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- W1857877098 startingPage "13" @default.
- W1857877098 abstract "Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and other arrhythmias that can impact on early and long term clinical outcomes and health economics. Many factors such as disease-induced cardiac remodelling, operative trauma, changes in atrial pressure and chemical stimulation and reflex sympathetic/parasympathetic activation have been implicated in the development of POAF. There is mounting evidence to support a major role for inflammation and oxidative stress in the pathogenesis of POAF. Both are consequences of using cardiopulmonary bypass and reperfusion following ischaemic cardioplegic arrest. Subsequently, several anti-inflammatory and antioxidant drugs have been tested in an attempt to reduce the incidence of POAF. However, prevention remains suboptimal and thus far none of the tested drugs has provided sufficient efficacy to be widely introduced in clinical practice. A better understanding of the cellular and molecular mechanisms responsible for the onset and persistence of POAF is needed to develop more effective prediction and interventions." @default.
- W1857877098 created "2016-06-24" @default.
- W1857877098 creator A5019263601 @default.
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- W1857877098 creator A5027016127 @default.
- W1857877098 creator A5054764500 @default.
- W1857877098 creator A5062819756 @default.
- W1857877098 date "2015-10-01" @default.
- W1857877098 modified "2023-10-16" @default.
- W1857877098 title "Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery" @default.
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