FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W18584794> ?p ?o ?g. }

• W18584794 endingPage "1304" @default.
• W18584794 startingPage "1295" @default.
• W18584794 abstract "Background Long-term effects of lamivudine treatment on chronic hepatitis B patients without advanced disease remain unknown. Our aim was to investigate the effects of long-term lamivudine treatment and lamivudine-resistant virus (YMDD) on the development of cirrhosis and hepatocellular carcinoma (HCC) in asymptomatic patients without advanced disease. Methods One hundred and forty-two hepatitis B e antigen (HBeAg)-positive patients (median age: 33.9 years) on long-term lamivudine (median treatment duration: 89.9 months) and 124 HBeAg-positive controls (median age: 33.4 years) were prospectively followed up. Patients were monitored for the development of cirrhosis and HCC, liver biochemistry, hepatitis B virus (HBV) DNA levels, HBeAg seroconversion and hepatitis flares. YMDD mutations (YMDD-MT) were determined annually. Results Lamivudine-treated patients had a significantly lower cumulative rate of development of cirrhosis and/or HCC compared with controls ( P=0.005). YMDD-MT occurred in 76.3% of patients after 8 years of lamivudine treatment. When compared with controls and patients with YMDD-MT, patients without YMDD-MT had the greatest reduction of HBV DNA and bilirubin levels, slowest decline of albumin level, highest rate of HBeAg seroconversion and lowest risk of hepatitis flare. Patients with YMDD-MT still had a lower risk for developing cirrhosis and/or HCC ( P=0.024) and a greater HBV DNA reduction ( P=0.001) in comparison with controls. Patients with YMDD-MT and controls had a similar chance of hepatitis flares and hepatic decompensation. Conclusions Long-term lamivudine treatment was associated with a reduced chance of developing cirrhosis and HCC in patients without advanced disease. Although YMDD-MT reduced the benefits from lamivudine therapy, the outcome of these patients was still better than untreated patients." @default.
• W18584794 created "2016-06-24" @default.
• W18584794 creator A5001120790 @default.
• W18584794 creator A5020510578 @default.
• W18584794 creator A5030193303 @default.
• W18584794 creator A5046665491 @default.
• W18584794 creator A5052746623 @default.
• W18584794 creator A5066110089 @default.
• W18584794 creator A5070450933 @default.
• W18584794 creator A5080129878 @default.
• W18584794 creator A5083700089 @default.
• W18584794 creator A5091803938 @default.
• W18584794 date "2007-11-01" @default.
• W18584794 modified "2023-10-18" @default.
• W18584794 title "Long-Term Lamivudine Therapy Reduces the Risk of Long-Term Complications of Chronic Hepatitis B Infection even in Patients without Advanced Disease" @default.
• W18584794 cites W1964242359 @default.
• W18584794 cites W1969872269 @default.
• W18584794 cites W2004054613 @default.
• W18584794 cites W2004100607 @default.
• W18584794 cites W2009944703 @default.
• W18584794 cites W2014279976 @default.
• W18584794 cites W2046246882 @default.
• W18584794 cites W2049234248 @default.
• W18584794 cites W2070394152 @default.
• W18584794 cites W2082256923 @default.
• W18584794 cites W2094608386 @default.
• W18584794 cites W2102245402 @default.
• W18584794 cites W2104057484 @default.
• W18584794 cites W2104389844 @default.
• W18584794 cites W2106667426 @default.
• W18584794 cites W2127392932 @default.
• W18584794 cites W2150966027 @default.
• W18584794 cites W2161152775 @default.
• W18584794 cites W2170244859 @default.
• W18584794 cites W2319441763 @default.
• W18584794 cites W2338794667 @default.
• W18584794 cites W3094484067 @default.
• W18584794 doi "https://doi.org/10.1177/135965350701200816" @default.
• W18584794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18240869" @default.
• W18584794 hasPublicationYear "2007" @default.
• W18584794 type Work @default.
• W18584794 sameAs 18584794 @default.
• W18584794 citedByCount "222" @default.
• W18584794 countsByYear W185847942012 @default.
• W18584794 countsByYear W185847942013 @default.
• W18584794 countsByYear W185847942014 @default.
• W18584794 countsByYear W185847942015 @default.
• W18584794 countsByYear W185847942016 @default.
• W18584794 countsByYear W185847942017 @default.
• W18584794 countsByYear W185847942018 @default.
• W18584794 countsByYear W185847942019 @default.
• W18584794 countsByYear W185847942020 @default.
• W18584794 countsByYear W185847942021 @default.
• W18584794 countsByYear W185847942022 @default.
• W18584794 countsByYear W185847942023 @default.
• W18584794 crossrefType "journal-article" @default.
• W18584794 hasAuthorship W18584794A5001120790 @default.
• W18584794 hasAuthorship W18584794A5020510578 @default.
• W18584794 hasAuthorship W18584794A5030193303 @default.
• W18584794 hasAuthorship W18584794A5046665491 @default.
• W18584794 hasAuthorship W18584794A5052746623 @default.
• W18584794 hasAuthorship W18584794A5066110089 @default.
• W18584794 hasAuthorship W18584794A5070450933 @default.
• W18584794 hasAuthorship W18584794A5080129878 @default.
• W18584794 hasAuthorship W18584794A5083700089 @default.
• W18584794 hasAuthorship W18584794A5091803938 @default.
• W18584794 hasBestOaLocation W185847941 @default.
• W18584794 hasConcept C126322002 @default.
• W18584794 hasConcept C159047783 @default.
• W18584794 hasConcept C2522874641 @default.
• W18584794 hasConcept C2775940106 @default.
• W18584794 hasConcept C2777214474 @default.
• W18584794 hasConcept C2777382497 @default.
• W18584794 hasConcept C2777410769 @default.
• W18584794 hasConcept C2777451964 @default.
• W18584794 hasConcept C2777869810 @default.
• W18584794 hasConcept C2778019345 @default.
• W18584794 hasConcept C2780593183 @default.
• W18584794 hasConcept C71924100 @default.
• W18584794 hasConcept C90924648 @default.
• W18584794 hasConceptScore W18584794C126322002 @default.
• W18584794 hasConceptScore W18584794C159047783 @default.
• W18584794 hasConceptScore W18584794C2522874641 @default.
• W18584794 hasConceptScore W18584794C2775940106 @default.
• W18584794 hasConceptScore W18584794C2777214474 @default.
• W18584794 hasConceptScore W18584794C2777382497 @default.
• W18584794 hasConceptScore W18584794C2777410769 @default.
• W18584794 hasConceptScore W18584794C2777451964 @default.
• W18584794 hasConceptScore W18584794C2777869810 @default.
• W18584794 hasConceptScore W18584794C2778019345 @default.
• W18584794 hasConceptScore W18584794C2780593183 @default.
• W18584794 hasConceptScore W18584794C71924100 @default.
• W18584794 hasConceptScore W18584794C90924648 @default.
• W18584794 hasIssue "8" @default.
• W18584794 hasLocation W185847941 @default.
• W18584794 hasLocation W185847942 @default.
• W18584794 hasOpenAccess W18584794 @default.
• W18584794 hasPrimaryLocation W185847941 @default.

• next