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- W185807547 abstract "Dopamine (DA)-derived TIQs (Condensation pdts.) occur in animals from acetaldehyde during ethanol oxidation, but formation in human alcoholics has not been shown. Using HPLC and GC, we now have evidence for significant excretion of DA-derived TIQs by alcoholics during detox. The role of TIQs in alcoholism is unclear, but in animals the TIQs promote ethanol consumption, alter withdrawal, release amines, inhibit enzymes, and induce neuronal degeneration. One working hypothesis in our lab is that certain TIQ metabolites underlie alcoholic brain damage." @default.
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- W185807547 date "1979-01-01" @default.
- W185807547 modified "2023-09-26" @default.
- W185807547 title "DOPAMINE-RELATED TETRAHYDROISOQUINOLINE (TIQ) EXCRETION BY ALCOHOLICS" @default.
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- W185807547 doi "https://doi.org/10.1016/b978-1-4832-8363-0.50295-0" @default.
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