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- W1858807595 abstract "We investigate intercellular insulin propagation in an array of diffusively coupled cells in a discrete glucose-insulin system. The cells are connected via gap junction coupling, where nearest neighbor interactions are included. Trough the multiple scale expansion in the semi-discrete approximation, we show that the insulin dynamics can be governed by the complex Ginzburg-Landau equation. The envelop solitons of this equation are reported. Using clinical experiment values of parameters of two healthy volunteers with no family or personal history of diabetes and other endocrine diseases, we find that the hormonal waves which propagate in the system are breather-like coherent excitations. The results suggest from the biophysical point of view that the insulin propagates within plasma using both temporal and spatial dimensions in the form of localized modulated solitonic waves in order to regulate blood glucose levels. Also, hormonal waves in physiological environment travel not only across individual cells, but also from one cell to its neighbors. The result confirm also that breathers should be understood as triggering signal for the motor proteins to start moving." @default.
- W1858807595 created "2016-06-24" @default.
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- W1858807595 date "2015-08-21" @default.
- W1858807595 modified "2023-10-18" @default.
- W1858807595 title "Localized modulated waves as a mechanism of insulin propagation in diffusive glucose-insulin systems" @default.
- W1858807595 hasPublicationYear "2015" @default.
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