Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857406006> ?p ?o ?g. }
- W1857406006 endingPage "622" @default.
- W1857406006 startingPage "609" @default.
- W1857406006 abstract "Abstract Little is known about the genes that interact with Ras signaling pathways to regulate morphogenesis. The synthesis of dorsal eggshell structures in Drosophila melanogaster requires multiple rounds of Ras signaling followed by dramatic epithelial sheet movements. We took advantage of this process to identify genes that link patterning and morphogenesis; we screened lethal mutations on the second chromosome for those that could enhance a weak Ras1 eggshell phenotype. Of 1618 lethal P-element mutations tested, 13 showed significant enhancement, resulting in forked and fused dorsal appendages. Our genetic and molecular analyses together with information from the Berkeley Drosophila Genome Project reveal that 11 of these lines carry mutations in previously characterized genes. Three mutations disrupt the known Ras1 cell signaling components Star, Egfr, and Blistered, while one mutation disrupts Sec61β, implicated in ligand secretion. Seven lines represent cell signaling and cytoskeletal components that are new to the Ras1 pathway; these are Chickadee (Profilin), Tec29, Dreadlocks, POSH, Peanut, Smt3, and MESK2, a suppressor of dominant-negative Ksr. A twelfth insertion disrupts two genes, Nrk, a “neurospecific” receptor tyrosine kinase, and Tpp, which encodes a neuropeptidase. These results suggest that Ras1 signaling during oogenesis involves novel components that may be intimately associated with additional signaling processes and with the reorganization of the cytoskeleton. To determine whether these Ras1 Enhancers function upstream or downstream of the Egf receptor, four mutations were tested for their ability to suppress an activated Egfr construct (λtop) expressed in oogenesis exclusively in the follicle cells. Mutations in Star and l(2)43Bb had no significant effect upon the λtop eggshell defect whereas smt3 and dock alleles significantly suppressed the λtop phenotype." @default.
- W1857406006 created "2016-06-24" @default.
- W1857406006 creator A5005343094 @default.
- W1857406006 creator A5020402658 @default.
- W1857406006 creator A5040389409 @default.
- W1857406006 creator A5067588572 @default.
- W1857406006 date "2001-10-01" @default.
- W1857406006 modified "2023-09-23" @default.
- W1857406006 title "<i>Ras1</i> Interacts With Multiple New Signaling and Cytoskeletal Loci in Drosophila Eggshell Patterning and Morphogenesis" @default.
- W1857406006 cites W122846848 @default.
- W1857406006 cites W1641850409 @default.
- W1857406006 cites W1845241435 @default.
- W1857406006 cites W1868935533 @default.
- W1857406006 cites W1881831880 @default.
- W1857406006 cites W1892595506 @default.
- W1857406006 cites W1924043285 @default.
- W1857406006 cites W1951614488 @default.
- W1857406006 cites W1952752962 @default.
- W1857406006 cites W1965785232 @default.
- W1857406006 cites W1966221337 @default.
- W1857406006 cites W1979179301 @default.
- W1857406006 cites W1981177192 @default.
- W1857406006 cites W1981243923 @default.
- W1857406006 cites W1984981442 @default.
- W1857406006 cites W1986947870 @default.
- W1857406006 cites W1987384465 @default.
- W1857406006 cites W1990152822 @default.
- W1857406006 cites W1991758769 @default.
- W1857406006 cites W1992854237 @default.
- W1857406006 cites W1994005271 @default.
- W1857406006 cites W1996068610 @default.
- W1857406006 cites W1997141247 @default.
- W1857406006 cites W1998634150 @default.
- W1857406006 cites W1999728118 @default.
- W1857406006 cites W2003460583 @default.
- W1857406006 cites W2004373779 @default.
- W1857406006 cites W2007187740 @default.
- W1857406006 cites W2017995506 @default.
- W1857406006 cites W2023417672 @default.
- W1857406006 cites W2024475904 @default.
- W1857406006 cites W2024481695 @default.
- W1857406006 cites W2025870139 @default.
- W1857406006 cites W2028645851 @default.
- W1857406006 cites W2029420359 @default.
- W1857406006 cites W2029744627 @default.
- W1857406006 cites W2031483590 @default.
- W1857406006 cites W2031823151 @default.
- W1857406006 cites W2031929692 @default.
- W1857406006 cites W2038560503 @default.
- W1857406006 cites W2041745051 @default.
- W1857406006 cites W2050666392 @default.
- W1857406006 cites W2050771413 @default.
- W1857406006 cites W2057989418 @default.
- W1857406006 cites W2062452071 @default.
- W1857406006 cites W2064729120 @default.
- W1857406006 cites W2072339454 @default.
- W1857406006 cites W2073148985 @default.
- W1857406006 cites W2086200882 @default.
- W1857406006 cites W2086689509 @default.
- W1857406006 cites W2088445084 @default.
- W1857406006 cites W2090790986 @default.
- W1857406006 cites W2090956156 @default.
- W1857406006 cites W2091488974 @default.
- W1857406006 cites W2092340663 @default.
- W1857406006 cites W2096658690 @default.
- W1857406006 cites W2097790679 @default.
- W1857406006 cites W2100256750 @default.
- W1857406006 cites W2104262655 @default.
- W1857406006 cites W2107851545 @default.
- W1857406006 cites W2110126772 @default.
- W1857406006 cites W2110548948 @default.
- W1857406006 cites W2110643873 @default.
- W1857406006 cites W2110710371 @default.
- W1857406006 cites W2113880526 @default.
- W1857406006 cites W2113906536 @default.
- W1857406006 cites W2121582316 @default.
- W1857406006 cites W2129759722 @default.
- W1857406006 cites W2131219323 @default.
- W1857406006 cites W2139663454 @default.
- W1857406006 cites W2140786734 @default.
- W1857406006 cites W2148481391 @default.
- W1857406006 cites W2149059941 @default.
- W1857406006 cites W2149871892 @default.
- W1857406006 cites W2151673074 @default.
- W1857406006 cites W2151977976 @default.
- W1857406006 cites W2158825995 @default.
- W1857406006 cites W2159211726 @default.
- W1857406006 cites W2160265391 @default.
- W1857406006 cites W2161385800 @default.
- W1857406006 cites W2161679878 @default.
- W1857406006 cites W2161814699 @default.
- W1857406006 cites W2164339920 @default.
- W1857406006 cites W2169694008 @default.
- W1857406006 cites W2171483658 @default.
- W1857406006 cites W2171887312 @default.
- W1857406006 cites W2286196660 @default.
- W1857406006 cites W4297673475 @default.
- W1857406006 cites W4321429163 @default.