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- W1861008753 abstract "16546 Background: Up to 85% of all BCC are localized in head and neck region and can usually be cured by surgery. The recurrent BCC (rBCC) may grow under normal skin and have a more agressive behaviour. Sometimes, when it is discovered could be unresectable or lead to a great deformity if removed. Methods: Between December 2000 and December 2003 we have treated 3 patients (pts), 2 male/1 female with invasive rBCC with osseous involvement in retro-orbital region, invasion of paranasal and ethmoidal sinus, nasal cavity and orbital bone. Medium size 7 cm. Two pts have already received radiotherapy (RXT) one and two years before. Therapy consisted of docetaxel 35 mg/m2 and cisplatin 25 mg/m2 D1,D8 and D15 with one or two weeks interval. Results: They achieved complete response at the 6th cycle and received more 3 cycles- total of nine cycles.The pt that not had RXT before, received 5000 cGy as consolidation. Reconstrutive surgery was not necessary and two pts recovered the vision of the affected eye. Toxicity was mild in all pts with no grade 3 or 4. All pts are in complete remission until now. Conclusions: Contrary to previous reports, advanced BCC is responsive to chemotherapy with a longlasting response even after RXT, improving the quality of life and perhaps survival of pts with rBCC. No significant financial relationships to disclose." @default.
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- W1861008753 date "2007-06-20" @default.
- W1861008753 modified "2023-10-14" @default.
- W1861008753 title "Chemotherapy for advanced and recurring basal cell carcinoma (BCC) with docetaxel and cisplatin" @default.
- W1861008753 doi "https://doi.org/10.1200/jco.2007.25.18_suppl.16546" @default.
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