Matches in SemOpenAlex for { <https://semopenalex.org/work/W1858458847> ?p ?o ?g. }
- W1858458847 endingPage "318" @default.
- W1858458847 startingPage "313" @default.
- W1858458847 abstract "Polylysine-DTPA-Gd, a new MR contrast agent, was injected into the aorta of rats 7 days after C6 glioblastoma was implanted in their brains; MR imaging was performed 3 days later. The imaging was done at two field strengths: (1) 1.5 T with a 3-mm slice thickness and in-plane resolutions of 600 microns and (2) 9.4 T with a 125- or 500-microns slice thickness and in-plane resolutions of 95 microns. In animals injected with polylysine-DTPA-Gd (1 microgram or more per rat), the T1-weighted images and mixed T1, T2 images of the C6 glioblastoma revealed a higher signal intensity at the marginal region between tumor and normal brain than that seen in surrounding normal brain. The central tumor region had a low signal intensity. The concentration of Gd in the C6 glioblastoma, after injection of 1 microgram polylysine-DTPA-Gd per rat, was calculated to be 0.14 mumol/l. The central tumor region also had a low signal intensity in animals that were not injected with the contrast agent, but the margin between tumor and normal brain was resolved poorly, if at all. The polylysine-DTPA-Gd revealed the microvasculature of the C6 glioblastoma in the 125-micron-thick slices obtained at 9.4 T. This is the first study to reveal the utility of the 9.4-T MR imager for examination of glioblastomas in situ and to demonstrate the utility of polylysine-DTPA-Gd as a contrast agent for the definition of the margin between glioblastoma and normal brain tissue." @default.
- W1858458847 created "2016-06-24" @default.
- W1858458847 creator A5001861589 @default.
- W1858458847 creator A5003825991 @default.
- W1858458847 creator A5015284102 @default.
- W1858458847 creator A5015592017 @default.
- W1858458847 creator A5018083870 @default.
- W1858458847 creator A5046562663 @default.
- W1858458847 creator A5059594631 @default.
- W1858458847 creator A5090306466 @default.
- W1858458847 date "1990-03-01" @default.
- W1858458847 modified "2023-09-24" @default.
- W1858458847 title "Glioblastoma multiforme: MR imaging at 1.5 and 9.4 T after injection of polylysine-DTPA-Gd in rats." @default.
- W1858458847 cites W1527973685 @default.
- W1858458847 cites W1591694957 @default.
- W1858458847 cites W1621882591 @default.
- W1858458847 cites W1787367827 @default.
- W1858458847 cites W2009812398 @default.
- W1858458847 cites W2026918336 @default.
- W1858458847 cites W2035730183 @default.
- W1858458847 cites W2050714678 @default.
- W1858458847 cites W2065974022 @default.
- W1858458847 cites W2069196966 @default.
- W1858458847 cites W2072268804 @default.
- W1858458847 cites W2073677522 @default.
- W1858458847 cites W2090584825 @default.
- W1858458847 cites W2098539860 @default.
- W1858458847 cites W2108309130 @default.
- W1858458847 cites W2165172950 @default.
- W1858458847 cites W2312658092 @default.
- W1858458847 cites W2410105433 @default.
- W1858458847 cites W2415657304 @default.
- W1858458847 cites W2743209279 @default.
- W1858458847 cites W1826522587 @default.
- W1858458847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8334681" @default.
- W1858458847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2156411" @default.
- W1858458847 hasPublicationYear "1990" @default.
- W1858458847 type Work @default.
- W1858458847 sameAs 1858458847 @default.
- W1858458847 citedByCount "3" @default.
- W1858458847 countsByYear W18584588472015 @default.
- W1858458847 countsByYear W18584588472019 @default.
- W1858458847 crossrefType "journal-article" @default.
- W1858458847 hasAuthorship W1858458847A5001861589 @default.
- W1858458847 hasAuthorship W1858458847A5003825991 @default.
- W1858458847 hasAuthorship W1858458847A5015284102 @default.
- W1858458847 hasAuthorship W1858458847A5015592017 @default.
- W1858458847 hasAuthorship W1858458847A5018083870 @default.
- W1858458847 hasAuthorship W1858458847A5046562663 @default.
- W1858458847 hasAuthorship W1858458847A5059594631 @default.
- W1858458847 hasAuthorship W1858458847A5090306466 @default.
- W1858458847 hasConcept C121332964 @default.
- W1858458847 hasConcept C126838900 @default.
- W1858458847 hasConcept C142724271 @default.
- W1858458847 hasConcept C143409427 @default.
- W1858458847 hasConcept C178790620 @default.
- W1858458847 hasConcept C185592680 @default.
- W1858458847 hasConcept C202751555 @default.
- W1858458847 hasConcept C2776194525 @default.
- W1858458847 hasConcept C2780075363 @default.
- W1858458847 hasConcept C2989005 @default.
- W1858458847 hasConcept C46141821 @default.
- W1858458847 hasConcept C502942594 @default.
- W1858458847 hasConcept C51296783 @default.
- W1858458847 hasConcept C55493867 @default.
- W1858458847 hasConcept C557651011 @default.
- W1858458847 hasConcept C71924100 @default.
- W1858458847 hasConceptScore W1858458847C121332964 @default.
- W1858458847 hasConceptScore W1858458847C126838900 @default.
- W1858458847 hasConceptScore W1858458847C142724271 @default.
- W1858458847 hasConceptScore W1858458847C143409427 @default.
- W1858458847 hasConceptScore W1858458847C178790620 @default.
- W1858458847 hasConceptScore W1858458847C185592680 @default.
- W1858458847 hasConceptScore W1858458847C202751555 @default.
- W1858458847 hasConceptScore W1858458847C2776194525 @default.
- W1858458847 hasConceptScore W1858458847C2780075363 @default.
- W1858458847 hasConceptScore W1858458847C2989005 @default.
- W1858458847 hasConceptScore W1858458847C46141821 @default.
- W1858458847 hasConceptScore W1858458847C502942594 @default.
- W1858458847 hasConceptScore W1858458847C51296783 @default.
- W1858458847 hasConceptScore W1858458847C55493867 @default.
- W1858458847 hasConceptScore W1858458847C557651011 @default.
- W1858458847 hasConceptScore W1858458847C71924100 @default.
- W1858458847 hasIssue "2" @default.
- W1858458847 hasLocation W18584588471 @default.
- W1858458847 hasOpenAccess W1858458847 @default.
- W1858458847 hasPrimaryLocation W18584588471 @default.
- W1858458847 hasRelatedWork W1572436976 @default.
- W1858458847 hasRelatedWork W1798711067 @default.
- W1858458847 hasRelatedWork W1992487604 @default.
- W1858458847 hasRelatedWork W2003546084 @default.
- W1858458847 hasRelatedWork W2004307661 @default.
- W1858458847 hasRelatedWork W2006988396 @default.
- W1858458847 hasRelatedWork W2009345244 @default.
- W1858458847 hasRelatedWork W2022309796 @default.
- W1858458847 hasRelatedWork W2045186901 @default.
- W1858458847 hasRelatedWork W2045607308 @default.
- W1858458847 hasRelatedWork W2047823702 @default.