FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857642472> ?p ?o ?g. }

• W1857642472 endingPage "409" @default.
• W1857642472 startingPage "399" @default.
• W1857642472 abstract "HuD is a neuronal RNA-binding protein that plays an important role in neuronal differentiation of the nervous system. HuD has been reported to have three RNA recognition motifs (RRMs) and three splice variants (SVs) that differ in their amino acid sequences between RRM2 and RRM3. This study investigates whether these SVs have specific roles in neuronal differentiation. In primary neural epithelial cells under differentiating conditions, HuD splice variant 1 (HuD-sv1), which is a general form, and HuD-sv2 were expressed at all tested times, whereas HuD-sv4 was transiently expressed at the beginning of differentiation, indicating that HuD-sv4 might play a role compared different from that of HuD-sv1. Indeed, HuD-sv4 did not promote neuronal differentiation in epithelial cells, whereas HuD-sv1 did promote neuronal differentiation. HuD-sv4 overexpression showed less neurite-inducing activity than HuD-sv1 in mouse neuroblastoma N1E-115 cells; however, HuD-sv4 showed stronger growth-arresting activity. HuD-sv1 was localized only in the cytoplasm, whereas HuD-sv4 was localized in both the cytoplasm and the nuclei. The Hu protein has been reported to be involved in translation and alternative splicing in the cytoplasm and nuclei, respectively. Consistent with this observation, HuD-sv1 showed translational activity on p21, which plays a role in growth arrest and neuronal differentiation, whereas HuD-sv4 did not. By contrast, HuD-sv4 showed stronger pre-mRNA splicing activity than did HuD-sv1 on Clasp2, which participates in cell division. Therefore, HuD SVs might play a role in controlling the timing of proliferation/differentiation switching by controlling the translation and alternative splicing of target genes. © 2014 Wiley Periodicals, Inc." @default.
• W1857642472 created "2016-06-24" @default.
• W1857642472 creator A5006144232 @default.
• W1857642472 creator A5017451215 @default.
• W1857642472 creator A5019044106 @default.
• W1857642472 creator A5035479034 @default.
• W1857642472 creator A5049280193 @default.
• W1857642472 date "2014-10-21" @default.
• W1857642472 modified "2023-09-27" @default.
• W1857642472 title "Alternative role of HuD splicing variants in neuronal differentiation" @default.
• W1857642472 cites W1528342365 @default.
• W1857642472 cites W1826852120 @default.
• W1857642472 cites W1835972708 @default.
• W1857642472 cites W1971147333 @default.
• W1857642472 cites W1980060880 @default.
• W1857642472 cites W1982369409 @default.
• W1857642472 cites W1988425964 @default.
• W1857642472 cites W2001320847 @default.
• W1857642472 cites W2001952613 @default.
• W1857642472 cites W2005645322 @default.
• W1857642472 cites W2008416692 @default.
• W1857642472 cites W2012630877 @default.
• W1857642472 cites W20208964 @default.
• W1857642472 cites W2031873527 @default.
• W1857642472 cites W2033305072 @default.
• W1857642472 cites W2035869111 @default.
• W1857642472 cites W2039210066 @default.
• W1857642472 cites W2044583310 @default.
• W1857642472 cites W2048162805 @default.
• W1857642472 cites W2049462796 @default.
• W1857642472 cites W2055930249 @default.
• W1857642472 cites W2060708740 @default.
• W1857642472 cites W2063574627 @default.
• W1857642472 cites W2067613861 @default.
• W1857642472 cites W2074347364 @default.
• W1857642472 cites W2074610739 @default.
• W1857642472 cites W2082551528 @default.
• W1857642472 cites W2086474057 @default.
• W1857642472 cites W2090979828 @default.
• W1857642472 cites W2096259566 @default.
• W1857642472 cites W2109102096 @default.
• W1857642472 cites W2110062940 @default.
• W1857642472 cites W2110141158 @default.
• W1857642472 cites W2113031608 @default.
• W1857642472 cites W2124330168 @default.
• W1857642472 cites W2137368340 @default.
• W1857642472 cites W2142664254 @default.
• W1857642472 cites W2155804510 @default.
• W1857642472 cites W2163805309 @default.
• W1857642472 cites W2170375626 @default.
• W1857642472 doi "https://doi.org/10.1002/jnr.23496" @default.
• W1857642472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25332105" @default.
• W1857642472 hasPublicationYear "2014" @default.
• W1857642472 type Work @default.
• W1857642472 sameAs 1857642472 @default.
• W1857642472 citedByCount "18" @default.
• W1857642472 countsByYear W18576424722017 @default.
• W1857642472 countsByYear W18576424722018 @default.
• W1857642472 countsByYear W18576424722019 @default.
• W1857642472 countsByYear W18576424722020 @default.
• W1857642472 countsByYear W18576424722021 @default.
• W1857642472 countsByYear W18576424722022 @default.
• W1857642472 countsByYear W18576424722023 @default.
• W1857642472 crossrefType "journal-article" @default.
• W1857642472 hasAuthorship W1857642472A5006144232 @default.
• W1857642472 hasAuthorship W1857642472A5017451215 @default.
• W1857642472 hasAuthorship W1857642472A5019044106 @default.
• W1857642472 hasAuthorship W1857642472A5035479034 @default.
• W1857642472 hasAuthorship W1857642472A5049280193 @default.
• W1857642472 hasConcept C104317684 @default.
• W1857642472 hasConcept C105580179 @default.
• W1857642472 hasConcept C113246987 @default.
• W1857642472 hasConcept C148738053 @default.
• W1857642472 hasConcept C190062978 @default.
• W1857642472 hasConcept C194583182 @default.
• W1857642472 hasConcept C202751555 @default.
• W1857642472 hasConcept C41282012 @default.
• W1857642472 hasConcept C54355233 @default.
• W1857642472 hasConcept C54458228 @default.
• W1857642472 hasConcept C67705224 @default.
• W1857642472 hasConcept C86803240 @default.
• W1857642472 hasConcept C95444343 @default.
• W1857642472 hasConceptScore W1857642472C104317684 @default.
• W1857642472 hasConceptScore W1857642472C105580179 @default.
• W1857642472 hasConceptScore W1857642472C113246987 @default.
• W1857642472 hasConceptScore W1857642472C148738053 @default.
• W1857642472 hasConceptScore W1857642472C190062978 @default.
• W1857642472 hasConceptScore W1857642472C194583182 @default.
• W1857642472 hasConceptScore W1857642472C202751555 @default.
• W1857642472 hasConceptScore W1857642472C41282012 @default.
• W1857642472 hasConceptScore W1857642472C54355233 @default.
• W1857642472 hasConceptScore W1857642472C54458228 @default.
• W1857642472 hasConceptScore W1857642472C67705224 @default.
• W1857642472 hasConceptScore W1857642472C86803240 @default.
• W1857642472 hasConceptScore W1857642472C95444343 @default.
• W1857642472 hasFunder F4320320912 @default.
• W1857642472 hasIssue "3" @default.
• W1857642472 hasLocation W18576424721 @default.

• next