Matches in SemOpenAlex for { <https://semopenalex.org/work/W185842893> ?p ?o ?g. }
- W185842893 endingPage "326" @default.
- W185842893 startingPage "321" @default.
- W185842893 abstract "Hepatitis B virus (HBV) infection mainly causes liver disease, including inflammation, cirrhosis, and hepatocellular carcinoma (HCC). It has been documented that prolonged hepatitis B–infected patients are unable to clear HBV from hepatocytes completely. Previous investigations have suggested that various genetic and immunologic parameters may be responsible for the induction of prolonged infection forms. Toll-like receptors (TLRs), as members of pathogen recognition receptors (PRRs), play critical roles in the recognition of viruses and the induction of appropriate immune responses. Thus, TLRs may be considered as essential sensors for the recognition of HBV and the induction of immune responses against this virus. It has been documented that TLR4 plays key roles in the detection of several microbial pathogen-associated molecular pattern molecules, including bacterial lipopolysacharide (LPS), as well as endogenous ligands (damage-associated molecular pattern molecules) and subsequently activates pro-inflammatory transcription factors in either MYD88 or TRIF dependent pathways. Previous investigations have proposed that TLR4 might be involved in appropriate immune responses against HBV. Therefore, the aim of this review is to present the recent data regarding the important roles of TLR4 in HBV recognition and regulation of immune responses against this virus, and also its roles in the pathogenesis of cirrhosis and HCC as complications of prolonged hepatitis B infections." @default.
- W185842893 created "2016-06-24" @default.
- W185842893 creator A5004798738 @default.
- W185842893 creator A5058242027 @default.
- W185842893 creator A5090508267 @default.
- W185842893 date "2014-09-01" @default.
- W185842893 modified "2023-09-27" @default.
- W185842893 title "Toll-Like Receptor 4 and Hepatitis B Infection: Molecular Mechanisms and Pathogenesis" @default.
- W185842893 cites W1480510844 @default.
- W185842893 cites W1480798236 @default.
- W185842893 cites W1498142385 @default.
- W185842893 cites W1544979073 @default.
- W185842893 cites W1603234943 @default.
- W185842893 cites W1823100012 @default.
- W185842893 cites W1893053458 @default.
- W185842893 cites W1965386943 @default.
- W185842893 cites W1968287338 @default.
- W185842893 cites W1973107366 @default.
- W185842893 cites W1973740549 @default.
- W185842893 cites W1973796113 @default.
- W185842893 cites W1974551062 @default.
- W185842893 cites W1982531307 @default.
- W185842893 cites W1988787951 @default.
- W185842893 cites W1991018031 @default.
- W185842893 cites W1993792235 @default.
- W185842893 cites W1994942139 @default.
- W185842893 cites W2005722543 @default.
- W185842893 cites W2006026833 @default.
- W185842893 cites W2023961167 @default.
- W185842893 cites W2027794518 @default.
- W185842893 cites W2034667224 @default.
- W185842893 cites W2037206310 @default.
- W185842893 cites W20377036 @default.
- W185842893 cites W2038225328 @default.
- W185842893 cites W2038891216 @default.
- W185842893 cites W2043823247 @default.
- W185842893 cites W2045151900 @default.
- W185842893 cites W2053791243 @default.
- W185842893 cites W2056918993 @default.
- W185842893 cites W2058716265 @default.
- W185842893 cites W2058989115 @default.
- W185842893 cites W2059422655 @default.
- W185842893 cites W2062835892 @default.
- W185842893 cites W2072826058 @default.
- W185842893 cites W2073960936 @default.
- W185842893 cites W2075244147 @default.
- W185842893 cites W2082890018 @default.
- W185842893 cites W2095351559 @default.
- W185842893 cites W2098891215 @default.
- W185842893 cites W2100800637 @default.
- W185842893 cites W2102838538 @default.
- W185842893 cites W2104002873 @default.
- W185842893 cites W2106694537 @default.
- W185842893 cites W2110827592 @default.
- W185842893 cites W2125792512 @default.
- W185842893 cites W2130421043 @default.
- W185842893 cites W2131750038 @default.
- W185842893 cites W2142065059 @default.
- W185842893 cites W2145333397 @default.
- W185842893 cites W2148106535 @default.
- W185842893 cites W2150900741 @default.
- W185842893 cites W2151456458 @default.
- W185842893 cites W2152972818 @default.
- W185842893 cites W2153590583 @default.
- W185842893 cites W2154932475 @default.
- W185842893 cites W2156304587 @default.
- W185842893 cites W2162615652 @default.
- W185842893 cites W4256421891 @default.
- W185842893 doi "https://doi.org/10.1089/vim.2014.0039" @default.
- W185842893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25014492" @default.
- W185842893 hasPublicationYear "2014" @default.
- W185842893 type Work @default.
- W185842893 sameAs 185842893 @default.
- W185842893 citedByCount "38" @default.
- W185842893 countsByYear W1858428932015 @default.
- W185842893 countsByYear W1858428932016 @default.
- W185842893 countsByYear W1858428932017 @default.
- W185842893 countsByYear W1858428932018 @default.
- W185842893 countsByYear W1858428932019 @default.
- W185842893 countsByYear W1858428932020 @default.
- W185842893 countsByYear W1858428932021 @default.
- W185842893 countsByYear W1858428932022 @default.
- W185842893 crossrefType "journal-article" @default.
- W185842893 hasAuthorship W185842893A5004798738 @default.
- W185842893 hasAuthorship W185842893A5058242027 @default.
- W185842893 hasAuthorship W185842893A5090508267 @default.
- W185842893 hasConcept C111289621 @default.
- W185842893 hasConcept C136449434 @default.
- W185842893 hasConcept C159047783 @default.
- W185842893 hasConcept C188899842 @default.
- W185842893 hasConcept C203014093 @default.
- W185842893 hasConcept C2522874641 @default.
- W185842893 hasConcept C2776070231 @default.
- W185842893 hasConcept C2776709828 @default.
- W185842893 hasConcept C2776914184 @default.
- W185842893 hasConcept C2777214474 @default.
- W185842893 hasConcept C2777382497 @default.
- W185842893 hasConcept C2778019345 @default.