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- W1857678463 abstract "Amyloidosis is characterized by extracellular deposition of insoluble protein fibrils that stain with Congo red and appear apple green under polarized light. Resistant to proteolytic degradation, amyloid replaces and destroys normal tissue in vital organs such as the heart, kidneys, and gastrointestinal tract and can lead to early and sudden death. Amyloidosis is usually observed in a systemic form, though 10–20% of cases are localized. We report two cases of upper gastrointestinal amyloidosis that were localized. Case #1 An 80-year-old man with multiple medical problems, including recent coronary artery bypass graft, stroke, atrial fibrillation, congestive heart failure, chronic obstructive pulmonary disease, carotid artery stenosis, chronic renal failure, anemia, chronic lymphocytic leukemia, and asymptomatic cholelithiasis, was admitted to a rehabilitation unit after coronary artery bypass graft surgery. His hospital course was complicated by anemia and hemoccult-positive stool. Esophagogastroduodenoscopy (EGD) showed gastritis, and colonoscopy revealed polyps, with biopsies from the colon confirming tubular and tubulovillous adenomas. Biopsies from the stomach revealed vascular amyloid deposition and mild chronic gastritis without activity. A Congo red stain was positive for amyloid in the vascular walls of the stomach but not the colon (Figure 1). Light microscopy using hematoxylin and eosin stain revealed vascular amyloid deposition in the stomach (Figure 2). Urine analysis did not reveal" @default.
- W1857678463 created "2016-06-24" @default.
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- W1857678463 date "2009-08-01" @default.
- W1857678463 modified "2023-09-24" @default.
- W1857678463 title "Two Cases of Gastric and Esophageal Amyloidosis" @default.
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