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• W1857745998 endingPage "1664" @default.
• W1857745998 startingPage "1649" @default.
• W1857745998 abstract "The selective delivery of potent pharmacologically active compounds to target tissue or cells by antibody-drug conjugates makes this immuno-conjugate a promising modality for the treatment of cancers. A thorough understanding of the structural integrity of the linker, the payload and the conjugation site during biological exposure is critical throughout the process of novel linker-payload design and optimization of PK profile. This understanding is a key aspect of the effort to maximize efficacy while minimizing toxicity in preclinical testing and to ensure the translation to the clinical setting. The complexity of this bioconjugate modality is a source of significant challenge for analytical interrogation and analysis in vivo. Therefore, we report herein a survey of various types of biotransformation events that have been elucidated in recent years." @default.
• W1857745998 created "2016-06-24" @default.
• W1857745998 creator A5005909750 @default.
• W1857745998 creator A5033922170 @default.
• W1857745998 creator A5087536634 @default.
• W1857745998 date "2015-07-01" @default.
• W1857745998 modified "2023-09-23" @default.
• W1857745998 title "<i>In vivo</i> biotransformations of antibody–drug conjugates" @default.
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• W1857745998 doi "https://doi.org/10.4155/bio.15.84" @default.
• W1857745998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26226313" @default.
• W1857745998 hasPublicationYear "2015" @default.
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