Matches in SemOpenAlex for { <https://semopenalex.org/work/W1858051302> ?p ?o ?g. }
- W1858051302 endingPage "6266" @default.
- W1858051302 startingPage "6252" @default.
- W1858051302 abstract "Velcade is one of the inescapable drug to treat patient suffering from multiple myeloma (MM) and resistance to this drug represents a major drawback for patients. However, the mechanisms underlying velcade resistance remain incompletely understood. We derived several U266 MM cell clones that resist to velcade. U266-resistant cells were resistant to velcade-induced cell death but exhibited a similar sensitivity to various proapoptotic stimuli. Careful analysis of proteosomal subunits and proteasome enzymatic activities showed that neither the composition nor the activity of the proteasome was affected in velcade-resistant cells. Elimination of velcade-induced poly-ubiquitinated proteins and protein aggregates was drastically stimulated in the resistant cells and correlated with increased cell survival. Inhibition of the lysosomal activity in velcade-resistant cells resulted in an increase of cell aggregates and decrease survival, indicating that aggregates are eliminated through lysosomal degradation. In addition, pangenomic profiling of velcade-sensitive and resistant cells showed that the small heat shock protein HSPB8 was overexpressed in resistant cells. Finally, gain and loss of function experiment demonstrated that HSPB8 is a key factor for velcade resistance. In conclusion, HSPB8 plays an important role for the elimination of aggregates in velcade-resistant cells that contributes to their enhanced survival." @default.
- W1858051302 created "2016-06-24" @default.
- W1858051302 creator A5007084558 @default.
- W1858051302 creator A5019765162 @default.
- W1858051302 creator A5030082681 @default.
- W1858051302 creator A5034528977 @default.
- W1858051302 creator A5038903944 @default.
- W1858051302 creator A5039959145 @default.
- W1858051302 creator A5051365781 @default.
- W1858051302 creator A5068311974 @default.
- W1858051302 creator A5074620596 @default.
- W1858051302 date "2014-07-09" @default.
- W1858051302 modified "2023-10-18" @default.
- W1858051302 title "The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells" @default.
- W1858051302 cites W119139793 @default.
- W1858051302 cites W1485176492 @default.
- W1858051302 cites W1949358987 @default.
- W1858051302 cites W1976489571 @default.
- W1858051302 cites W1984678830 @default.
- W1858051302 cites W1984998337 @default.
- W1858051302 cites W2010163650 @default.
- W1858051302 cites W2017937681 @default.
- W1858051302 cites W2019313913 @default.
- W1858051302 cites W2023215532 @default.
- W1858051302 cites W2024267837 @default.
- W1858051302 cites W2024336151 @default.
- W1858051302 cites W2039180923 @default.
- W1858051302 cites W2045257543 @default.
- W1858051302 cites W2047717393 @default.
- W1858051302 cites W2052169053 @default.
- W1858051302 cites W2057997371 @default.
- W1858051302 cites W2060909830 @default.
- W1858051302 cites W2063436192 @default.
- W1858051302 cites W2066699439 @default.
- W1858051302 cites W2067149213 @default.
- W1858051302 cites W2072714194 @default.
- W1858051302 cites W2085431272 @default.
- W1858051302 cites W2096207943 @default.
- W1858051302 cites W2096966529 @default.
- W1858051302 cites W2098654505 @default.
- W1858051302 cites W2101035019 @default.
- W1858051302 cites W2108075231 @default.
- W1858051302 cites W2108235071 @default.
- W1858051302 cites W2112286580 @default.
- W1858051302 cites W2116511323 @default.
- W1858051302 cites W2116896548 @default.
- W1858051302 cites W2122597368 @default.
- W1858051302 cites W2124560610 @default.
- W1858051302 cites W2129913554 @default.
- W1858051302 cites W2134334757 @default.
- W1858051302 cites W2146502962 @default.
- W1858051302 cites W2150123812 @default.
- W1858051302 cites W2164669124 @default.
- W1858051302 cites W2166987747 @default.
- W1858051302 cites W2167188607 @default.
- W1858051302 cites W2169249834 @default.
- W1858051302 cites W4236730981 @default.
- W1858051302 cites W4252175385 @default.
- W1858051302 cites W4376542883 @default.
- W1858051302 doi "https://doi.org/10.18632/oncotarget.2193" @default.
- W1858051302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4171627" @default.
- W1858051302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25051369" @default.
- W1858051302 hasPublicationYear "2014" @default.
- W1858051302 type Work @default.
- W1858051302 sameAs 1858051302 @default.
- W1858051302 citedByCount "41" @default.
- W1858051302 countsByYear W18580513022014 @default.
- W1858051302 countsByYear W18580513022015 @default.
- W1858051302 countsByYear W18580513022016 @default.
- W1858051302 countsByYear W18580513022017 @default.
- W1858051302 countsByYear W18580513022018 @default.
- W1858051302 countsByYear W18580513022019 @default.
- W1858051302 countsByYear W18580513022020 @default.
- W1858051302 countsByYear W18580513022021 @default.
- W1858051302 countsByYear W18580513022022 @default.
- W1858051302 countsByYear W18580513022023 @default.
- W1858051302 crossrefType "journal-article" @default.
- W1858051302 hasAuthorship W1858051302A5007084558 @default.
- W1858051302 hasAuthorship W1858051302A5019765162 @default.
- W1858051302 hasAuthorship W1858051302A5030082681 @default.
- W1858051302 hasAuthorship W1858051302A5034528977 @default.
- W1858051302 hasAuthorship W1858051302A5038903944 @default.
- W1858051302 hasAuthorship W1858051302A5039959145 @default.
- W1858051302 hasAuthorship W1858051302A5051365781 @default.
- W1858051302 hasAuthorship W1858051302A5068311974 @default.
- W1858051302 hasAuthorship W1858051302A5074620596 @default.
- W1858051302 hasBestOaLocation W18580513021 @default.
- W1858051302 hasConcept C104317684 @default.
- W1858051302 hasConcept C114851261 @default.
- W1858051302 hasConcept C185592680 @default.
- W1858051302 hasConcept C190283241 @default.
- W1858051302 hasConcept C203014093 @default.
- W1858051302 hasConcept C203522944 @default.
- W1858051302 hasConcept C205260736 @default.
- W1858051302 hasConcept C25602115 @default.
- W1858051302 hasConcept C27740335 @default.
- W1858051302 hasConcept C2776364478 @default.
- W1858051302 hasConcept C2777478702 @default.