FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1859517757> ?p ?o ?g. }

• W1859517757 endingPage "8" @default.
• W1859517757 startingPage "581" @default.
• W1859517757 abstract "The kinase activity of the BCR-ABL gene product is known to be down-regulated in K562 cells treated with low concentrations of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). The reduction of BCR-ABL kinase activity is followed by the loss of cell proliferation and progression to a more differentiated state. We have previously demonstrated that K562 cells possess protein complexes that contain p210 BCR-ABL and p160 BCR (M. L. Campbell, W. J. Li, and R. B. Arlinghaus, Oncogene, 5: 773-776, 1990). We performed experiments to determine whether BCR-ABL/BCR complexes were disrupted prior to alterations in cell growth and differentiation effects in TPA-treated K562 cells. Our results indicate that BCR-ABL/BCR complexes disappeared at precisely the same time after TPA treatment as the loss of autophosphorylation activity exhibited by total p210 BCR-ABL, which occurred 16-19 h after TPA treatment. The loss of kinase activity preceded the loss of p210 BCR by more than 24 h. A degraded form of p210 BCR-ABL (about 175 kilodaltons) accounted for the residual autophosphorylation activity seen during the later phases of kinase inactivation following TPA treatment, and this form was preferentially sequestered within BCR-ABL/BCR complexes. This altered BCR-ABL protein, although able to autophosphorylate, had reduced ability to phosphorylate p160 BCR. We conclude that 15 nM TPA treatment of K562 cells initiates effects that simultaneously interfere with the phosphorylation of p160 BCR in BCR-ABL complexes and inactivates the autophosphorylation activity of the full length BCR-ABL protein.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W1859517757 created "2016-06-24" @default.
• W1859517757 creator A5054559304 @default.
• W1859517757 creator A5055364883 @default.
• W1859517757 creator A5062372150 @default.
• W1859517757 creator A5065538168 @default.
• W1859517757 date "1993-07-01" @default.
• W1859517757 modified "2023-09-23" @default.
• W1859517757 title "Inhibition of phosphorylation of p160 BCR within p210 BCR-ABL complexes during early stages of phorbol ester-induced differentiation of K562 cells." @default.
• W1859517757 cites W125862523 @default.
• W1859517757 cites W130020229 @default.
• W1859517757 cites W1505055144 @default.
• W1859517757 cites W1510025252 @default.
• W1859517757 cites W1572314871 @default.
• W1859517757 cites W1754111038 @default.
• W1859517757 cites W1975812434 @default.
• W1859517757 cites W1984203642 @default.
• W1859517757 cites W1993282564 @default.
• W1859517757 cites W1998593414 @default.
• W1859517757 cites W2023339831 @default.
• W1859517757 cites W2034200430 @default.
• W1859517757 cites W2052569846 @default.
• W1859517757 cites W2060833726 @default.
• W1859517757 cites W2076372887 @default.
• W1859517757 cites W2115524556 @default.
• W1859517757 cites W2150937737 @default.
• W1859517757 cites W2151448460 @default.
• W1859517757 cites W2275311108 @default.
• W1859517757 cites W2303370278 @default.
• W1859517757 cites W2397218826 @default.
• W1859517757 cites W2401732302 @default.
• W1859517757 cites W2418636523 @default.
• W1859517757 cites W2462785861 @default.
• W1859517757 cites W324904487 @default.
• W1859517757 cites W2092158388 @default.
• W1859517757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8398898" @default.
• W1859517757 hasPublicationYear "1993" @default.
• W1859517757 type Work @default.
• W1859517757 sameAs 1859517757 @default.
• W1859517757 citedByCount "6" @default.
• W1859517757 countsByYear W18595177572016 @default.
• W1859517757 countsByYear W18595177572017 @default.
• W1859517757 crossrefType "journal-article" @default.
• W1859517757 hasAuthorship W1859517757A5054559304 @default.
• W1859517757 hasAuthorship W1859517757A5055364883 @default.
• W1859517757 hasAuthorship W1859517757A5062372150 @default.
• W1859517757 hasAuthorship W1859517757A5065538168 @default.
• W1859517757 hasConcept C11960822 @default.
• W1859517757 hasConcept C125418893 @default.
• W1859517757 hasConcept C150109051 @default.
• W1859517757 hasConcept C153911025 @default.
• W1859517757 hasConcept C170493617 @default.
• W1859517757 hasConcept C171122931 @default.
• W1859517757 hasConcept C184235292 @default.
• W1859517757 hasConcept C203014093 @default.
• W1859517757 hasConcept C2778461978 @default.
• W1859517757 hasConcept C42362537 @default.
• W1859517757 hasConcept C43907098 @default.
• W1859517757 hasConcept C502942594 @default.
• W1859517757 hasConcept C55493867 @default.
• W1859517757 hasConcept C62478195 @default.
• W1859517757 hasConcept C86803240 @default.
• W1859517757 hasConcept C95444343 @default.
• W1859517757 hasConcept C97029542 @default.
• W1859517757 hasConceptScore W1859517757C11960822 @default.
• W1859517757 hasConceptScore W1859517757C125418893 @default.
• W1859517757 hasConceptScore W1859517757C150109051 @default.
• W1859517757 hasConceptScore W1859517757C153911025 @default.
• W1859517757 hasConceptScore W1859517757C170493617 @default.
• W1859517757 hasConceptScore W1859517757C171122931 @default.
• W1859517757 hasConceptScore W1859517757C184235292 @default.
• W1859517757 hasConceptScore W1859517757C203014093 @default.
• W1859517757 hasConceptScore W1859517757C2778461978 @default.
• W1859517757 hasConceptScore W1859517757C42362537 @default.
• W1859517757 hasConceptScore W1859517757C43907098 @default.
• W1859517757 hasConceptScore W1859517757C502942594 @default.
• W1859517757 hasConceptScore W1859517757C55493867 @default.
• W1859517757 hasConceptScore W1859517757C62478195 @default.
• W1859517757 hasConceptScore W1859517757C86803240 @default.
• W1859517757 hasConceptScore W1859517757C95444343 @default.
• W1859517757 hasConceptScore W1859517757C97029542 @default.
• W1859517757 hasIssue "7" @default.
• W1859517757 hasLocation W18595177571 @default.
• W1859517757 hasOpenAccess W1859517757 @default.
• W1859517757 hasPrimaryLocation W18595177571 @default.
• W1859517757 hasRelatedWork W1859517757 @default.
• W1859517757 hasRelatedWork W2021296556 @default.
• W1859517757 hasRelatedWork W2022192516 @default.
• W1859517757 hasRelatedWork W2071274119 @default.
• W1859517757 hasRelatedWork W2075155467 @default.
• W1859517757 hasRelatedWork W2380680924 @default.
• W1859517757 hasRelatedWork W2421017417 @default.
• W1859517757 hasRelatedWork W2441586703 @default.
• W1859517757 hasRelatedWork W2962637587 @default.
• W1859517757 hasRelatedWork W4285094426 @default.
• W1859517757 hasVolume "4" @default.
• W1859517757 isParatext "false" @default.
• W1859517757 isRetracted "false" @default.

• next