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- W1859966504 abstract "We propose to establish a cancer biomarker based on the unique optical-mechanical signatures of cancer cells measured in a noncontact, label-free manner by optical interferometry. Using wide-field interferometric phase microscopy (IPM), implemented by a portable, off-axis, common-path and low-coherence interferometric module, we quantitatively measured the time-dependent, nanometer-scale optical thickness fluctuation maps of live cells in vitro. We found that cancer cells fluctuate significantly more than healthy cells, and that metastatic cancer cells fluctuate significantly more than primary cancer cells. Atomic force microscopy (AFM) measurements validated the results. Our study shows the potential of IPM as a simple clinical tool for aiding in diagnosis and monitoring of cancer." @default.
- W1859966504 created "2016-06-24" @default.
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- W1859966504 date "2013-04-15" @default.
- W1859966504 modified "2023-10-16" @default.
- W1859966504 title "Optical-mechanical signatures of cancer cells based on fluctuation profiles measured by interferometry" @default.
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- W1859966504 doi "https://doi.org/10.1002/jbio.201300019" @default.
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