FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1860315828> ?p ?o ?g. }

• W1860315828 endingPage "1180" @default.
• W1860315828 startingPage "1174" @default.
• W1860315828 abstract "Previous studies have demonstrated that the lack of lumican delayed corneal wound healing in lumican-null (Lum(-/-) ) mice. This defect is rescued by the addition of glycosylated lumican core protein to the injured corneas.We examined the hypothesis that lumican is also required for the healing of cutaneous wounds using Lum(-/-) mice.We demonstrated the basic thinner skin phenotypes in Lum(-/-) mice at different time points and the changes in arrangement of collagen fibres by transmission electron microscopy (TEM). A full skin thickness wound was generated by punch biopsy (6 mm diameter) in experimental Lum(-/-) and wild-type mice. The closure of injured skin was measured after various periods of time (3, 6, 12, 18 days). Specimens of injured and uninjured skin (serving as control) were then subjected to morphological examination with haematoxylin and eosin and Masson trichrome stains, and by TEM. Immunohistochemical staining with anti-CD68 antibody was used to assess the presence of macrophages in injured skin healing for various periods of time. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to elucidate the transforming growth factor (TGF)-β1-induced myofibroblast phenotypic genes.Skin of adult Lum(-/-) mice (3 months and older) was much thinner (40% less) than that of age-matched wild-type mice. This phenomenon was aggravated in older mice. TEM revealed disoriented and irregular collagen fibrils in the dermis of Lum(-/-) mice. Delayed wound healing with an increase in inflammatory macrophages was compatible with the delayed response of the expression of TGF-β1, type I collagen α1 and fibronectin at the mRNA level by semiquantitative RT-PCR in the Lum(-/-) mice.Our data demonstrate that lumican plays pivotal roles in skin collagen fibrillogenesis and wound healing." @default.
• W1860315828 created "2016-06-24" @default.
• W1860315828 creator A5004676801 @default.
• W1860315828 creator A5010885279 @default.
• W1860315828 creator A5011682601 @default.
• W1860315828 creator A5016281673 @default.
• W1860315828 creator A5016366854 @default.
• W1860315828 creator A5019281695 @default.
• W1860315828 creator A5035280460 @default.
• W1860315828 creator A5070265821 @default.
• W1860315828 creator A5083539700 @default.
• W1860315828 date "2010-11-04" @default.
• W1860315828 modified "2023-10-06" @default.
• W1860315828 title "Impaired skin wound healing in lumican-null mice" @default.
• W1860315828 cites W1533083198 @default.
• W1860315828 cites W1571929977 @default.
• W1860315828 cites W1574083809 @default.
• W1860315828 cites W1971954485 @default.
• W1860315828 cites W1981285854 @default.
• W1860315828 cites W1989074212 @default.
• W1860315828 cites W1992593527 @default.
• W1860315828 cites W1993054842 @default.
• W1860315828 cites W2001293142 @default.
• W1860315828 cites W2002642600 @default.
• W1860315828 cites W2009061578 @default.
• W1860315828 cites W2009967947 @default.
• W1860315828 cites W2010619374 @default.
• W1860315828 cites W2014893350 @default.
• W1860315828 cites W2015425516 @default.
• W1860315828 cites W2022107266 @default.
• W1860315828 cites W2034135211 @default.
• W1860315828 cites W2036341761 @default.
• W1860315828 cites W2040460288 @default.
• W1860315828 cites W2041591721 @default.
• W1860315828 cites W2062265758 @default.
• W1860315828 cites W2072304039 @default.
• W1860315828 cites W2081498604 @default.
• W1860315828 cites W2086730539 @default.
• W1860315828 cites W2093909277 @default.
• W1860315828 cites W2098662346 @default.
• W1860315828 cites W2104390119 @default.
• W1860315828 cites W2120347833 @default.
• W1860315828 cites W2133159567 @default.
• W1860315828 cites W2137178267 @default.
• W1860315828 cites W2151846229 @default.
• W1860315828 cites W2159058635 @default.
• W1860315828 cites W3022355476 @default.
• W1860315828 doi "https://doi.org/10.1111/j.1365-2133.2010.10008.x" @default.
• W1860315828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20738297" @default.
• W1860315828 hasPublicationYear "2010" @default.
• W1860315828 type Work @default.
• W1860315828 sameAs 1860315828 @default.
• W1860315828 citedByCount "50" @default.
• W1860315828 countsByYear W18603158282012 @default.
• W1860315828 countsByYear W18603158282013 @default.
• W1860315828 countsByYear W18603158282014 @default.
• W1860315828 countsByYear W18603158282015 @default.
• W1860315828 countsByYear W18603158282016 @default.
• W1860315828 countsByYear W18603158282017 @default.
• W1860315828 countsByYear W18603158282018 @default.
• W1860315828 countsByYear W18603158282019 @default.
• W1860315828 countsByYear W18603158282020 @default.
• W1860315828 countsByYear W18603158282021 @default.
• W1860315828 countsByYear W18603158282022 @default.
• W1860315828 countsByYear W18603158282023 @default.
• W1860315828 crossrefType "journal-article" @default.
• W1860315828 hasAuthorship W1860315828A5004676801 @default.
• W1860315828 hasAuthorship W1860315828A5010885279 @default.
• W1860315828 hasAuthorship W1860315828A5011682601 @default.
• W1860315828 hasAuthorship W1860315828A5016281673 @default.
• W1860315828 hasAuthorship W1860315828A5016366854 @default.
• W1860315828 hasAuthorship W1860315828A5019281695 @default.
• W1860315828 hasAuthorship W1860315828A5035280460 @default.
• W1860315828 hasAuthorship W1860315828A5070265821 @default.
• W1860315828 hasAuthorship W1860315828A5083539700 @default.
• W1860315828 hasConcept C105702510 @default.
• W1860315828 hasConcept C134018914 @default.
• W1860315828 hasConcept C142724271 @default.
• W1860315828 hasConcept C163031210 @default.
• W1860315828 hasConcept C189165786 @default.
• W1860315828 hasConcept C190567982 @default.
• W1860315828 hasConcept C203014093 @default.
• W1860315828 hasConcept C204232928 @default.
• W1860315828 hasConcept C207865475 @default.
• W1860315828 hasConcept C2777624698 @default.
• W1860315828 hasConcept C2779335624 @default.
• W1860315828 hasConcept C2779457992 @default.
• W1860315828 hasConcept C2779794767 @default.
• W1860315828 hasConcept C2779797417 @default.
• W1860315828 hasConcept C2780269544 @default.
• W1860315828 hasConcept C2780550940 @default.
• W1860315828 hasConcept C2780559512 @default.
• W1860315828 hasConcept C71924100 @default.
• W1860315828 hasConcept C86492073 @default.
• W1860315828 hasConcept C86803240 @default.
• W1860315828 hasConcept C95444343 @default.
• W1860315828 hasConceptScore W1860315828C105702510 @default.
• W1860315828 hasConceptScore W1860315828C134018914 @default.

• next