Matches in SemOpenAlex for { <https://semopenalex.org/work/W1860278004> ?p ?o ?g. }
- W1860278004 endingPage "1270" @default.
- W1860278004 startingPage "1256" @default.
- W1860278004 abstract "DNA methylation is essential for protecting the mammalian germline against transposons. When DNA methylation-based transposon control is defective, meiotic chromosome pairing is consistently impaired during spermatogenesis: How and why meiosis is vulnerable to transposon activity is unknown. Using two DNA methylation-deficient backgrounds, the Dnmt3L and Miwi2 mutant mice, we reveal that DNA methylation is largely dispensable for silencing transposons before meiosis onset. After this, it becomes crucial to back up to a developmentally programmed H3K9me2 loss. Massive retrotransposition does not occur following transposon derepression, but the meiotic chromatin landscape is profoundly affected. Indeed, H3K4me3 marks gained over transcriptionally active transposons correlate with formation of SPO11-dependent double-strand breaks and recruitment of the DMC1 repair enzyme in Dnmt3L(-/-) meiotic cells, whereas these features are normally exclusive to meiotic recombination hot spots. Here, we demonstrate that DNA methylation restrains transposons from adopting chromatin characteristics amenable to meiotic recombination, which we propose prevents the occurrence of erratic chromosomal events." @default.
- W1860278004 created "2016-06-24" @default.
- W1860278004 creator A5008737442 @default.
- W1860278004 creator A5035193301 @default.
- W1860278004 creator A5047327833 @default.
- W1860278004 creator A5056848730 @default.
- W1860278004 creator A5072227443 @default.
- W1860278004 creator A5076019953 @default.
- W1860278004 creator A5084451701 @default.
- W1860278004 date "2015-06-15" @default.
- W1860278004 modified "2023-10-15" @default.
- W1860278004 title "DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination" @default.
- W1860278004 cites W1509378838 @default.
- W1860278004 cites W1511424866 @default.
- W1860278004 cites W1528634627 @default.
- W1860278004 cites W1963998725 @default.
- W1860278004 cites W1966150502 @default.
- W1860278004 cites W1967224500 @default.
- W1860278004 cites W1968421891 @default.
- W1860278004 cites W1970283686 @default.
- W1860278004 cites W1972809713 @default.
- W1860278004 cites W1973596898 @default.
- W1860278004 cites W1974115274 @default.
- W1860278004 cites W1976021779 @default.
- W1860278004 cites W1985575613 @default.
- W1860278004 cites W1987752798 @default.
- W1860278004 cites W1987882116 @default.
- W1860278004 cites W1988823631 @default.
- W1860278004 cites W1990654003 @default.
- W1860278004 cites W1990699200 @default.
- W1860278004 cites W1992031539 @default.
- W1860278004 cites W1997758697 @default.
- W1860278004 cites W2001341582 @default.
- W1860278004 cites W2001806616 @default.
- W1860278004 cites W2011927108 @default.
- W1860278004 cites W2012334640 @default.
- W1860278004 cites W2012612933 @default.
- W1860278004 cites W2013550946 @default.
- W1860278004 cites W2014988420 @default.
- W1860278004 cites W2015402753 @default.
- W1860278004 cites W2023844789 @default.
- W1860278004 cites W2024459631 @default.
- W1860278004 cites W2032700279 @default.
- W1860278004 cites W2036785063 @default.
- W1860278004 cites W2036994672 @default.
- W1860278004 cites W2037570580 @default.
- W1860278004 cites W2039196620 @default.
- W1860278004 cites W2040891039 @default.
- W1860278004 cites W2044994347 @default.
- W1860278004 cites W2047657819 @default.
- W1860278004 cites W2051541780 @default.
- W1860278004 cites W2054305990 @default.
- W1860278004 cites W2060234119 @default.
- W1860278004 cites W2060903701 @default.
- W1860278004 cites W2071365780 @default.
- W1860278004 cites W2071936353 @default.
- W1860278004 cites W2075224242 @default.
- W1860278004 cites W2077053535 @default.
- W1860278004 cites W2077908123 @default.
- W1860278004 cites W2080722280 @default.
- W1860278004 cites W2083151255 @default.
- W1860278004 cites W2096196036 @default.
- W1860278004 cites W2110100152 @default.
- W1860278004 cites W2111801210 @default.
- W1860278004 cites W2119390857 @default.
- W1860278004 cites W2119828212 @default.
- W1860278004 cites W2121818828 @default.
- W1860278004 cites W2126637770 @default.
- W1860278004 cites W2131226513 @default.
- W1860278004 cites W2136828783 @default.
- W1860278004 cites W2138919235 @default.
- W1860278004 cites W2140997010 @default.
- W1860278004 cites W2150288025 @default.
- W1860278004 cites W2150335729 @default.
- W1860278004 cites W2151464048 @default.
- W1860278004 cites W2152188491 @default.
- W1860278004 cites W2152239989 @default.
- W1860278004 cites W2158361859 @default.
- W1860278004 cites W2160563322 @default.
- W1860278004 cites W2164247158 @default.
- W1860278004 cites W2164953929 @default.
- W1860278004 cites W2165290876 @default.
- W1860278004 cites W2165879373 @default.
- W1860278004 cites W2170551349 @default.
- W1860278004 doi "https://doi.org/10.1101/gad.257840.114" @default.
- W1860278004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4495397" @default.
- W1860278004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26109049" @default.
- W1860278004 hasPublicationYear "2015" @default.
- W1860278004 type Work @default.
- W1860278004 sameAs 1860278004 @default.
- W1860278004 citedByCount "144" @default.
- W1860278004 countsByYear W18602780042015 @default.
- W1860278004 countsByYear W18602780042016 @default.
- W1860278004 countsByYear W18602780042017 @default.
- W1860278004 countsByYear W18602780042018 @default.
- W1860278004 countsByYear W18602780042019 @default.
- W1860278004 countsByYear W18602780042020 @default.
- W1860278004 countsByYear W18602780042021 @default.