FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1861365302> ?p ?o ?g. }

• W1861365302 endingPage "3903" @default.
• W1861365302 startingPage "3897" @default.
• W1861365302 abstract "To obtain nontoxic and highly immunogenic lipopolysaccharide (LPS) for immunization, we incorporated Neisseria meningitidis LPS into liposomes. Native LPS and its salts were incorporated by the method of dehydration-rehydration of vesicles or prolonged cosonication. The most complete incorporation of LPS into liposomes and a decrease in toxicity were achieved by the method of dehydration-rehydration of vesicles. Three forms of LPS (H+ form, Mg2+ salt, and triethanolamine salt) showed different solubilities in water, the acidic form of LPS, with the most pronounced hydrophobic properties, being capable of practically complete association with liposomal membranes. An evaluation of the activity of liposomal LPS in vitro (by the Limulus amoebocyte test) and in vivo (by monitoring the pyrogenic reaction in rabbits) revealed a decrease in endotoxin activity of up to 1,000-fold. In addition, the pyrogenic activity of liposomal LPS was comparable to that of a meningococcal polysaccharide vaccine. Liposomes had a pronounced adjuvant effect on the immune response to LPS. Thus, the level of anti-LPS plaque-forming cells in the spleens of mice immunized with liposomal LPS was 1 order of magnitude higher and could be observed for a longer time (until day 21, i.e., the term of observation) than in mice immunized with free LPS. The same regularity was revealed in a study done with an enzyme-linked immunosorbent assay. This study also established that antibodies induced by immunization belonged to the immunoglobulin M and G classes, which are capable of prolonged circulation. Moreover, liposomal LPS induced a pronounced immune response in CBA/N mice (defective in B lymphocytes of the LyB-5+ subpopulation). The latter results indicate that the immunogenic action of liposomal LPS occurs at an early age." @default.
• W1861365302 created "2016-06-24" @default.
• W1861365302 creator A5003299873 @default.
• W1861365302 creator A5010194515 @default.
• W1861365302 creator A5020337614 @default.
• W1861365302 creator A5022110817 @default.
• W1861365302 creator A5032106365 @default.
• W1861365302 creator A5065290878 @default.
• W1861365302 creator A5067665580 @default.
• W1861365302 creator A5071217208 @default.
• W1861365302 creator A5075619683 @default.
• W1861365302 creator A5087311135 @default.
• W1861365302 date "1992-09-01" @default.
• W1861365302 modified "2023-10-18" @default.
• W1861365302 title "Toxicity and immunogenicity of Neisseria meningitidis lipopolysaccharide incorporated into liposomes" @default.
• W1861365302 cites W1834148623 @default.
• W1861365302 cites W1888965171 @default.
• W1861365302 cites W1894042961 @default.
• W1861365302 cites W1915794092 @default.
• W1861365302 cites W1923128572 @default.
• W1861365302 cites W1934293658 @default.
• W1861365302 cites W1963895695 @default.
• W1861365302 cites W1980701926 @default.
• W1861365302 cites W1987680345 @default.
• W1861365302 cites W2016325703 @default.
• W1861365302 cites W2033616674 @default.
• W1861365302 cites W2047432839 @default.
• W1861365302 cites W2059340457 @default.
• W1861365302 cites W2065934807 @default.
• W1861365302 cites W2076774563 @default.
• W1861365302 cites W2089179708 @default.
• W1861365302 cites W2094369301 @default.
• W1861365302 cites W2098621347 @default.
• W1861365302 cites W2117542724 @default.
• W1861365302 cites W2126493655 @default.
• W1861365302 cites W2163662951 @default.
• W1861365302 cites W2329352287 @default.
• W1861365302 doi "https://doi.org/10.1128/iai.60.9.3897-3903.1992" @default.
• W1861365302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/257405" @default.
• W1861365302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1500196" @default.
• W1861365302 hasPublicationYear "1992" @default.
• W1861365302 type Work @default.
• W1861365302 sameAs 1861365302 @default.
• W1861365302 citedByCount "28" @default.
• W1861365302 countsByYear W18613653022012 @default.
• W1861365302 countsByYear W18613653022013 @default.
• W1861365302 countsByYear W18613653022014 @default.
• W1861365302 countsByYear W18613653022021 @default.
• W1861365302 crossrefType "journal-article" @default.
• W1861365302 hasAuthorship W1861365302A5003299873 @default.
• W1861365302 hasAuthorship W1861365302A5010194515 @default.
• W1861365302 hasAuthorship W1861365302A5020337614 @default.
• W1861365302 hasAuthorship W1861365302A5022110817 @default.
• W1861365302 hasAuthorship W1861365302A5032106365 @default.
• W1861365302 hasAuthorship W1861365302A5065290878 @default.
• W1861365302 hasAuthorship W1861365302A5067665580 @default.
• W1861365302 hasAuthorship W1861365302A5071217208 @default.
• W1861365302 hasAuthorship W1861365302A5075619683 @default.
• W1861365302 hasAuthorship W1861365302A5087311135 @default.
• W1861365302 hasBestOaLocation W18613653021 @default.
• W1861365302 hasConcept C144464004 @default.
• W1861365302 hasConcept C151730666 @default.
• W1861365302 hasConcept C185154212 @default.
• W1861365302 hasConcept C185592680 @default.
• W1861365302 hasConcept C203014093 @default.
• W1861365302 hasConcept C2776040547 @default.
• W1861365302 hasConcept C2776487282 @default.
• W1861365302 hasConcept C2777863537 @default.
• W1861365302 hasConcept C2778458888 @default.
• W1861365302 hasConcept C2778754761 @default.
• W1861365302 hasConcept C2780868878 @default.
• W1861365302 hasConcept C523546767 @default.
• W1861365302 hasConcept C54355233 @default.
• W1861365302 hasConcept C55493867 @default.
• W1861365302 hasConcept C86803240 @default.
• W1861365302 hasConcept C8891405 @default.
• W1861365302 hasConcept C89423630 @default.
• W1861365302 hasConcept C98274493 @default.
• W1861365302 hasConceptScore W1861365302C144464004 @default.
• W1861365302 hasConceptScore W1861365302C151730666 @default.
• W1861365302 hasConceptScore W1861365302C185154212 @default.
• W1861365302 hasConceptScore W1861365302C185592680 @default.
• W1861365302 hasConceptScore W1861365302C203014093 @default.
• W1861365302 hasConceptScore W1861365302C2776040547 @default.
• W1861365302 hasConceptScore W1861365302C2776487282 @default.
• W1861365302 hasConceptScore W1861365302C2777863537 @default.
• W1861365302 hasConceptScore W1861365302C2778458888 @default.
• W1861365302 hasConceptScore W1861365302C2778754761 @default.
• W1861365302 hasConceptScore W1861365302C2780868878 @default.
• W1861365302 hasConceptScore W1861365302C523546767 @default.
• W1861365302 hasConceptScore W1861365302C54355233 @default.
• W1861365302 hasConceptScore W1861365302C55493867 @default.
• W1861365302 hasConceptScore W1861365302C86803240 @default.
• W1861365302 hasConceptScore W1861365302C8891405 @default.
• W1861365302 hasConceptScore W1861365302C89423630 @default.
• W1861365302 hasConceptScore W1861365302C98274493 @default.
• W1861365302 hasIssue "9" @default.
• W1861365302 hasLocation W18613653021 @default.

• next