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- W18574392 abstract "Monoclonal antibodies are increasingly used for treatment of various diseases, mostly cancer therapy and auto-immune diseases. New chimeric, humanized, or fully-human antibodies specific to novel or already validated targets are being developed in many academic labs as well as in commercial entities. A validation of antibodies in preclinical settings is an important component of the road from discovery to clinic. Preparing sufficient amount of high-quality antibodies for preclinical studies is a challenge in some cases. This article summarizes protocols used in research laboratories, and is based on our own experience in the establishment of stable clones of CHO cells to scaling-up of tissue cultures for production of antibodies in bioreactors." @default.
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- W18574392 date "2008-12-10" @default.
- W18574392 modified "2023-09-23" @default.
- W18574392 title "Scaling-Up and Production of Therapeutic Antibodies for Preclinical Studies" @default.
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- W18574392 doi "https://doi.org/10.1007/978-1-59745-554-1_26" @default.
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