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- W1860095720 abstract "Publisher Summary This chapter discusses the medicinal chemistry of 1-Benzazepines. Many 1-benzazepines having various substituents possess interesting biological actions. Most of the actions of particular interest have been reported in the past decade. Numerous 1-benzazepine derivatives fused to an additional ring, especially with an aromatic ring, have been reported to exhibit a variety of biological activities, particularly on the central nervous system. The chapter presents the literature of the medicinal chemistry of those 1-benzazepine derivatives consisting of a fused two-ring system and the compounds without such framework to gain a better understanding of drug designs for the 1-benzazepine derivatives discussed. A variety of synthetic methods for 1-benzazepines has been reported and comprehensively reviewed. The main methods that appear to be of preparative value in the synthesis of 1-benzazepines are also summarized. The earliest synthetic method for 1-benzazepine derivatives was a ring closure of o -substituted anilines by C–N bond formation." @default.
- W1860095720 created "2016-06-24" @default.
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- W1860095720 date "1990-01-01" @default.
- W1860095720 modified "2023-10-18" @default.
- W1860095720 title "3 Medicinal Chemistry of 1-Benzazepines" @default.
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- W1860095720 doi "https://doi.org/10.1016/s0079-6468(08)70290-x" @default.
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