Matches in SemOpenAlex for { <https://semopenalex.org/work/W1858598335> ?p ?o ?g. }
- W1858598335 endingPage "1617" @default.
- W1858598335 startingPage "1611" @default.
- W1858598335 abstract "Abstract Neonatal murine responses to a panel of conventional vaccines differ qualitatively from adult responses by a particular polarization toward a Th2 pattern and a frequent limitation of the Th1 and CTL responses required for protection against intracellular microorganisms. In contrast, DNA vaccines induce adult-like Th1/CTL neonatal responses against the same vaccine Ags. In this report, we show that this can be related to their content in unmethylated CpG motifs. Oligodeoxynucleotides (ODN) containing CpG motifs activate neonatal APCs to produce IL-12 in vitro and induce adult-like Th1 responses to tetanus toxoid and measles Ags in vivo, with production of IgG2a-specific Abs and adult-like secretion of IFN-γ and IL-5 by Ag-specific T cells. However, in spite of their capacity to trigger neonatal B cell proliferation in vitro, CpG-ODN only partially enhanced early life Ab responses. Finally, using Th1-driving CpG-ODN with the boosting dose of a protein vaccine was sufficient to redirect adult but not neonatally primed Th2 responses. These observations could be important for the development of novel vaccines that will have to be effective early in life." @default.
- W1858598335 created "2016-06-24" @default.
- W1858598335 creator A5017755883 @default.
- W1858598335 creator A5024771183 @default.
- W1858598335 creator A5030631117 @default.
- W1858598335 creator A5031076156 @default.
- W1858598335 creator A5034865580 @default.
- W1858598335 creator A5039812436 @default.
- W1858598335 creator A5070349994 @default.
- W1858598335 creator A5074268731 @default.
- W1858598335 date "1999-02-01" @default.
- W1858598335 modified "2023-10-11" @default.
- W1858598335 title "CpG Oligodeoxynucleotides Can Circumvent the Th2 Polarization of Neonatal Responses to Vaccines But May Fail to Fully Redirect Th2 Responses Established by Neonatal Priming" @default.
- W1858598335 cites W1544722565 @default.
- W1858598335 cites W1588809288 @default.
- W1858598335 cites W1591928190 @default.
- W1858598335 cites W1596740642 @default.
- W1858598335 cites W1602447082 @default.
- W1858598335 cites W1636901091 @default.
- W1858598335 cites W1894178301 @default.
- W1858598335 cites W1963810035 @default.
- W1858598335 cites W1969200707 @default.
- W1858598335 cites W1970206786 @default.
- W1858598335 cites W1972941257 @default.
- W1858598335 cites W1979956993 @default.
- W1858598335 cites W1986656940 @default.
- W1858598335 cites W1995881036 @default.
- W1858598335 cites W1995991884 @default.
- W1858598335 cites W2009660986 @default.
- W1858598335 cites W2010222913 @default.
- W1858598335 cites W2014495927 @default.
- W1858598335 cites W2016057259 @default.
- W1858598335 cites W2025345914 @default.
- W1858598335 cites W2027729283 @default.
- W1858598335 cites W2033441782 @default.
- W1858598335 cites W2042282764 @default.
- W1858598335 cites W2047366876 @default.
- W1858598335 cites W2050181420 @default.
- W1858598335 cites W2050548084 @default.
- W1858598335 cites W2057237586 @default.
- W1858598335 cites W2066833587 @default.
- W1858598335 cites W2067239231 @default.
- W1858598335 cites W2068441823 @default.
- W1858598335 cites W2071415293 @default.
- W1858598335 cites W2078588519 @default.
- W1858598335 cites W2079078689 @default.
- W1858598335 cites W2084147684 @default.
- W1858598335 cites W2084341407 @default.
- W1858598335 cites W2086275027 @default.
- W1858598335 cites W2090835365 @default.
- W1858598335 cites W2092128665 @default.
- W1858598335 cites W2104324781 @default.
- W1858598335 cites W2117761826 @default.
- W1858598335 cites W2132568167 @default.
- W1858598335 cites W2133592560 @default.
- W1858598335 cites W2144159905 @default.
- W1858598335 cites W2145464179 @default.
- W1858598335 cites W2158715415 @default.
- W1858598335 cites W2165645608 @default.
- W1858598335 cites W2187213934 @default.
- W1858598335 cites W2340005902 @default.
- W1858598335 cites W2429246466 @default.
- W1858598335 cites W4313333656 @default.
- W1858598335 doi "https://doi.org/10.4049/jimmunol.162.3.1611" @default.
- W1858598335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9973420" @default.
- W1858598335 hasPublicationYear "1999" @default.
- W1858598335 type Work @default.
- W1858598335 sameAs 1858598335 @default.
- W1858598335 citedByCount "125" @default.
- W1858598335 countsByYear W18585983352012 @default.
- W1858598335 countsByYear W18585983352013 @default.
- W1858598335 countsByYear W18585983352014 @default.
- W1858598335 countsByYear W18585983352015 @default.
- W1858598335 countsByYear W18585983352016 @default.
- W1858598335 countsByYear W18585983352017 @default.
- W1858598335 countsByYear W18585983352018 @default.
- W1858598335 countsByYear W18585983352019 @default.
- W1858598335 countsByYear W18585983352020 @default.
- W1858598335 countsByYear W18585983352021 @default.
- W1858598335 countsByYear W18585983352022 @default.
- W1858598335 crossrefType "journal-article" @default.
- W1858598335 hasAuthorship W1858598335A5017755883 @default.
- W1858598335 hasAuthorship W1858598335A5024771183 @default.
- W1858598335 hasAuthorship W1858598335A5030631117 @default.
- W1858598335 hasAuthorship W1858598335A5031076156 @default.
- W1858598335 hasAuthorship W1858598335A5034865580 @default.
- W1858598335 hasAuthorship W1858598335A5039812436 @default.
- W1858598335 hasAuthorship W1858598335A5070349994 @default.
- W1858598335 hasAuthorship W1858598335A5074268731 @default.
- W1858598335 hasBestOaLocation W18585983351 @default.
- W1858598335 hasConcept C100701293 @default.
- W1858598335 hasConcept C104317684 @default.
- W1858598335 hasConcept C140173407 @default.
- W1858598335 hasConcept C147969180 @default.
- W1858598335 hasConcept C150194340 @default.
- W1858598335 hasConcept C167672396 @default.
- W1858598335 hasConcept C190727270 @default.
- W1858598335 hasConcept C202751555 @default.