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• W1860785890 endingPage "905" @default.
• W1860785890 startingPage "2895" @default.
• W1860785890 abstract "In previous work, we generated four IgM, five IgG1, and one IgA1 mAbs to rabies virus using B cells from four subjects vaccinated with inactivated rabies virus, a thymus-dependent (TD) mosaic Ag, and sequenced the mAb V(H)DJ(H) genes. Here, we have cloned the V kappa J kappa and V lambda J lambda genes to complete the primary structure of the Ag-binding site of these mAbs. While the anti-rabies virus mAb selection of VA genes (2e.2.2 twice, DPL11, and DPL23) reflected the representation of the V lambda genes in the human haploid genome (stochastic utilization), that of V kappa genes (O2/O12 twice, O8/O18, A3/A19, A27, and L2) did not (p = 0.0018) (nonstochastic utilization). Furthermore, the selection of both V kappa and V lambda genes by the anti-rabies virus mAbs vastly overlapped with that of 557 assorted V kappa J kappa rearrangements, that of 253 V lambda J lambda rearrangements in lambda-type gammopathies, and that of other Abs to thymus-dependent Ags, including 23 anti-HIV mAbs and 51 rheumatoid factors, but differed from that of 43 Abs to Haemophilus influenzae type b polysaccharide, a prototypic thymus-independent (TI) Ag. The anti-rabies virus mAb V kappa J kappa and V lambda J lambda segments displayed variable numbers of somatic mutations, which, in mAb58 and the virus-neutralizing mAb57, entailed a significant concentration of amino acid replacements in the complementarity-determining regions (p = 0.0028 and p = 0.0023, respectively), suggesting a selection by Ag. This Ag-dependent somatic selection process was superimposed on a somatic diversification process that occurred at the stage of B cell receptor for Ag rearrangement, and that entailed V gene 3' truncation and N nucleotide additions to yield heterogeneous CDR3s." @default.
• W1860785890 created "2016-06-24" @default.
• W1860785890 creator A5046159238 @default.
• W1860785890 creator A5053550877 @default.
• W1860785890 creator A5064135895 @default.
• W1860785890 creator A5083322320 @default.
• W1860785890 creator A5084173464 @default.
• W1860785890 date "1998-09-15" @default.
• W1860785890 modified "2023-09-23" @default.
• W1860785890 title "Clonal analysis of a human antibody response. III. Nucleotide sequences of monoclonal IgM, IgG, and IgA to rabies virus reveal restricted V kappa gene utilization, junctional V kappa J kappa and V lambda J lambda diversity, and somatic hypermutation." @default.
• W1860785890 cites W113943006 @default.
• W1860785890 cites W1484092314 @default.
• W1860785890 cites W1486034860 @default.
• W1860785890 cites W1487862126 @default.
• W1860785890 cites W1501528121 @default.
• W1860785890 cites W1508918383 @default.
• W1860785890 cites W1510972797 @default.
• W1860785890 cites W1513171403 @default.
• W1860785890 cites W1514521170 @default.
• W1860785890 cites W1519282847 @default.
• W1860785890 cites W1520426897 @default.
• W1860785890 cites W1526532212 @default.
• W1860785890 cites W1528800735 @default.
• W1860785890 cites W1538857361 @default.
• W1860785890 cites W1547299437 @default.
• W1860785890 cites W1549704190 @default.
• W1860785890 cites W1553946161 @default.
• W1860785890 cites W1556273434 @default.
• W1860785890 cites W1560008042 @default.
• W1860785890 cites W1569409312 @default.
• W1860785890 cites W1575299344 @default.
• W1860785890 cites W1583479835 @default.
• W1860785890 cites W1601859667 @default.
• W1860785890 cites W169978917 @default.
• W1860785890 cites W170628193 @default.
• W1860785890 cites W1833972154 @default.
• W1860785890 cites W1879654670 @default.
• W1860785890 cites W1890717569 @default.
• W1860785890 cites W1966880762 @default.
• W1860785890 cites W1971429636 @default.
• W1860785890 cites W1982679430 @default.
• W1860785890 cites W1994390883 @default.
• W1860785890 cites W1995193402 @default.
• W1860785890 cites W2000756150 @default.
• W1860785890 cites W2005566446 @default.
• W1860785890 cites W2009293121 @default.
• W1860785890 cites W2009519711 @default.
• W1860785890 cites W2017384825 @default.
• W1860785890 cites W2019785396 @default.
• W1860785890 cites W2020166995 @default.
• W1860785890 cites W2022486030 @default.
• W1860785890 cites W2032045623 @default.
• W1860785890 cites W2033183720 @default.
• W1860785890 cites W2038967224 @default.
• W1860785890 cites W2039414258 @default.
• W1860785890 cites W2041281119 @default.
• W1860785890 cites W2046819104 @default.
• W1860785890 cites W2050591560 @default.
• W1860785890 cites W2051397298 @default.
• W1860785890 cites W2055804586 @default.
• W1860785890 cites W2058493142 @default.
• W1860785890 cites W2062419478 @default.
• W1860785890 cites W2063199750 @default.
• W1860785890 cites W2064302901 @default.
• W1860785890 cites W2064823965 @default.
• W1860785890 cites W2069519516 @default.
• W1860785890 cites W2070301660 @default.
• W1860785890 cites W2071198743 @default.
• W1860785890 cites W2074534136 @default.
• W1860785890 cites W2077344802 @default.
• W1860785890 cites W2080273416 @default.
• W1860785890 cites W2082451158 @default.
• W1860785890 cites W2083363168 @default.
• W1860785890 cites W2084492613 @default.
• W1860785890 cites W2090841599 @default.
• W1860785890 cites W2100267828 @default.
• W1860785890 cites W2102366445 @default.
• W1860785890 cites W2105029898 @default.
• W1860785890 cites W2107131610 @default.
• W1860785890 cites W2128904113 @default.
• W1860785890 cites W2155950102 @default.
• W1860785890 cites W2158528683 @default.
• W1860785890 cites W2164444189 @default.
• W1860785890 cites W2164920330 @default.
• W1860785890 cites W2416014223 @default.
• W1860785890 cites W367527820 @default.
• W1860785890 cites W573085220 @default.
• W1860785890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9743351" @default.
• W1860785890 hasPublicationYear "1998" @default.
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