FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857723745> ?p ?o ?g. }

• W1857723745 endingPage "973" @default.
• W1857723745 startingPage "968" @default.
• W1857723745 abstract "Abstract The proteolytic cleavage of a variety of membrane proteins, including pro-tumor necrosis factor α (pro-TNF-α), is induced by various reagents such as phorbol 12-myristate 13-acetate (PMA). In this study we generated a human macrophage cell line that constitutively produces TNF-α, and examined how the processing and release of TNF-α are regulated. The processing and release of TNF-α were enhanced by PMA through a protein kinase C-dependent pathway. Although only hy-droxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-α, the PMA-induced processing and release of TNF-α were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline, 3,4-dichloroiso-coumarin (3,4-DCI), iodoacetamide, and Nα-p-tosyl-l-phenylalanine chloromethyl ketone (TPCK). Hydroxamate MMP inhibitors and 1,10-phenanthroline inhibited the processing of TNF-α on the cell surface, whereas 3,4-DCI, iodoacetamide, and TPCK inhibited the transport of TNF-α to the cell surface. These results suggest that serine and/or cysteine protease(s) may be involved in PMA-induced processing and/or transport to the cell surface. J. Leukoc. Biol. 66: 968–973; 1999." @default.
• W1857723745 created "2016-06-24" @default.
• W1857723745 creator A5029381244 @default.
• W1857723745 creator A5050629383 @default.
• W1857723745 creator A5055804570 @default.
• W1857723745 date "1999-12-01" @default.
• W1857723745 modified "2023-09-27" @default.
• W1857723745 title "Regulation of the processing and release of tumor necrosis factor α in a human macrophage cell line" @default.
• W1857723745 cites W1540507088 @default.
• W1857723745 cites W1590318354 @default.
• W1857723745 cites W1605158417 @default.
• W1857723745 cites W1803185035 @default.
• W1857723745 cites W1871950693 @default.
• W1857723745 cites W1904797288 @default.
• W1857723745 cites W1973752319 @default.
• W1857723745 cites W1974444312 @default.
• W1857723745 cites W1979390430 @default.
• W1857723745 cites W1998491594 @default.
• W1857723745 cites W2006105157 @default.
• W1857723745 cites W2007887289 @default.
• W1857723745 cites W2028784401 @default.
• W1857723745 cites W2036842448 @default.
• W1857723745 cites W2041233605 @default.
• W1857723745 cites W2047694858 @default.
• W1857723745 cites W2052626837 @default.
• W1857723745 cites W2054881604 @default.
• W1857723745 cites W2057123987 @default.
• W1857723745 cites W2062784484 @default.
• W1857723745 cites W2072011504 @default.
• W1857723745 cites W2074881372 @default.
• W1857723745 cites W2100837269 @default.
• W1857723745 cites W2116838015 @default.
• W1857723745 cites W2161680868 @default.
• W1857723745 cites W2164802863 @default.
• W1857723745 cites W2169884373 @default.
• W1857723745 cites W2186750753 @default.
• W1857723745 cites W2400193161 @default.
• W1857723745 cites W3145981933 @default.
• W1857723745 cites W7667584 @default.
• W1857723745 doi "https://doi.org/10.1002/jlb.66.6.968" @default.
• W1857723745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10614779" @default.
• W1857723745 hasPublicationYear "1999" @default.
• W1857723745 type Work @default.
• W1857723745 sameAs 1857723745 @default.
• W1857723745 citedByCount "10" @default.
• W1857723745 countsByYear W18577237452012 @default.
• W1857723745 countsByYear W18577237452013 @default.
• W1857723745 countsByYear W18577237452020 @default.
• W1857723745 crossrefType "journal-article" @default.
• W1857723745 hasAuthorship W1857723745A5029381244 @default.
• W1857723745 hasAuthorship W1857723745A5050629383 @default.
• W1857723745 hasAuthorship W1857723745A5055804570 @default.
• W1857723745 hasBestOaLocation W18577237451 @default.
• W1857723745 hasConcept C11960822 @default.
• W1857723745 hasConcept C153911025 @default.
• W1857723745 hasConcept C17991360 @default.
• W1857723745 hasConcept C181199279 @default.
• W1857723745 hasConcept C195794163 @default.
• W1857723745 hasConcept C203014093 @default.
• W1857723745 hasConcept C2776515853 @default.
• W1857723745 hasConcept C2779201268 @default.
• W1857723745 hasConcept C2780043322 @default.
• W1857723745 hasConcept C54355233 @default.
• W1857723745 hasConcept C55493867 @default.
• W1857723745 hasConcept C81885089 @default.
• W1857723745 hasConcept C86803240 @default.
• W1857723745 hasConcept C95444343 @default.
• W1857723745 hasConceptScore W1857723745C11960822 @default.
• W1857723745 hasConceptScore W1857723745C153911025 @default.
• W1857723745 hasConceptScore W1857723745C17991360 @default.
• W1857723745 hasConceptScore W1857723745C181199279 @default.
• W1857723745 hasConceptScore W1857723745C195794163 @default.
• W1857723745 hasConceptScore W1857723745C203014093 @default.
• W1857723745 hasConceptScore W1857723745C2776515853 @default.
• W1857723745 hasConceptScore W1857723745C2779201268 @default.
• W1857723745 hasConceptScore W1857723745C2780043322 @default.
• W1857723745 hasConceptScore W1857723745C54355233 @default.
• W1857723745 hasConceptScore W1857723745C55493867 @default.
• W1857723745 hasConceptScore W1857723745C81885089 @default.
• W1857723745 hasConceptScore W1857723745C86803240 @default.
• W1857723745 hasConceptScore W1857723745C95444343 @default.
• W1857723745 hasIssue "6" @default.
• W1857723745 hasLocation W18577237451 @default.
• W1857723745 hasLocation W18577237452 @default.
• W1857723745 hasOpenAccess W1857723745 @default.
• W1857723745 hasPrimaryLocation W18577237451 @default.
• W1857723745 hasRelatedWork W1972736163 @default.
• W1857723745 hasRelatedWork W1983534615 @default.
• W1857723745 hasRelatedWork W1987051719 @default.
• W1857723745 hasRelatedWork W2007135401 @default.
• W1857723745 hasRelatedWork W2020702542 @default.
• W1857723745 hasRelatedWork W2264137331 @default.
• W1857723745 hasRelatedWork W2418382588 @default.
• W1857723745 hasRelatedWork W2534490254 @default.
• W1857723745 hasRelatedWork W2912830956 @default.
• W1857723745 hasRelatedWork W1976007828 @default.
• W1857723745 hasVolume "66" @default.
• W1857723745 isParatext "false" @default.

• next