Matches in SemOpenAlex for { <https://semopenalex.org/work/W1860395514> ?p ?o ?g. }
- W1860395514 endingPage "18" @default.
- W1860395514 startingPage "9" @default.
- W1860395514 abstract "To clarify the full range of benefits and adverse consequences of Helicobacter pylori eradication as a strategy for gastric cancer prevention, the community-based intervention trial was launched in Linqu County, China.A total of 184,786 residents aged 25-54 years were enrolled in this trial and received (13)C-urea breath test. H. pylori positive participants were assigned into two groups, either receiving a 10-day quadruple anti-H. pylori treatment or lookalike placebos together with a single dosage of omeprazole and bismuth.The prevalence of H. pylori in trial participants was 57.6%. A total of 94,101 subjects completed the treatment. The overall H. pylori eradication rate was 72.9% in the active group. Gender, body mass index, history of stomach disease, baseline delta over baseline-value of (13)C-urea breath test, missed medication doses, smoking and drinking were independent predictors of eradication failure. The missed doses and high baseline delta over baseline-value were important contributors in men and women (all Ptrend<0.001). However, a dose-response relationship between failure rate and smoking or drinking index was found in men (all Ptrend<0.001), while high body mass index (Ptrend<0.001) and history of stomach disease were significant predictors in women. The treatment failure rate increased up to 48.8% (OR 2.87, 95% CI 2.24 to 3.68) in men and 39.4% (OR 2.67, 95% CI 1.61 to 4.42) in women with multiple factors combined.This large community-based intervention trial to eradicate H. pylori is feasible and acceptable. The findings of this trial lead to a distinct evaluation of factors influencing eradication that should be generally considered for future eradication therapies.ChiCTR-TRC-10000979 in accordance with WHO ICTRP requirements." @default.
- W1860395514 created "2016-06-24" @default.
- W1860395514 creator A5007680363 @default.
- W1860395514 creator A5011216679 @default.
- W1860395514 creator A5011765753 @default.
- W1860395514 creator A5012621209 @default.
- W1860395514 creator A5017408026 @default.
- W1860395514 creator A5017942200 @default.
- W1860395514 creator A5018544690 @default.
- W1860395514 creator A5021625669 @default.
- W1860395514 creator A5022802322 @default.
- W1860395514 creator A5026667360 @default.
- W1860395514 creator A5027763220 @default.
- W1860395514 creator A5040038040 @default.
- W1860395514 creator A5042015617 @default.
- W1860395514 creator A5042643943 @default.
- W1860395514 creator A5057720144 @default.
- W1860395514 creator A5059940437 @default.
- W1860395514 creator A5064510089 @default.
- W1860395514 creator A5071330246 @default.
- W1860395514 creator A5080681893 @default.
- W1860395514 creator A5087078716 @default.
- W1860395514 creator A5088425411 @default.
- W1860395514 creator A5091899058 @default.
- W1860395514 date "2015-05-18" @default.
- W1860395514 modified "2023-10-17" @default.
- W1860395514 title "A large randomised controlled intervention trial to prevent gastric cancer by eradication of<i>Helicobacter pylori</i>in Linqu County, China: baseline results and factors affecting the eradication" @default.
- W1860395514 cites W163912360 @default.
- W1860395514 cites W183961050 @default.
- W1860395514 cites W1963789497 @default.
- W1860395514 cites W1968211961 @default.
- W1860395514 cites W1969297582 @default.
- W1860395514 cites W1970761867 @default.
- W1860395514 cites W1974497208 @default.
- W1860395514 cites W1978709295 @default.
- W1860395514 cites W1993539567 @default.
- W1860395514 cites W2011917942 @default.
- W1860395514 cites W2029990428 @default.
- W1860395514 cites W2038457830 @default.
- W1860395514 cites W2047195668 @default.
- W1860395514 cites W2056131972 @default.
- W1860395514 cites W2057483058 @default.
- W1860395514 cites W2062351205 @default.
- W1860395514 cites W2082611553 @default.
- W1860395514 cites W2086896742 @default.
- W1860395514 cites W2099744244 @default.
- W1860395514 cites W2100000977 @default.
- W1860395514 cites W2105811856 @default.
- W1860395514 cites W2117879926 @default.
- W1860395514 cites W2118342728 @default.
- W1860395514 cites W2123978826 @default.
- W1860395514 cites W2125173799 @default.
- W1860395514 cites W2126547130 @default.
- W1860395514 cites W2129783761 @default.
- W1860395514 cites W2139464969 @default.
- W1860395514 cites W2144285906 @default.
- W1860395514 cites W2145653414 @default.
- W1860395514 cites W2149132763 @default.
- W1860395514 cites W2153754546 @default.
- W1860395514 cites W2159189190 @default.
- W1860395514 cites W2166531443 @default.
- W1860395514 cites W2170048761 @default.
- W1860395514 cites W2171165592 @default.
- W1860395514 doi "https://doi.org/10.1136/gutjnl-2015-309197" @default.
- W1860395514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25986943" @default.
- W1860395514 hasPublicationYear "2015" @default.
- W1860395514 type Work @default.
- W1860395514 sameAs 1860395514 @default.
- W1860395514 citedByCount "127" @default.
- W1860395514 countsByYear W18603955142015 @default.
- W1860395514 countsByYear W18603955142016 @default.
- W1860395514 countsByYear W18603955142017 @default.
- W1860395514 countsByYear W18603955142018 @default.
- W1860395514 countsByYear W18603955142019 @default.
- W1860395514 countsByYear W18603955142020 @default.
- W1860395514 countsByYear W18603955142021 @default.
- W1860395514 countsByYear W18603955142022 @default.
- W1860395514 countsByYear W18603955142023 @default.
- W1860395514 crossrefType "journal-article" @default.
- W1860395514 hasAuthorship W1860395514A5007680363 @default.
- W1860395514 hasAuthorship W1860395514A5011216679 @default.
- W1860395514 hasAuthorship W1860395514A5011765753 @default.
- W1860395514 hasAuthorship W1860395514A5012621209 @default.
- W1860395514 hasAuthorship W1860395514A5017408026 @default.
- W1860395514 hasAuthorship W1860395514A5017942200 @default.
- W1860395514 hasAuthorship W1860395514A5018544690 @default.
- W1860395514 hasAuthorship W1860395514A5021625669 @default.
- W1860395514 hasAuthorship W1860395514A5022802322 @default.
- W1860395514 hasAuthorship W1860395514A5026667360 @default.
- W1860395514 hasAuthorship W1860395514A5027763220 @default.
- W1860395514 hasAuthorship W1860395514A5040038040 @default.
- W1860395514 hasAuthorship W1860395514A5042015617 @default.
- W1860395514 hasAuthorship W1860395514A5042643943 @default.
- W1860395514 hasAuthorship W1860395514A5057720144 @default.
- W1860395514 hasAuthorship W1860395514A5059940437 @default.
- W1860395514 hasAuthorship W1860395514A5064510089 @default.
- W1860395514 hasAuthorship W1860395514A5071330246 @default.
- W1860395514 hasAuthorship W1860395514A5080681893 @default.