FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1858901635> ?p ?o ?g. }

• W1858901635 endingPage "5465" @default.
• W1858901635 startingPage "5457" @default.
• W1858901635 abstract "Neurodegeneration may occur secondary to glutamate-triggered Ca 2+ influx through any of three routes: NMDA channels, voltage-sensitive Ca 2+ channels (VSCC), and Ca 2+ -permeable AMPA/kainate channels (Ca-A/K). This study aims to examine Ca 2+ ion dynamics in the generation of excitotoxic injury by correlating the relative amounts of 45 Ca 2+ that flow into cortical neurons through each of these routes over a 10 min epoch (“10 min Ca 2+ loads;” a measure of influx rate), with resultant levels of intracellular free Ca 2+ ([Ca 2+ ] i ) and subsequent injury. Neurons possessing Ca-A/K make up a small subset (∼13%) of cortical neurons in culture, which can be identified by a histochemical stain based on kainate-stimulated Co 2+ uptake (Co 2+ (+) neurons) and which are unusually vulnerable to AMPA/kainate receptor-mediated injury. Initial studies using brief kainate exposures (to selectively destroy Co 2+ (+) neurons) along with kainate-triggered 45 Ca 2+ influx measurements suggested that kainate causes rapid Ca 2+ influx into Co 2+ (+) neurons (comparable to that caused by NMDA). Influx through both Ca-A/K and NMDA channels increased proportionately with extracellular Ca 2+ , suggesting that these channels have high Ca 2+ permeability. When cultures were subjected to exposures that gave similar 10 min Ca 2+ loads through different routes, comparable levels of injury were observed, suggesting that net intracellular Ca 2+ accumulation is a critical determinant of injury. However, the relationship between [Ca 2+ ] i and influx was less direct: although exposures that gave the lowest or highest 10 min Ca 2+ loads showed correspondingly lower or higher mean [Ca 2+ ] i responses, there appears to be a wide range of exposures over which individual neuronal differences and sequestration/buffering mechanisms obscure [Ca 2+ ] i as a reflection of influx rate." @default.
• W1858901635 created "2016-06-24" @default.
• W1858901635 creator A5039756712 @default.
• W1858901635 creator A5043030783 @default.
• W1858901635 creator A5053655423 @default.
• W1858901635 creator A5075439339 @default.
• W1858901635 date "1996-09-01" @default.
• W1858901635 modified "2023-10-15" @default.
• W1858901635 title "Ca²⁺-Permeable AMPA/Kainate and NMDA Channels: High Rate of Ca²⁺Influx Underlies Potent Induction of Injury" @default.
• W1858901635 cites W1484348587 @default.
• W1858901635 cites W1515063177 @default.
• W1858901635 cites W1519184577 @default.
• W1858901635 cites W1523671473 @default.
• W1858901635 cites W1639407471 @default.
• W1858901635 cites W1648000881 @default.
• W1858901635 cites W1850905702 @default.
• W1858901635 cites W1890775238 @default.
• W1858901635 cites W1903414318 @default.
• W1858901635 cites W1909841186 @default.
• W1858901635 cites W1920015810 @default.
• W1858901635 cites W1968354356 @default.
• W1858901635 cites W1972363392 @default.
• W1858901635 cites W1973113581 @default.
• W1858901635 cites W1974424738 @default.
• W1858901635 cites W1978348298 @default.
• W1858901635 cites W1984721901 @default.
• W1858901635 cites W1990876879 @default.
• W1858901635 cites W1997133242 @default.
• W1858901635 cites W1997862361 @default.
• W1858901635 cites W2002346436 @default.
• W1858901635 cites W2010926499 @default.
• W1858901635 cites W2028536221 @default.
• W1858901635 cites W2038575827 @default.
• W1858901635 cites W2056319105 @default.
• W1858901635 cites W2060271345 @default.
• W1858901635 cites W2063685774 @default.
• W1858901635 cites W2071479871 @default.
• W1858901635 cites W2085273994 @default.
• W1858901635 cites W2092034907 @default.
• W1858901635 cites W2097293665 @default.
• W1858901635 cites W2136504105 @default.
• W1858901635 cites W2155747798 @default.
• W1858901635 cites W2166419272 @default.
• W1858901635 cites W2236386217 @default.
• W1858901635 cites W2471927932 @default.
• W1858901635 cites W2496647201 @default.
• W1858901635 cites W4293417072 @default.
• W1858901635 cites W4298150824 @default.
• W1858901635 doi "https://doi.org/10.1523/jneurosci.16-17-05457.1996" @default.
• W1858901635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6578887" @default.
• W1858901635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8757258" @default.
• W1858901635 hasPublicationYear "1996" @default.
• W1858901635 type Work @default.
• W1858901635 sameAs 1858901635 @default.
• W1858901635 citedByCount "154" @default.
• W1858901635 countsByYear W18589016352012 @default.
• W1858901635 countsByYear W18589016352013 @default.
• W1858901635 countsByYear W18589016352014 @default.
• W1858901635 countsByYear W18589016352016 @default.
• W1858901635 countsByYear W18589016352017 @default.
• W1858901635 countsByYear W18589016352018 @default.
• W1858901635 countsByYear W18589016352019 @default.
• W1858901635 countsByYear W18589016352021 @default.
• W1858901635 countsByYear W18589016352023 @default.
• W1858901635 crossrefType "journal-article" @default.
• W1858901635 hasAuthorship W1858901635A5039756712 @default.
• W1858901635 hasAuthorship W1858901635A5043030783 @default.
• W1858901635 hasAuthorship W1858901635A5053655423 @default.
• W1858901635 hasAuthorship W1858901635A5075439339 @default.
• W1858901635 hasBestOaLocation W18589016351 @default.
• W1858901635 hasConcept C12554922 @default.
• W1858901635 hasConcept C160268369 @default.
• W1858901635 hasConcept C169760540 @default.
• W1858901635 hasConcept C170493617 @default.
• W1858901635 hasConcept C185592680 @default.
• W1858901635 hasConcept C189184402 @default.
• W1858901635 hasConcept C28406088 @default.
• W1858901635 hasConcept C55493867 @default.
• W1858901635 hasConcept C61174792 @default.
• W1858901635 hasConcept C67018056 @default.
• W1858901635 hasConcept C79879829 @default.
• W1858901635 hasConcept C86803240 @default.
• W1858901635 hasConceptScore W1858901635C12554922 @default.
• W1858901635 hasConceptScore W1858901635C160268369 @default.
• W1858901635 hasConceptScore W1858901635C169760540 @default.
• W1858901635 hasConceptScore W1858901635C170493617 @default.
• W1858901635 hasConceptScore W1858901635C185592680 @default.
• W1858901635 hasConceptScore W1858901635C189184402 @default.
• W1858901635 hasConceptScore W1858901635C28406088 @default.
• W1858901635 hasConceptScore W1858901635C55493867 @default.
• W1858901635 hasConceptScore W1858901635C61174792 @default.
• W1858901635 hasConceptScore W1858901635C67018056 @default.
• W1858901635 hasConceptScore W1858901635C79879829 @default.
• W1858901635 hasConceptScore W1858901635C86803240 @default.
• W1858901635 hasIssue "17" @default.
• W1858901635 hasLocation W18589016351 @default.
• W1858901635 hasLocation W18589016352 @default.
• W1858901635 hasLocation W18589016353 @default.

• next