronics and Information System, iMinds-IBiTech-MEDISIP, Ghent University, Ghent, Belgium 3 Department of Basic Medical Sciences, Physiology Group, Ghent University, Ghent, Belgium 4 Department of Radiation Oncology and Experimental Cancer Research, Gent University Hospital, Ghent, Belgium 5 Department of Biomedical Science, HoGent, Ghent, Belgium Correspondence to: Olivier De Wever, email: // Keywords : radiotherapy, triple-negative breast cancer, CXCL12, MIF, AMD3100 Received : July 22, 2015 Accepted : August 29, 2015 Published : September 15, 2015 Abstract Radiotherapy is a mainstay in the postoperative treatment of breast cancer as it reduces the risks of local recurrence and mortality after both conservative surgery and mastectomy. Despite recent efforts to decrease irradiation volumes through accelerated partial irradiation techniques, late cardiac and pulmonary toxicity still occurs after breast irradiation. The importance of this pulmonary injury towards lung metastasis is unclear. Preirradiation of lung epithelial cells induces DNA damage, p53 activation and a secretome enriched in the chemokines SDF-1/CXCL12 and MIF. Irradiated lung epithelial cells stimulate adhesion, spreading, growth, and (transendothelial) migration of human MDA-MB-231 and murine 4T1 breast cancer cells. These metastasis-associated cellular activities were largely mimicked by recombinant CXCL12 and MIF. Moreover, an allosteric inhibitor of the CXCR4 receptor prevented the metastasis-associated cellular activities stimulated by the secretome of irradiated lung epithelial cells. Furthermore, partial (10%) irradiation of the right lung significantly stimulated breast cancer lung-specific metastasis in the syngeneic, orthotopic 4T1 breast cancer model. Our results warrant further investigation of the potential pro-metastatic effects of radiation and indicate the need to develop efficient drugs that will be successful in combination with radiotherapy to prevent therapy-induced spread of cancer cells." @default.
• W1857401588 created "2016-06-24" @default.
• W1857401588 creator A5030359311 @default.
• W1857401588 creator A5030639316 @default.
• W1857401588 creator A5034687681 @default.
• W1857401588 creator A5043525626 @default.
• W1857401588 creator A5049169579 @default.
• W1857401588 creator A5060808021 @default.
• W1857401588 creator A5061866349 @default.
• W1857401588 creator A5065445325 @default.
• W1857401588 creator A5084837815 @default.
• W1857401588 date "2015-09-15" @default.
• W1857401588 modified "2023-10-02" @default.
• W1857401588 title "Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling" @default.
• W1857401588 cites W1565278762 @default.
• W1857401588 cites W1964083798 @default.
• W1857401588 cites W1979389824 @default.
• W1857401588 cites W1980873645 @default.
• W1857401588 cites W1981536714 @default.
• W1857401588 cites W1983222150 @default.
• W1857401588 cites W1992682904 @default.
• W1857401588 cites W2001013907 @default.
• W1857401588 cites W2004280628 @default.
• W1857401588 cites W2010593183 @default.
• W1857401588 cites W2012247886 @default.
• W1857401588 cites W2016682611 @default.
• W1857401588 cites W2027185963 @default.
• W1857401588 cites W2028309086 @default.
• W1857401588 cites W2030689322 @default.
• W1857401588 cites W2034017959 @default.
• W1857401588 cites W2035593232 @default.
• W1857401588 cites W2044890358 @default.
• W1857401588 cites W2047220877 @default.
• W1857401588 cites W2051736635 @default.
• W1857401588 cites W2070990188 @default.
• W1857401588 cites W2082808766 @default.
• W1857401588 cites W2087677309 @default.
• W1857401588 cites W2089370460 @default.
• W1857401588 cites W2092180337 @default.
• W1857401588 cites W2093695644 @default.
• W1857401588 cites W2096027508 @default.
• W1857401588 cites W2098415799 @default.
• W1857401588 cites W2099254999 @default.
• W1857401588 cites W2100025800 @default.
• W1857401588 cites W2100720150 @default.
• W1857401588 cites W2102347658 @default.
• W1857401588 cites W2102790879 @default.
• W1857401588 cites W2102944868 @default.
• W1857401588 cites W2113472355 @default.
• W1857401588 cites W2113577242 @default.
• W1857401588 cites W2115691086 @default.
• W1857401588 cites W2116910749 @default.
• W1857401588 cites W2117158095 @default.
• W1857401588 cites W2119294754 @default.
• W1857401588 cites W2125316253 @default.
• W1857401588 cites W2128532174 @default.
• W1857401588 cites W2129825983 @default.
• W1857401588 cites W2132893003 @default.
• W1857401588 cites W2134068241 @default.
• W1857401588 cites W2135202885 @default.
• W1857401588 cites W2135944976 @default.
• W1857401588 cites W2136112002 @default.
• W1857401588 cites W2139090525 @default.
• W1857401588 cites W2142739240 @default.
• W1857401588 cites W2146088970 @default.
• W1857401588 cites W2146875866 @default.
• W1857401588 cites W2151958354 @default.
• W1857401588 cites W2152139525 @default.
• W1857401588 cites W2154375587 @default.
• W1857401588 cites W2156323704 @default.
• W1857401588 cites W2158615473 @default.
• W1857401588 cites W2162307892 @default.
• W1857401588 cites W2171544336 @default.
• W1857401588 doi "https://doi.org/10.18632/oncotarget.5666" @default.
• W1857401588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4694940" @default.
• W1857401588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26396176" @default.
• W1857401588 hasPublicationYear "2015" @default.
• W1857401588 type Work @default.
• W1857401588 sameAs 1857401588 @default.
• W1857401588 citedByCount "36" @default.
• W1857401588 countsByYear W18574015882016 @default.
• W1857401588 countsByYear W18574015882017 @default.
• W1857401588 countsByYear W18574015882018 @default.
• W1857401588 countsByYear W18574015882019 @default.
• W1857401588 countsByYear W18574015882020 @default.
• W1857401588 countsByYear W18574015882021 @default.
• W1857401588 countsByYear W18574015882022 @default.
• W1857401588 countsByYear W18574015882023 @default.
• W1857401588 crossrefType "journal-article" @default.
• W1857401588 hasAuthorship W1857401588A5030359311 @default.
• W1857401588 hasAuthorship W1857401588A5030639316 @default.
• W1857401588 hasAuthorship W1857401588A5034687681 @default.
• W1857401588 hasAuthorship W1857401588A5043525626 @default.
• W1857401588 hasAuthorship W1857401588A5049169579 @default.
• W1857401588 hasAuthorship W1857401588A5060808021 @default.
• W1857401588 hasAuthorship W1857401588A5061866349 @default.
• W1857401588 hasAuthorship W1857401588A5065445325 @default.
• W1857401588 hasAuthorship W1857401588A5084837815 @default.

• next