FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W185803604> ?p ?o ?g. }

• W185803604 endingPage "1083" @default.
• W185803604 startingPage "1075" @default.
• W185803604 abstract "Most organisms have behavioral and physiological circadian rhythms, which are controlled by an endogenous clock. Although genetic analysis has revealed the intracellular mechanism of the circadian clock, the manner in which this clock communicates its temporal information to produce systemic regulation is still largely unknown. Sleep behavior was measured using the Drosophila Activity Monitoring System (DAMS) monitor under a 12 h light:12 h dark cycle and constant darkness (DD), and 5 min without recorded activity were defined as a bout of sleep. Here we show that Drosophila insulin-like peptides (DILPs) and their receptor (DInR) regulate sleep behavior. All mutants of the seven dilps and the mutant of their receptor exhibit decreases of total sleep except dilp4 mutants, whereas upregulation of DILP and DInR in the nervous system led to increased sleep. Histological analysis identified four previously unidentified neurons expressing DILP: D1, P1, L1, and L2, of which L1 and L2 belong to the LNd and LNv clock neurons that separately regulate different times of sleep. In addition, dilp2 levels significantly decrease when flies were fasted, which is consistent with a previous report that starvation inhibits sleep, further indicating that the dilp system is involved in sleep regulation. Taken together, the results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep." @default.
• W185803604 created "2016-06-24" @default.
• W185803604 creator A5005814364 @default.
• W185803604 creator A5018117166 @default.
• W185803604 creator A5049477911 @default.
• W185803604 creator A5052687208 @default.
• W185803604 creator A5077768436 @default.
• W185803604 creator A5089733664 @default.
• W185803604 date "2015-07-01" @default.
• W185803604 modified "2023-10-10" @default.
• W185803604 title "Regulation of Sleep by Insulin-like Peptide System in<i>Drosophila melanogaster</i>" @default.
• W185803604 cites W100338727 @default.
• W185803604 cites W153901436 @default.
• W185803604 cites W1632458568 @default.
• W185803604 cites W1968173546 @default.
• W185803604 cites W1969832012 @default.
• W185803604 cites W1972165232 @default.
• W185803604 cites W1976250891 @default.
• W185803604 cites W1978078486 @default.
• W185803604 cites W1979672662 @default.
• W185803604 cites W1980083315 @default.
• W185803604 cites W1981225280 @default.
• W185803604 cites W1981858629 @default.
• W185803604 cites W1982268494 @default.
• W185803604 cites W1982509827 @default.
• W185803604 cites W1984726207 @default.
• W185803604 cites W1987942547 @default.
• W185803604 cites W1990296960 @default.
• W185803604 cites W1999819966 @default.
• W185803604 cites W2006641069 @default.
• W185803604 cites W2011568655 @default.
• W185803604 cites W2013811704 @default.
• W185803604 cites W2021185182 @default.
• W185803604 cites W2029166453 @default.
• W185803604 cites W2030651245 @default.
• W185803604 cites W2044221124 @default.
• W185803604 cites W2045804978 @default.
• W185803604 cites W2048169326 @default.
• W185803604 cites W2054162066 @default.
• W185803604 cites W2056213320 @default.
• W185803604 cites W2062571806 @default.
• W185803604 cites W2064490629 @default.
• W185803604 cites W2073318890 @default.
• W185803604 cites W2075668179 @default.
• W185803604 cites W2081610458 @default.
• W185803604 cites W2083850113 @default.
• W185803604 cites W2123607010 @default.
• W185803604 cites W2124409628 @default.
• W185803604 cites W2126761533 @default.
• W185803604 cites W2127108219 @default.
• W185803604 cites W2132331751 @default.
• W185803604 cites W2132350109 @default.
• W185803604 cites W2141369667 @default.
• W185803604 cites W2157725915 @default.
• W185803604 doi "https://doi.org/10.5665/sleep.4816" @default.
• W185803604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4481013" @default.
• W185803604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25581915" @default.
• W185803604 hasPublicationYear "2015" @default.
• W185803604 type Work @default.
• W185803604 sameAs 185803604 @default.
• W185803604 citedByCount "63" @default.
• W185803604 countsByYear W1858036042015 @default.
• W185803604 countsByYear W1858036042016 @default.
• W185803604 countsByYear W1858036042017 @default.
• W185803604 countsByYear W1858036042018 @default.
• W185803604 countsByYear W1858036042019 @default.
• W185803604 countsByYear W1858036042020 @default.
• W185803604 countsByYear W1858036042021 @default.
• W185803604 countsByYear W1858036042022 @default.
• W185803604 countsByYear W1858036042023 @default.
• W185803604 crossrefType "journal-article" @default.
• W185803604 hasAuthorship W185803604A5005814364 @default.
• W185803604 hasAuthorship W185803604A5018117166 @default.
• W185803604 hasAuthorship W185803604A5049477911 @default.
• W185803604 hasAuthorship W185803604A5052687208 @default.
• W185803604 hasAuthorship W185803604A5077768436 @default.
• W185803604 hasAuthorship W185803604A5089733664 @default.
• W185803604 hasBestOaLocation W1858036041 @default.
• W185803604 hasConcept C104317684 @default.
• W185803604 hasConcept C111919701 @default.
• W185803604 hasConcept C121446783 @default.
• W185803604 hasConcept C126322002 @default.
• W185803604 hasConcept C127561419 @default.
• W185803604 hasConcept C134018914 @default.
• W185803604 hasConcept C143065580 @default.
• W185803604 hasConcept C169760540 @default.
• W185803604 hasConcept C184738001 @default.
• W185803604 hasConcept C2775841894 @default.
• W185803604 hasConcept C2780104201 @default.
• W185803604 hasConcept C38606739 @default.
• W185803604 hasConcept C41008148 @default.
• W185803604 hasConcept C54355233 @default.
• W185803604 hasConcept C71924100 @default.
• W185803604 hasConcept C86803240 @default.
• W185803604 hasConcept C95444343 @default.
• W185803604 hasConceptScore W185803604C104317684 @default.
• W185803604 hasConceptScore W185803604C111919701 @default.
• W185803604 hasConceptScore W185803604C121446783 @default.

• next