FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1860197952> ?p ?o ?g. }

• W1860197952 abstract "Theoretically human embryonic stem cells (hESCs) have the capacity to self-renew and differentiate into all human cell types. Therefore, the greatest promise of hESCs-based therapy is to replace the damaged tissues of patients suffering from traumatic or degenerative diseases by the exact same type of cells derived from hESCs. Allograft immune rejection is one of the obstacles for hESCs-based clinical applications. Human leukocyte antigen (HLA) II leads to CD4(+) T cells-mediated allograft rejection. Hence, we focus on optimizing hESCs for clinic application through gene modification.Transcription activator-like effector nucleases (TALENs) were used to target MHC class II transactivator (CIITA) in hESCs efficiently. CIITA (-/-) hESCs did not show any difference in the differentiation potential and self-renewal capacity. Dendritic cells (DCs) derived from CIITA (-/-) hESCs expressed CD83 and CD86 but without the constitutive HLA II. Fibroblasts derived from CIITA (-/-) hESCs were powerless in IFN-γ inducible expression of HLA II.We generated HLA II defected hESCs via deleting CIITA, a master regulator of constitutive and IFN-γ inducible expression of HLA II genes. CIITA (-/-) hESCs can differentiate into tissue cells with non-HLA II expression. It's promising that CIITA (-/-) hESCs-derived cells could be used in cell therapy (e.g., T cells and DCs) and escape the attack of receptors' CD4(+) T cells, which are the main effector cells of cellular immunity in allograft." @default.
• W1860197952 created "2016-06-24" @default.
• W1860197952 creator A5013249999 @default.
• W1860197952 creator A5044787100 @default.
• W1860197952 creator A5058943360 @default.
• W1860197952 creator A5059411979 @default.
• W1860197952 creator A5060969271 @default.
• W1860197952 creator A5074493384 @default.
• W1860197952 creator A5083534218 @default.
• W1860197952 date "2015-10-27" @default.
• W1860197952 modified "2023-09-30" @default.
• W1860197952 title "Functional disruption of human leukocyte antigen II in human embryonic stem cell" @default.
• W1860197952 cites W1920211008 @default.
• W1860197952 cites W1973651953 @default.
• W1860197952 cites W1985690388 @default.
• W1860197952 cites W1994170225 @default.
• W1860197952 cites W1995744312 @default.
• W1860197952 cites W2005163476 @default.
• W1860197952 cites W2010822377 @default.
• W1860197952 cites W2015347622 @default.
• W1860197952 cites W2015848550 @default.
• W1860197952 cites W2041772815 @default.
• W1860197952 cites W2048908321 @default.
• W1860197952 cites W2069848002 @default.
• W1860197952 cites W2076618068 @default.
• W1860197952 cites W2078951305 @default.
• W1860197952 cites W2082019843 @default.
• W1860197952 cites W2086600633 @default.
• W1860197952 cites W2086943348 @default.
• W1860197952 cites W2087396302 @default.
• W1860197952 cites W2099560139 @default.
• W1860197952 cites W2100412095 @default.
• W1860197952 cites W2112444085 @default.
• W1860197952 cites W2114838239 @default.
• W1860197952 cites W2122937303 @default.
• W1860197952 cites W2130011407 @default.
• W1860197952 cites W2133341341 @default.
• W1860197952 cites W2147258683 @default.
• W1860197952 cites W2151517892 @default.
• W1860197952 cites W2156546436 @default.
• W1860197952 cites W242967828 @default.
• W1860197952 doi "https://doi.org/10.1186/s40659-015-0051-6" @default.
• W1860197952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4624597" @default.
• W1860197952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26506955" @default.
• W1860197952 hasPublicationYear "2015" @default.
• W1860197952 type Work @default.
• W1860197952 sameAs 1860197952 @default.
• W1860197952 citedByCount "33" @default.
• W1860197952 countsByYear W18601979522016 @default.
• W1860197952 countsByYear W18601979522017 @default.
• W1860197952 countsByYear W18601979522018 @default.
• W1860197952 countsByYear W18601979522019 @default.
• W1860197952 countsByYear W18601979522020 @default.
• W1860197952 countsByYear W18601979522021 @default.
• W1860197952 countsByYear W18601979522022 @default.
• W1860197952 countsByYear W18601979522023 @default.
• W1860197952 crossrefType "journal-article" @default.
• W1860197952 hasAuthorship W1860197952A5013249999 @default.
• W1860197952 hasAuthorship W1860197952A5044787100 @default.
• W1860197952 hasAuthorship W1860197952A5058943360 @default.
• W1860197952 hasAuthorship W1860197952A5059411979 @default.
• W1860197952 hasAuthorship W1860197952A5060969271 @default.
• W1860197952 hasAuthorship W1860197952A5074493384 @default.
• W1860197952 hasAuthorship W1860197952A5083534218 @default.
• W1860197952 hasBestOaLocation W18601979521 @default.
• W1860197952 hasConcept C104317684 @default.
• W1860197952 hasConcept C145103041 @default.
• W1860197952 hasConcept C147483822 @default.
• W1860197952 hasConcept C188280979 @default.
• W1860197952 hasConcept C203014093 @default.
• W1860197952 hasConcept C2775890610 @default.
• W1860197952 hasConcept C2776090121 @default.
• W1860197952 hasConcept C2778814158 @default.
• W1860197952 hasConcept C28328180 @default.
• W1860197952 hasConcept C54355233 @default.
• W1860197952 hasConcept C86803240 @default.
• W1860197952 hasConcept C8891405 @default.
• W1860197952 hasConcept C95444343 @default.
• W1860197952 hasConceptScore W1860197952C104317684 @default.
• W1860197952 hasConceptScore W1860197952C145103041 @default.
• W1860197952 hasConceptScore W1860197952C147483822 @default.
• W1860197952 hasConceptScore W1860197952C188280979 @default.
• W1860197952 hasConceptScore W1860197952C203014093 @default.
• W1860197952 hasConceptScore W1860197952C2775890610 @default.
• W1860197952 hasConceptScore W1860197952C2776090121 @default.
• W1860197952 hasConceptScore W1860197952C2778814158 @default.
• W1860197952 hasConceptScore W1860197952C28328180 @default.
• W1860197952 hasConceptScore W1860197952C54355233 @default.
• W1860197952 hasConceptScore W1860197952C86803240 @default.
• W1860197952 hasConceptScore W1860197952C8891405 @default.
• W1860197952 hasConceptScore W1860197952C95444343 @default.
• W1860197952 hasIssue "1" @default.
• W1860197952 hasLocation W18601979521 @default.
• W1860197952 hasLocation W18601979522 @default.
• W1860197952 hasLocation W18601979523 @default.
• W1860197952 hasLocation W18601979524 @default.
• W1860197952 hasLocation W18601979525 @default.
• W1860197952 hasLocation W18601979526 @default.
• W1860197952 hasOpenAccess W1860197952 @default.
• W1860197952 hasPrimaryLocation W18601979521 @default.

• next