FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1858247923> ?p ?o ?g. }

• W1858247923 abstract "Several mechanisms are involved in controlling intracellular survival of pathogenic mycobacteria in host macrophages, but how these mechanisms are regulated remains poorly understood. We report a role for Kelch-like ECH-associated protein 1 (Keap1), an oxidative stress sensor, in regulating inflammation induced by infection with Mycobacterium avium in human primary macrophages. By using confocal microscopy, we found that Keap1 associated with mycobacterial phagosomes in a time-dependent manner, whereas siRNA-mediated knockdown of Keap1 increased M. avium-induced expression of inflammatory cytokines and type I interferons (IFNs). We show evidence of a mechanism whereby Keap1, as part of an E3 ubiquitin ligase complex with Cul3 and Rbx1, facilitates ubiquitination and degradation of IκB kinase (IKK)-β thus terminating IKK activity. Keap1 knockdown led to increased nuclear translocation of transcription factors NF-κB, IFN regulatory factor (IRF) 1, and IRF5 driving the expression of inflammatory cytokines and IFN-β. Furthermore, knockdown of other members of the Cul3 ubiquitin ligase complex also led to increased cytokine expression, further implicating this ligase complex in the regulation of the IKK family. Finally, increased inflammatory responses in Keap1-silenced cells contributed to decreased intracellular growth of M. avium in primary human macrophages that was reconstituted with inhibitors of IKKβ or TANK-binding kinase 1 (TBK1). Taken together, we propose that Keap1 acts as a negative regulator for the control of inflammatory signaling in M. avium-infected human primary macrophages. Although this might be important to avoid sustained or overwhelming inflammation, our data suggest that a negative consequence could be facilitated growth of pathogens like M. avium inside macrophages." @default.
• W1858247923 created "2016-06-24" @default.
• W1858247923 creator A5011458022 @default.
• W1858247923 creator A5018332396 @default.
• W1858247923 creator A5030940837 @default.
• W1858247923 creator A5031856620 @default.
• W1858247923 creator A5040915656 @default.
• W1858247923 creator A5053779035 @default.
• W1858247923 creator A5054748771 @default.
• W1858247923 creator A5070564455 @default.
• W1858247923 creator A5083374667 @default.
• W1858247923 creator A5089911913 @default.
• W1858247923 creator A5027750651 @default.
• W1858247923 date "2015-07-20" @default.
• W1858247923 modified "2023-09-26" @default.
• W1858247923 title "Keap1 regulates inflammatory signaling in <i>Mycobacterium avium</i> -infected human macrophages" @default.
• W1858247923 cites W1523693806 @default.
• W1858247923 cites W1531083859 @default.
• W1858247923 cites W1537388372 @default.
• W1858247923 cites W1649095302 @default.
• W1858247923 cites W1785455093 @default.
• W1858247923 cites W1972269365 @default.
• W1858247923 cites W1973720948 @default.
• W1858247923 cites W1979153645 @default.
• W1858247923 cites W1979921127 @default.
• W1858247923 cites W1980094540 @default.
• W1858247923 cites W1984355221 @default.
• W1858247923 cites W1995445783 @default.
• W1858247923 cites W2007090411 @default.
• W1858247923 cites W2008969317 @default.
• W1858247923 cites W2011678998 @default.
• W1858247923 cites W2012167979 @default.
• W1858247923 cites W2014918593 @default.
• W1858247923 cites W2015715260 @default.
• W1858247923 cites W2023598683 @default.
• W1858247923 cites W2042436346 @default.
• W1858247923 cites W2042751933 @default.
• W1858247923 cites W2056230207 @default.
• W1858247923 cites W2056521763 @default.
• W1858247923 cites W2056808649 @default.
• W1858247923 cites W2059572643 @default.
• W1858247923 cites W2061098514 @default.
• W1858247923 cites W2062025882 @default.
• W1858247923 cites W2063548806 @default.
• W1858247923 cites W2065217848 @default.
• W1858247923 cites W2067555798 @default.
• W1858247923 cites W2084224574 @default.
• W1858247923 cites W2087187487 @default.
• W1858247923 cites W2089813815 @default.
• W1858247923 cites W2091129202 @default.
• W1858247923 cites W2095415269 @default.
• W1858247923 cites W2098257571 @default.
• W1858247923 cites W2101540252 @default.
• W1858247923 cites W2102354517 @default.
• W1858247923 cites W2102603631 @default.
• W1858247923 cites W2106195012 @default.
• W1858247923 cites W2118194631 @default.
• W1858247923 cites W2119579802 @default.
• W1858247923 cites W2129443010 @default.
• W1858247923 cites W2130846764 @default.
• W1858247923 cites W2132490889 @default.
• W1858247923 cites W2132822330 @default.
• W1858247923 cites W2143516276 @default.
• W1858247923 cites W2156171182 @default.
• W1858247923 cites W2158342892 @default.
• W1858247923 cites W2158969445 @default.
• W1858247923 cites W2160411684 @default.
• W1858247923 cites W2312445525 @default.
• W1858247923 cites W2743254891 @default.
• W1858247923 doi "https://doi.org/10.1073/pnas.1423449112" @default.
• W1858247923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4534286" @default.
• W1858247923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26195781" @default.
• W1858247923 hasPublicationYear "2015" @default.
• W1858247923 type Work @default.
• W1858247923 sameAs 1858247923 @default.
• W1858247923 citedByCount "36" @default.
• W1858247923 countsByYear W18582479232016 @default.
• W1858247923 countsByYear W18582479232017 @default.
• W1858247923 countsByYear W18582479232018 @default.
• W1858247923 countsByYear W18582479232019 @default.
• W1858247923 countsByYear W18582479232020 @default.
• W1858247923 countsByYear W18582479232021 @default.
• W1858247923 countsByYear W18582479232022 @default.
• W1858247923 countsByYear W18582479232023 @default.
• W1858247923 crossrefType "journal-article" @default.
• W1858247923 hasAuthorship W1858247923A5011458022 @default.
• W1858247923 hasAuthorship W1858247923A5018332396 @default.
• W1858247923 hasAuthorship W1858247923A5027750651 @default.
• W1858247923 hasAuthorship W1858247923A5030940837 @default.
• W1858247923 hasAuthorship W1858247923A5031856620 @default.
• W1858247923 hasAuthorship W1858247923A5040915656 @default.
• W1858247923 hasAuthorship W1858247923A5053779035 @default.
• W1858247923 hasAuthorship W1858247923A5054748771 @default.
• W1858247923 hasAuthorship W1858247923A5070564455 @default.
• W1858247923 hasAuthorship W1858247923A5083374667 @default.
• W1858247923 hasAuthorship W1858247923A5089911913 @default.
• W1858247923 hasBestOaLocation W18582479231 @default.
• W1858247923 hasConcept C100175707 @default.
• W1858247923 hasConcept C104317684 @default.
• W1858247923 hasConcept C134459356 @default.

• next