FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857698276> ?p ?o ?g. }

• W1857698276 endingPage "2063" @default.
• W1857698276 startingPage "2052" @default.
• W1857698276 abstract "Recently, we cloned and began to characterize a new N-methyl-D-aspartate receptor (NMDAR) subunit, NR3A. Here we extend our earlier findings by showing that recombinantly expressed NR3A in COS cells is biochemically associated with both NR1 and NR2 subunits. In the oocyte or HEK 293 cell expression systems, co-injection of NR3A with NR1/NR2 subunits acts in a dominant-interfering manner, resulting in a decrease in NMDAR unitary conductance, decrease in Ca(2+) permeability, decrease in Mg(2+) sensitivity, and slight increase in mean open time compared with NR1/NR2 channels. The smaller unitary conductance channel has also been observed in primary cortical neurons cultured from wild-type rodent on postnatal day 8 (P8) and similarly found to be relatively insensitive to Mg(2+) block. Consistent with these findings, whole cell NMDA-evoked currents are larger in NR3A-deficient mice compared with wild-type mice, and this effect follows a developmental pattern similar to that of NR3A protein expression on Western blots, with peak expression at P8. Finally, a new longer splice variant of NR3A has been cloned and found to be expressed in rodent cortical neurons by single-cell RT-PCR and in situ hybridization." @default.
• W1857698276 created "2016-06-24" @default.
• W1857698276 creator A5005321774 @default.
• W1857698276 creator A5009646368 @default.
• W1857698276 creator A5015850027 @default.
• W1857698276 creator A5017137382 @default.
• W1857698276 creator A5017487974 @default.
• W1857698276 creator A5018467186 @default.
• W1857698276 creator A5025968088 @default.
• W1857698276 creator A5029138795 @default.
• W1857698276 creator A5042081570 @default.
• W1857698276 creator A5044747530 @default.
• W1857698276 creator A5051429040 @default.
• W1857698276 creator A5066753734 @default.
• W1857698276 creator A5087616224 @default.
• W1857698276 date "2002-04-01" @default.
• W1857698276 modified "2023-10-14" @default.
• W1857698276 title "Characterization and Comparison of the NR3A Subunit of the NMDA Receptor in Recombinant Systems and Primary Cortical Neurons" @default.
• W1857698276 cites W1561818412 @default.
• W1857698276 cites W1562596257 @default.
• W1857698276 cites W1608934724 @default.
• W1857698276 cites W1653383134 @default.
• W1857698276 cites W1772604871 @default.
• W1857698276 cites W1915631305 @default.
• W1857698276 cites W1919210158 @default.
• W1857698276 cites W1966673980 @default.
• W1857698276 cites W1969155399 @default.
• W1857698276 cites W1972884505 @default.
• W1857698276 cites W1977394169 @default.
• W1857698276 cites W1978647995 @default.
• W1857698276 cites W1983342728 @default.
• W1857698276 cites W1986130768 @default.
• W1857698276 cites W1991197087 @default.
• W1857698276 cites W1993579204 @default.
• W1857698276 cites W1995432809 @default.
• W1857698276 cites W1997568797 @default.
• W1857698276 cites W1998347917 @default.
• W1857698276 cites W2024945446 @default.
• W1857698276 cites W2041024256 @default.
• W1857698276 cites W2058200799 @default.
• W1857698276 cites W2089131634 @default.
• W1857698276 cites W2091997673 @default.
• W1857698276 cites W2093573816 @default.
• W1857698276 cites W2100824868 @default.
• W1857698276 cites W2105752803 @default.
• W1857698276 cites W2108119444 @default.
• W1857698276 cites W2122010285 @default.
• W1857698276 cites W2134044586 @default.
• W1857698276 cites W2151199745 @default.
• W1857698276 cites W2159864294 @default.
• W1857698276 cites W2495989242 @default.
• W1857698276 doi "https://doi.org/10.1152/jn.00531.2001" @default.
• W1857698276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11929923" @default.
• W1857698276 hasPublicationYear "2002" @default.
• W1857698276 type Work @default.
• W1857698276 sameAs 1857698276 @default.
• W1857698276 citedByCount "181" @default.
• W1857698276 countsByYear W18576982762012 @default.
• W1857698276 countsByYear W18576982762013 @default.
• W1857698276 countsByYear W18576982762014 @default.
• W1857698276 countsByYear W18576982762015 @default.
• W1857698276 countsByYear W18576982762016 @default.
• W1857698276 countsByYear W18576982762017 @default.
• W1857698276 countsByYear W18576982762018 @default.
• W1857698276 countsByYear W18576982762019 @default.
• W1857698276 countsByYear W18576982762020 @default.
• W1857698276 countsByYear W18576982762021 @default.
• W1857698276 countsByYear W18576982762022 @default.
• W1857698276 countsByYear W18576982762023 @default.
• W1857698276 crossrefType "journal-article" @default.
• W1857698276 hasAuthorship W1857698276A5005321774 @default.
• W1857698276 hasAuthorship W1857698276A5009646368 @default.
• W1857698276 hasAuthorship W1857698276A5015850027 @default.
• W1857698276 hasAuthorship W1857698276A5017137382 @default.
• W1857698276 hasAuthorship W1857698276A5017487974 @default.
• W1857698276 hasAuthorship W1857698276A5018467186 @default.
• W1857698276 hasAuthorship W1857698276A5025968088 @default.
• W1857698276 hasAuthorship W1857698276A5029138795 @default.
• W1857698276 hasAuthorship W1857698276A5042081570 @default.
• W1857698276 hasAuthorship W1857698276A5044747530 @default.
• W1857698276 hasAuthorship W1857698276A5051429040 @default.
• W1857698276 hasAuthorship W1857698276A5066753734 @default.
• W1857698276 hasAuthorship W1857698276A5087616224 @default.
• W1857698276 hasConcept C104292427 @default.
• W1857698276 hasConcept C104317684 @default.
• W1857698276 hasConcept C153911025 @default.
• W1857698276 hasConcept C169760540 @default.
• W1857698276 hasConcept C170493617 @default.
• W1857698276 hasConcept C174510640 @default.
• W1857698276 hasConcept C185263204 @default.
• W1857698276 hasConcept C185592680 @default.
• W1857698276 hasConcept C40767141 @default.
• W1857698276 hasConcept C55493867 @default.
• W1857698276 hasConcept C67018056 @default.
• W1857698276 hasConcept C86803240 @default.
• W1857698276 hasConcept C95444343 @default.
• W1857698276 hasConceptScore W1857698276C104292427 @default.
• W1857698276 hasConceptScore W1857698276C104317684 @default.

• next