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- W1859125670 abstract "It was demonstrated previously that the operon consisting of the non-ribosomal peptide synthetase (NRPS) gene coupled with the polyketide synthase (PKS) gene involved in cyclic heptapeptide microcystin synthesis includes two different D-amino acid synthetase genes, an epimerization domain at the 3′ end of module 2, and the racemase gene mcyF. To determine the role of mcyF in microcystin synthesis, gene-disruption and complementation analyses were carried out. Insertional mutagenesis in the mcyF gene, generated by homologous recombination, abolished only microcystin synthesis, but did not influence cell growth. Furthermore, McyF supported D-Glu-independent growth of a strain of Escherichia coli defective in D-Glu synthesis. It is concluded that mcyF is the glutamic acid racemase gene involved in the synthesis of D-Glu residues in the microcystin molecule. This is the first report of the racemase in prokaryotic NRPS." @default.
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- W1859125670 date "2001-05-01" @default.
- W1859125670 modified "2023-10-12" @default.
- W1859125670 title "Cyclic heptapeptide microcystin biosynthesis requires the glutamate racemase gene" @default.
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- W1859125670 doi "https://doi.org/10.1099/00221287-147-5-1235" @default.
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