FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1859793957> ?p ?o ?g. }

• W1859793957 endingPage "e0135993" @default.
• W1859793957 startingPage "e0135993" @default.
• W1859793957 abstract "Pennogenyl saponins are the active compounds of large number of plant species and consequently many polyherbal formulations. Hence, great interest has been shown in their characterization and in the investigation of their pharmacological and biological properties, especially anticancer. This present study reports on the evaluation of cytotoxic effects and explanation of the molecular mechanisms of action of the two pennogenyl saponins (PS 1 and PS 2) isolated from Paris quadrifolia L. rhizomes on human cervical adenocarcinoma cell line HeLa. To determine the viability of the cells treated with the compounds we used real-time cell proliferation analysis and found that the pennogenyl saponins PS 1 and PS 2 strongly inhibited the tumor cells growth with IC50 values of 1.11 ± 0.04 μg/ml and 0.87 ± 0.05 μg/ml, respectively. The flow cytometry analysis indicated that the two compounds induced apoptosis in a dose-dependent manner and decreased mitochondrial membrane potential in HeLa cells in the early stage of apoptosis. Quantitative PCR and Western Blot analysis showed that the two saponins significantly increased mRNA expression of FADD and BID as well as induced caspase-8 via increased of procaspase-8 processing in the treated cells. The results of this study suggest that both the extrinsic death receptor and intrinsic mitochondrial pathways are involved in the programmed cell death." @default.
• W1859793957 created "2016-06-24" @default.
• W1859793957 creator A5024006453 @default.
• W1859793957 creator A5029304341 @default.
• W1859793957 creator A5036813232 @default.
• W1859793957 creator A5046657896 @default.
• W1859793957 creator A5063658424 @default.
• W1859793957 creator A5075559987 @default.
• W1859793957 creator A5088337816 @default.
• W1859793957 date "2015-08-21" @default.
• W1859793957 modified "2023-09-25" @default.
• W1859793957 title "Pennogenyl Saponins from Paris quadrifolia L. Induce Extrinsic and Intrinsic Pathway of Apoptosis in Human Cervical Cancer HeLa Cells" @default.
• W1859793957 cites W125106425 @default.
• W1859793957 cites W1506057870 @default.
• W1859793957 cites W1550247880 @default.
• W1859793957 cites W1559486600 @default.
• W1859793957 cites W1607777232 @default.
• W1859793957 cites W1745634660 @default.
• W1859793957 cites W1836073275 @default.
• W1859793957 cites W1935383169 @default.
• W1859793957 cites W1963529845 @default.
• W1859793957 cites W1969551758 @default.
• W1859793957 cites W1972733192 @default.
• W1859793957 cites W1973109581 @default.
• W1859793957 cites W1974167529 @default.
• W1859793957 cites W1975238333 @default.
• W1859793957 cites W1975897321 @default.
• W1859793957 cites W1977978386 @default.
• W1859793957 cites W1988418086 @default.
• W1859793957 cites W1997178247 @default.
• W1859793957 cites W2004431524 @default.
• W1859793957 cites W2008212059 @default.
• W1859793957 cites W2008757142 @default.
• W1859793957 cites W2009183786 @default.
• W1859793957 cites W2010053288 @default.
• W1859793957 cites W2012173926 @default.
• W1859793957 cites W2015323619 @default.
• W1859793957 cites W2017333472 @default.
• W1859793957 cites W2017867735 @default.
• W1859793957 cites W2026618442 @default.
• W1859793957 cites W2035143278 @default.
• W1859793957 cites W2040094445 @default.
• W1859793957 cites W2041233832 @default.
• W1859793957 cites W2041684308 @default.
• W1859793957 cites W2049112891 @default.
• W1859793957 cites W2067777097 @default.
• W1859793957 cites W2072380594 @default.
• W1859793957 cites W2075036139 @default.
• W1859793957 cites W2078532650 @default.
• W1859793957 cites W2093745691 @default.
• W1859793957 cites W2099818615 @default.
• W1859793957 cites W2107686964 @default.
• W1859793957 cites W2107825983 @default.
• W1859793957 cites W2110891265 @default.
• W1859793957 cites W2114570899 @default.
• W1859793957 cites W2126376871 @default.
• W1859793957 cites W2128178072 @default.
• W1859793957 cites W2154063020 @default.
• W1859793957 cites W2159212282 @default.
• W1859793957 cites W2169670265 @default.
• W1859793957 cites W2326785651 @default.
• W1859793957 cites W3004118171 @default.
• W1859793957 cites W4240479615 @default.
• W1859793957 doi "https://doi.org/10.1371/journal.pone.0135993" @default.
• W1859793957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4546673" @default.
• W1859793957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26295969" @default.
• W1859793957 hasPublicationYear "2015" @default.
• W1859793957 type Work @default.
• W1859793957 sameAs 1859793957 @default.
• W1859793957 citedByCount "17" @default.
• W1859793957 countsByYear W18597939572016 @default.
• W1859793957 countsByYear W18597939572017 @default.
• W1859793957 countsByYear W18597939572018 @default.
• W1859793957 countsByYear W18597939572019 @default.
• W1859793957 countsByYear W18597939572020 @default.
• W1859793957 countsByYear W18597939572021 @default.
• W1859793957 countsByYear W18597939572022 @default.
• W1859793957 crossrefType "journal-article" @default.
• W1859793957 hasAuthorship W1859793957A5024006453 @default.
• W1859793957 hasAuthorship W1859793957A5029304341 @default.
• W1859793957 hasAuthorship W1859793957A5036813232 @default.
• W1859793957 hasAuthorship W1859793957A5046657896 @default.
• W1859793957 hasAuthorship W1859793957A5063658424 @default.
• W1859793957 hasAuthorship W1859793957A5075559987 @default.
• W1859793957 hasAuthorship W1859793957A5088337816 @default.
• W1859793957 hasBestOaLocation W18597939571 @default.
• W1859793957 hasConcept C104317684 @default.
• W1859793957 hasConcept C1491633281 @default.
• W1859793957 hasConcept C153911025 @default.
• W1859793957 hasConcept C154317977 @default.
• W1859793957 hasConcept C185592680 @default.
• W1859793957 hasConcept C190283241 @default.
• W1859793957 hasConcept C202751555 @default.
• W1859793957 hasConcept C2776055636 @default.
• W1859793957 hasConcept C2776415932 @default.
• W1859793957 hasConcept C2777366897 @default.
• W1859793957 hasConcept C31573885 @default.
• W1859793957 hasConcept C54355233 @default.

• next