FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1857938233> ?p ?o ?g. }

• W1857938233 endingPage "40691" @default.
• W1857938233 startingPage "40680" @default.
• W1857938233 abstract "// Nicola Bortel 1 , Sorin Armeanu-Ebinger 1 , Evi Schmid 1 , Bettina Kirchner 1 , Jan Frank 2 , Alexa Kocher 2 , Christina Schiborr 2 , Steven Warmann 1 , Jörg Fuchs 1 , Verena Ellerkamp 1 1 Department of Pediatric Surgery and Pediatric Urology, University Hospital Tuebingen, D-72076 Tuebingen, Germany 2 Institute of Biological Chemistry and Nutrition, University of Hohenheim, Division of Biofunctionality and Safety of Food, D-70599 Stuttgart, Germany Correspondence to: Verena Ellerkamp, e-mail: mail@verenaellerkamp.de Keywords: curcumin, hepatocellular carcinoma, cisplatin, pediatric, orthotopic tumor model Received: April 17, 2015      Accepted: September 13, 2015      Published: October 19, 2015 ABSTRACT In children with hepatocellular carcinoma (pHCC) the 5-year overall survival rate is poor. Effects of cytostatic therapies such as cisplatin and doxorubicin are limited due to chemoresistance and tumor relapse. In adult HCC, several antitumor properties are described for the use of curcumin. Curcumin is one of the best-investigated phytochemicals in complementary oncology without relevant side effects. Its use is limited by low bioavailability. Little is known about the influence of curcumin on pediatric epithelial hepatic malignancies. We investigated the effects of curcumin in combination with cisplatin on two pediatric epithelial liver tumor cell lines. As mechanisms of action inhibition of NFkappaB, beta-catenin, and decrease of cyclin D were identified. Using a mouse xenograft model we could show a significant decrease of alpha-fetoprotein after combination therapy of oral micellar curcumin and cisplatin. Significant concentrations of curcuminoids were found in blood samples, organ lysates, and tumor tissue after oral micellar curcumin administration. Micellar curcumin in combination with cisplatin can be a promising strategy for treatment of pediatric HCC." @default.
• W1857938233 created "2016-06-24" @default.
• W1857938233 creator A5002321842 @default.
• W1857938233 creator A5004385713 @default.
• W1857938233 creator A5008375272 @default.
• W1857938233 creator A5009286398 @default.
• W1857938233 creator A5016645028 @default.
• W1857938233 creator A5035779817 @default.
• W1857938233 creator A5041538754 @default.
• W1857938233 creator A5049372506 @default.
• W1857938233 creator A5066825921 @default.
• W1857938233 creator A5071961324 @default.
• W1857938233 date "2015-10-19" @default.
• W1857938233 modified "2023-10-02" @default.
• W1857938233 title "Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein<i>in vitro</i>and<i>in vivo</i>involving the NFkappaB- and the beta-catenin pathways" @default.
• W1857938233 cites W1565266604 @default.
• W1857938233 cites W1604068141 @default.
• W1857938233 cites W1700829084 @default.
• W1857938233 cites W1901407464 @default.
• W1857938233 cites W1964423256 @default.
• W1857938233 cites W1966897236 @default.
• W1857938233 cites W1969630613 @default.
• W1857938233 cites W1974901513 @default.
• W1857938233 cites W1975893269 @default.
• W1857938233 cites W1976106807 @default.
• W1857938233 cites W1980455616 @default.
• W1857938233 cites W1980567930 @default.
• W1857938233 cites W1985717888 @default.
• W1857938233 cites W1987329376 @default.
• W1857938233 cites W1990089472 @default.
• W1857938233 cites W1994529592 @default.
• W1857938233 cites W1995645096 @default.
• W1857938233 cites W1995850170 @default.
• W1857938233 cites W2000248590 @default.
• W1857938233 cites W2007299371 @default.
• W1857938233 cites W2009319050 @default.
• W1857938233 cites W2011257176 @default.
• W1857938233 cites W2018336584 @default.
• W1857938233 cites W2019800711 @default.
• W1857938233 cites W2021589569 @default.
• W1857938233 cites W2027320585 @default.
• W1857938233 cites W2028521648 @default.
• W1857938233 cites W2040188940 @default.
• W1857938233 cites W2040350223 @default.
• W1857938233 cites W2042762777 @default.
• W1857938233 cites W2048342998 @default.
• W1857938233 cites W2054603877 @default.
• W1857938233 cites W2058766401 @default.
• W1857938233 cites W2060680825 @default.
• W1857938233 cites W2065612142 @default.
• W1857938233 cites W2068842703 @default.
• W1857938233 cites W2073798776 @default.
• W1857938233 cites W2073918514 @default.
• W1857938233 cites W2105979117 @default.
• W1857938233 cites W2113576996 @default.
• W1857938233 cites W2123284347 @default.
• W1857938233 cites W2125295729 @default.
• W1857938233 cites W2128249174 @default.
• W1857938233 cites W2129131491 @default.
• W1857938233 cites W2135770108 @default.
• W1857938233 cites W2138508372 @default.
• W1857938233 cites W2150155099 @default.
• W1857938233 cites W2151101177 @default.
• W1857938233 cites W2157843415 @default.
• W1857938233 cites W2161756544 @default.
• W1857938233 cites W2164193415 @default.
• W1857938233 cites W2170839518 @default.
• W1857938233 cites W2324360643 @default.
• W1857938233 cites W2335615237 @default.
• W1857938233 cites W42013536 @default.
• W1857938233 cites W74993898 @default.
• W1857938233 doi "https://doi.org/10.18632/oncotarget.5673" @default.
• W1857938233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4747361" @default.
• W1857938233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26515460" @default.
• W1857938233 hasPublicationYear "2015" @default.
• W1857938233 type Work @default.
• W1857938233 sameAs 1857938233 @default.
• W1857938233 citedByCount "29" @default.
• W1857938233 countsByYear W18579382332016 @default.
• W1857938233 countsByYear W18579382332017 @default.
• W1857938233 countsByYear W18579382332018 @default.
• W1857938233 countsByYear W18579382332019 @default.
• W1857938233 countsByYear W18579382332020 @default.
• W1857938233 countsByYear W18579382332021 @default.
• W1857938233 countsByYear W18579382332023 @default.
• W1857938233 crossrefType "journal-article" @default.
• W1857938233 hasAuthorship W1857938233A5002321842 @default.
• W1857938233 hasAuthorship W1857938233A5004385713 @default.
• W1857938233 hasAuthorship W1857938233A5008375272 @default.
• W1857938233 hasAuthorship W1857938233A5009286398 @default.
• W1857938233 hasAuthorship W1857938233A5016645028 @default.
• W1857938233 hasAuthorship W1857938233A5035779817 @default.
• W1857938233 hasAuthorship W1857938233A5041538754 @default.
• W1857938233 hasAuthorship W1857938233A5049372506 @default.
• W1857938233 hasAuthorship W1857938233A5066825921 @default.
• W1857938233 hasAuthorship W1857938233A5071961324 @default.
• W1857938233 hasBestOaLocation W18579382331 @default.
• W1857938233 hasConcept C126322002 @default.

• next