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- W1862015311 endingPage "C521" @default.
- W1862015311 startingPage "C511" @default.
- W1862015311 abstract "The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic development and tissue homeostasis. Notably, comprehensive genetic studies in Drosophila and mice in the past decades have demonstrated the crucial role of Wnt signaling in intestinal stem cell maintenance by regulating proliferation, differentiation, and cell-fate decisions. Wnt signaling has also been implicated in a variety of cancers and other diseases. Loss of the Wnt pathway negative regulator adenomatous polyposis coli (APC) is the hallmark of human colorectal cancers (CRC). Recent advances in high-throughput sequencing further reveal many novel recurrent Wnt pathway mutations in addition to the well-characterized APC and β-catenin mutations in CRC. Despite attractive strategies to develop drugs for Wnt signaling, major hurdles in therapeutic intervention of the pathway persist. Here we discuss the Wnt-activating mechanisms in CRC and review the current advances and challenges in drug discovery." @default.
- W1862015311 created "2016-06-24" @default.
- W1862015311 creator A5011331927 @default.
- W1862015311 creator A5020214405 @default.
- W1862015311 creator A5030010349 @default.
- W1862015311 date "2015-10-15" @default.
- W1862015311 modified "2023-10-11" @default.
- W1862015311 title "Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms" @default.
- W1862015311 cites W1480165016 @default.
- W1862015311 cites W1539988273 @default.
- W1862015311 cites W1564357553 @default.
- W1862015311 cites W1586218645 @default.
- W1862015311 cites W1598540600 @default.
- W1862015311 cites W1655178001 @default.
- W1862015311 cites W1943978442 @default.
- W1862015311 cites W1967137553 @default.
- W1862015311 cites W1969534054 @default.
- W1862015311 cites W1973712079 @default.
- W1862015311 cites W1975993620 @default.
- W1862015311 cites W1976116300 @default.
- W1862015311 cites W1979410891 @default.
- W1862015311 cites W1980383179 @default.
- W1862015311 cites W1982603620 @default.
- W1862015311 cites W1986300386 @default.
- W1862015311 cites W1986724654 @default.
- W1862015311 cites W1986937402 @default.
- W1862015311 cites W1987887347 @default.
- W1862015311 cites W1989215255 @default.
- W1862015311 cites W1990518021 @default.
- W1862015311 cites W1994029539 @default.
- W1862015311 cites W1995004385 @default.
- W1862015311 cites W1995819860 @default.
- W1862015311 cites W2000042026 @default.
- W1862015311 cites W2001258296 @default.
- W1862015311 cites W2001505418 @default.
- W1862015311 cites W2002858128 @default.
- W1862015311 cites W2004349922 @default.
- W1862015311 cites W2005440429 @default.
- W1862015311 cites W2006239354 @default.
- W1862015311 cites W2006259718 @default.
- W1862015311 cites W2007990146 @default.
- W1862015311 cites W2008187359 @default.
- W1862015311 cites W2010174939 @default.
- W1862015311 cites W2020178657 @default.
- W1862015311 cites W2020940130 @default.
- W1862015311 cites W2026254108 @default.
- W1862015311 cites W2027150010 @default.
- W1862015311 cites W2028243804 @default.
- W1862015311 cites W2029222627 @default.
- W1862015311 cites W2030213691 @default.
- W1862015311 cites W2031714747 @default.
- W1862015311 cites W2033106726 @default.
- W1862015311 cites W2034696212 @default.
- W1862015311 cites W2034820020 @default.
- W1862015311 cites W2035078576 @default.
- W1862015311 cites W2035192365 @default.
- W1862015311 cites W2036541245 @default.
- W1862015311 cites W2040942754 @default.
- W1862015311 cites W2042082068 @default.
- W1862015311 cites W2044413378 @default.
- W1862015311 cites W2045828622 @default.
- W1862015311 cites W2046634347 @default.
- W1862015311 cites W2049346003 @default.
- W1862015311 cites W2050862757 @default.
- W1862015311 cites W2053354626 @default.
- W1862015311 cites W2055258210 @default.
- W1862015311 cites W2056833504 @default.
- W1862015311 cites W2057257265 @default.
- W1862015311 cites W2058559777 @default.
- W1862015311 cites W2059813946 @default.
- W1862015311 cites W2064027874 @default.
- W1862015311 cites W2069750786 @default.
- W1862015311 cites W2072778582 @default.
- W1862015311 cites W2074175804 @default.
- W1862015311 cites W2078060536 @default.
- W1862015311 cites W2079754100 @default.
- W1862015311 cites W2080912877 @default.
- W1862015311 cites W2081985759 @default.
- W1862015311 cites W2082396328 @default.
- W1862015311 cites W2083457841 @default.
- W1862015311 cites W2085153797 @default.
- W1862015311 cites W2086742737 @default.
- W1862015311 cites W2087995751 @default.
- W1862015311 cites W2090636859 @default.
- W1862015311 cites W2090789702 @default.
- W1862015311 cites W2091118082 @default.
- W1862015311 cites W2091356364 @default.
- W1862015311 cites W2097903769 @default.
- W1862015311 cites W2101095306 @default.
- W1862015311 cites W2101889783 @default.
- W1862015311 cites W2104819469 @default.
- W1862015311 cites W2105240743 @default.
- W1862015311 cites W2105372476 @default.
- W1862015311 cites W2105953048 @default.
- W1862015311 cites W2110386568 @default.
- W1862015311 cites W2113493324 @default.
- W1862015311 cites W2114525915 @default.
- W1862015311 cites W2114921350 @default.