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- W1858025662 abstract "Exoenzyme S from Pseudomonas aeruginosa is a unique T cell mitogen; it is a powerful immunostimulus that activates a large proportion of T cells, but results in delayed and reduced lymphocyte proliferation. This study was performed to explain the discrepancy between early T cell activation and subsequent proliferation. Studies revealed that exoenzyme S induced rapid and unsustained surface expression of CD69, but could not induce interleukin-2 receptor alpha (IL-2R alpha) up-regulation on T cells. IL-2 was undetectable in supernatants and addition of rIL-2 could not reverse the unresponsiveness, indicating that anergy was not involved. Exoenzyme S induced membrane phosphatidylserine translocation, DNA hypodiploidy, and DNA fragmentation, implicating apoptosis as the mechanism for the unresponsiveness. Exoenzyme S-induced apoptosis shows features of both propriocidal and death by neglect, suggesting shared characteristics of an intermediate pathway. Thus, a Pseudomonas exoproduct induces T cell apoptosis, which may contribute to the pathogenesis of Pseudomonas infections in diseases such as cystic fibrosis." @default.
- W1858025662 created "2016-06-24" @default.
- W1858025662 creator A5039796914 @default.
- W1858025662 creator A5073886576 @default.
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- W1858025662 date "2000-06-01" @default.
- W1858025662 modified "2023-10-10" @default.
- W1858025662 title "Exoenzyme S from <i>Pseudomonas aeruginosa</i> induces apoptosis in T lymphocytes" @default.
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- W1858025662 doi "https://doi.org/10.1002/jlb.67.6.808" @default.
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