FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857678831> ?p ?o ?g. }

• W1857678831 endingPage "174" @default.
• W1857678831 startingPage "171" @default.
• W1857678831 abstract "Abstract: For biomonitoring environmental exposure to acrylonitrile (AN), a monoclonal antibody (mAb) A2D1, was developed to recognize specifically the hemoglobin (Hb) adduct, Hb‐AN, but not Hb itself. This appears to be the first example that a small molecule‐like AN may introduce new antigenicity into hemoglobin, which already exhibits multiple antigenic determinants. This report addresses the localization of the newly formed antigenic sites in human Hb‐AN. As antigenic probes, the AN conjugates of 10 amino acids, six dipeptides, and four tripeptides were prepared as monitored by 1 H NMR, and their antigenicity was evaluated by competitive inhibition immunoassay. A Lys‐ ɛ NH‐AN was found essential to inhibiting activity. The potent peptide‐AN inhibitors, containing a sequence of His and Lys, showed IC 50 at the micromolar concentration, thus implicating human Hb α ‐89,90 and Hb β ‐143,144 in the distal heme pocket region as the new antigenic sites." @default.
• W1857678831 created "2016-06-24" @default.
• W1857678831 creator A5013501334 @default.
• W1857678831 creator A5076498328 @default.
• W1857678831 creator A5089293248 @default.
• W1857678831 date "2004-02-01" @default.
• W1857678831 modified "2023-10-16" @default.
• W1857678831 title "Lysine conjugate of acrylonitrile as antigenic sites in hemoglobin adducts" @default.
• W1857678831 cites W1979185363 @default.
• W1857678831 cites W2018883841 @default.
• W1857678831 cites W2022490398 @default.
• W1857678831 cites W2043065063 @default.
• W1857678831 cites W2056318418 @default.
• W1857678831 cites W2059886108 @default.
• W1857678831 cites W2121252674 @default.
• W1857678831 cites W2169751184 @default.
• W1857678831 cites W2294208797 @default.
• W1857678831 cites W2311239730 @default.
• W1857678831 doi "https://doi.org/10.1111/j.1399-3011.2003.00119.x" @default.
• W1857678831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15009539" @default.
• W1857678831 hasPublicationYear "2004" @default.
• W1857678831 type Work @default.
• W1857678831 sameAs 1857678831 @default.
• W1857678831 citedByCount "5" @default.
• W1857678831 countsByYear W18576788312012 @default.
• W1857678831 countsByYear W18576788312016 @default.
• W1857678831 countsByYear W18576788312017 @default.
• W1857678831 crossrefType "journal-article" @default.
• W1857678831 hasAuthorship W1857678831A5013501334 @default.
• W1857678831 hasAuthorship W1857678831A5076498328 @default.
• W1857678831 hasAuthorship W1857678831A5089293248 @default.
• W1857678831 hasConcept C134306372 @default.
• W1857678831 hasConcept C147483822 @default.
• W1857678831 hasConcept C153911025 @default.
• W1857678831 hasConcept C15920480 @default.
• W1857678831 hasConcept C159654299 @default.
• W1857678831 hasConcept C167392928 @default.
• W1857678831 hasConcept C178790620 @default.
• W1857678831 hasConcept C185592680 @default.
• W1857678831 hasConcept C195616568 @default.
• W1857678831 hasConcept C197336794 @default.
• W1857678831 hasConcept C2776016237 @default.
• W1857678831 hasConcept C2778372188 @default.
• W1857678831 hasConcept C2778917026 @default.
• W1857678831 hasConcept C2779026604 @default.
• W1857678831 hasConcept C2779281246 @default.
• W1857678831 hasConcept C2779909307 @default.
• W1857678831 hasConcept C2780420688 @default.
• W1857678831 hasConcept C33923547 @default.
• W1857678831 hasConcept C515207424 @default.
• W1857678831 hasConcept C521977710 @default.
• W1857678831 hasConcept C542903549 @default.
• W1857678831 hasConcept C54355233 @default.
• W1857678831 hasConcept C55493867 @default.
• W1857678831 hasConcept C71240020 @default.
• W1857678831 hasConcept C86803240 @default.
• W1857678831 hasConceptScore W1857678831C134306372 @default.
• W1857678831 hasConceptScore W1857678831C147483822 @default.
• W1857678831 hasConceptScore W1857678831C153911025 @default.
• W1857678831 hasConceptScore W1857678831C15920480 @default.
• W1857678831 hasConceptScore W1857678831C159654299 @default.
• W1857678831 hasConceptScore W1857678831C167392928 @default.
• W1857678831 hasConceptScore W1857678831C178790620 @default.
• W1857678831 hasConceptScore W1857678831C185592680 @default.
• W1857678831 hasConceptScore W1857678831C195616568 @default.
• W1857678831 hasConceptScore W1857678831C197336794 @default.
• W1857678831 hasConceptScore W1857678831C2776016237 @default.
• W1857678831 hasConceptScore W1857678831C2778372188 @default.
• W1857678831 hasConceptScore W1857678831C2778917026 @default.
• W1857678831 hasConceptScore W1857678831C2779026604 @default.
• W1857678831 hasConceptScore W1857678831C2779281246 @default.
• W1857678831 hasConceptScore W1857678831C2779909307 @default.
• W1857678831 hasConceptScore W1857678831C2780420688 @default.
• W1857678831 hasConceptScore W1857678831C33923547 @default.
• W1857678831 hasConceptScore W1857678831C515207424 @default.
• W1857678831 hasConceptScore W1857678831C521977710 @default.
• W1857678831 hasConceptScore W1857678831C542903549 @default.
• W1857678831 hasConceptScore W1857678831C54355233 @default.
• W1857678831 hasConceptScore W1857678831C55493867 @default.
• W1857678831 hasConceptScore W1857678831C71240020 @default.
• W1857678831 hasConceptScore W1857678831C86803240 @default.
• W1857678831 hasIssue "2" @default.
• W1857678831 hasLocation W18576788311 @default.
• W1857678831 hasLocation W18576788312 @default.
• W1857678831 hasOpenAccess W1857678831 @default.
• W1857678831 hasPrimaryLocation W18576788311 @default.
• W1857678831 hasRelatedWork W1970749005 @default.
• W1857678831 hasRelatedWork W2008317712 @default.
• W1857678831 hasRelatedWork W2078475530 @default.
• W1857678831 hasRelatedWork W2388008635 @default.
• W1857678831 hasRelatedWork W2393764744 @default.
• W1857678831 hasRelatedWork W2417982011 @default.
• W1857678831 hasRelatedWork W4313310612 @default.
• W1857678831 hasRelatedWork W4385354531 @default.
• W1857678831 hasRelatedWork W786416207 @default.
• W1857678831 hasRelatedWork W2169909887 @default.
• W1857678831 hasVolume "63" @default.
• W1857678831 isParatext "false" @default.

• next