FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857733547> ?p ?o ?g. }

• W1857733547 abstract "Drosophila melanogaster, the vinegar fly, has been utilised as a genetic amenable model organism for more than 100 years. In recent years, its use in modelling human cancer has been greatly expanding. In this article, an update of the recent advances in Drosophila research towards understanding cancer development is provided. Genetic analysis in Drosophila has provided considerable insight into the mechanisms controlling tissue growth and cell invasion/metastasis during tumourigenesis, as well as the importance of stem cells in tissue regeneration and cancer, and how genes cooperate in tumourigenesis. Several evolutionarily conserved signalling pathways are emerging as playing key roles in many of these processes, including the Jun kinase, Notch, Wnt, Jak/Stat and the Hippo tissue growth control pathway. Drosophila has also been specifically utilised to model certain human cancers, by expression of the human versions of cancer-causing genes, including multiple endocrine neoplasia type 2, glioblastoma and acute myeloid leukaemia. Finally, the use of Drosophila as a vehicle for anticancer drug discovery is beginning to make an important impact in combating human cancer.Key Concepts: Drosophila is a useful system for modelling human cancer due to the high conservation of critical cancer-causing genes between humans and flies.Many signalling pathways contribute to tissue growth; however, the Hippo growth control pathway is emerging as playing a major role.The Jun kinase signalling pathway plays a context-dependent role in invasion/metastasis.Cell polarity and differentiation factors play important roles in controlling the behaviour of stem cells, which can be usurped in cancer.Cell competition mechanisms are important in removing damaged cells, and the perturbation of this control contributes to tumourigenesis.Cancer is a cooperative process and Drosophila research has revealed many cooperating oncogenes and tumour suppressors.Drosophila provides a useful model system to investigate specific human cancers including multiple endocrine neoplasia type 2, glioblastoma and acute myeloid leukaemia.Drosophila can be utilised to screen for anticancer drugs.Keywords:Drosophila;cancer;cell polarity;proliferation;survival;differentiation;invasion/metastasis;cell competition;tumour microenvironment;chemical screening" @default.
• W1857733547 created "2016-06-24" @default.
• W1857733547 creator A5053998048 @default.
• W1857733547 creator A5073043927 @default.
• W1857733547 creator A5074934904 @default.
• W1857733547 date "2013-03-15" @default.
• W1857733547 modified "2023-09-24" @default.
• W1857733547 title "Modelling Cancer inDrosophila: The Next Generation" @default.
• W1857733547 cites W114150102 @default.
• W1857733547 cites W1506505530 @default.
• W1857733547 cites W1533413123 @default.
• W1857733547 cites W1753082642 @default.
• W1857733547 cites W1839893894 @default.
• W1857733547 cites W1905616951 @default.
• W1857733547 cites W1951931393 @default.
• W1857733547 cites W1963875445 @default.
• W1857733547 cites W1963917344 @default.
• W1857733547 cites W1967582843 @default.
• W1857733547 cites W1967903864 @default.
• W1857733547 cites W1969032952 @default.
• W1857733547 cites W1970047485 @default.
• W1857733547 cites W1970052519 @default.
• W1857733547 cites W1971378055 @default.
• W1857733547 cites W1971605415 @default.
• W1857733547 cites W1971862761 @default.
• W1857733547 cites W1972577475 @default.
• W1857733547 cites W1975053800 @default.
• W1857733547 cites W1976878917 @default.
• W1857733547 cites W1979723568 @default.
• W1857733547 cites W1980912059 @default.
• W1857733547 cites W1981238275 @default.
• W1857733547 cites W1985092406 @default.
• W1857733547 cites W1987041209 @default.
• W1857733547 cites W1988734529 @default.
• W1857733547 cites W1990625173 @default.
• W1857733547 cites W1992459758 @default.
• W1857733547 cites W1993790646 @default.
• W1857733547 cites W1996137175 @default.
• W1857733547 cites W2000823353 @default.
• W1857733547 cites W2000926872 @default.
• W1857733547 cites W2001202251 @default.
• W1857733547 cites W2001242494 @default.
• W1857733547 cites W2006555632 @default.
• W1857733547 cites W2007461563 @default.
• W1857733547 cites W2008348839 @default.
• W1857733547 cites W2010054126 @default.
• W1857733547 cites W2011014156 @default.
• W1857733547 cites W2011599536 @default.
• W1857733547 cites W2012163308 @default.
• W1857733547 cites W2012898911 @default.
• W1857733547 cites W2014545259 @default.
• W1857733547 cites W2019339797 @default.
• W1857733547 cites W2022621553 @default.
• W1857733547 cites W2024166544 @default.
• W1857733547 cites W2025854516 @default.
• W1857733547 cites W2026288613 @default.
• W1857733547 cites W2027303130 @default.
• W1857733547 cites W2028133785 @default.
• W1857733547 cites W2032152026 @default.
• W1857733547 cites W2034381362 @default.
• W1857733547 cites W2034751657 @default.
• W1857733547 cites W2037598426 @default.
• W1857733547 cites W2037666638 @default.
• W1857733547 cites W2038256548 @default.
• W1857733547 cites W2039178317 @default.
• W1857733547 cites W2040502391 @default.
• W1857733547 cites W2043302287 @default.
• W1857733547 cites W2044735472 @default.
• W1857733547 cites W2047195990 @default.
• W1857733547 cites W2050096286 @default.
• W1857733547 cites W2055376350 @default.
• W1857733547 cites W2068774293 @default.
• W1857733547 cites W2073644539 @default.
• W1857733547 cites W2074548203 @default.
• W1857733547 cites W2075291089 @default.
• W1857733547 cites W2077457288 @default.
• W1857733547 cites W2080410251 @default.
• W1857733547 cites W2081645924 @default.
• W1857733547 cites W2083823591 @default.
• W1857733547 cites W2084170466 @default.
• W1857733547 cites W2084472730 @default.
• W1857733547 cites W2085000020 @default.
• W1857733547 cites W2086449926 @default.
• W1857733547 cites W2086620281 @default.
• W1857733547 cites W2086829676 @default.
• W1857733547 cites W2091883691 @default.
• W1857733547 cites W2093047582 @default.
• W1857733547 cites W2096900590 @default.
• W1857733547 cites W2097219225 @default.
• W1857733547 cites W2103342156 @default.
• W1857733547 cites W2104800372 @default.
• W1857733547 cites W2108938866 @default.
• W1857733547 cites W2112552173 @default.
• W1857733547 cites W2115078173 @default.
• W1857733547 cites W2117692326 @default.
• W1857733547 cites W2118810801 @default.
• W1857733547 cites W2119184995 @default.
• W1857733547 cites W2119906258 @default.
• W1857733547 cites W2121134652 @default.
• W1857733547 cites W2122113026 @default.

• next