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- W1859096722 abstract "Hepatitis B viruses (HBV) harboring mutations in the a-determinant of the Hepatitis B surface antigen (HBsAg) are associated with reduced reactivity of HBsAg assays.To evaluate the sensitivity and specificity of three HBsAg point-of-care tests for the detection of HBsAg of viruses harboring HBsAg mutations.A selection of 50 clinical plasma samples containing HBV with HBsAg mutations was used to evaluate the performance of three HBsAg point-of-care tests (Vikia(®), bioMérieux, Marcy-L'Étoile, France. Alere Determine HBsAg™, Iverness Biomedical Innovations, Köln, Germany. Quick Profile™, LumiQuick Diagnostics, California, USA) and compared to the ARCHITECT HBsAg Qualitative(®) assay (Abbott Laboratories, Sligo, Ireland).The sensitivity of the point-of-care tests ranged from 98% to 100%. The only false-negative result occurred using the Quick Profile™ assay with a virus harboring a D144A mutation.The evaluated point-of-care tests revealed an excellent sensitivity in detecting HBV samples harboring HBsAg mutations." @default.
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- W1859096722 date "2015-08-01" @default.
- W1859096722 modified "2023-09-24" @default.
- W1859096722 title "Performance of HBsAg point-of-care tests for detection of diagnostic escape-variants in clinical samples" @default.
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- W1859096722 doi "https://doi.org/10.1016/j.jcv.2015.05.024" @default.
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