Matches in SemOpenAlex for { <https://semopenalex.org/work/W1862027878> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1862027878 endingPage "2206" @default.
- W1862027878 startingPage "2197" @default.
- W1862027878 abstract "To determine the association between adherence, dose and low-density lipoprotein (LDL) cholesterol response in patients with type 2 diabetes initiating statin treatment.This cohort study was performed using data for 2007-2012 from the Groningen Initiative to Analyse Type 2 Diabetes Treatment (GIANTT) database. The association between adherence to a standard-dose statin and LDL cholesterol response was assessed using linear regression, adjusting for covariates. The effect of low-dose versus standard-dose was assessed in a propensity-score matched cohort. Adherence rates, defined as the proportion of days covered (PDC), were estimated between statin initiation and LDL outcome measurement.LDL cholesterol level at follow-up.The effect of adherence on LDL cholesterol response, measured in 2160 patients, was dependent on the baseline LDL cholesterol level. For patients with a baseline LDL cholesterol of 3.7 mmol/l and an adherence rate of 80%, a 40% reduction in LDL cholesterol was predicted. In the matched sample of 1144 patients, the treatment dose showed a difference in impact on the outcome for adherence rates higher than 50%. It was estimated that a patient with a baseline LDL cholesterol of 3.7 mmol/l will need an adherence rate of at least 76% on low-dose and 63% on standard-dose treatment to reach the LDL cholesterol target of 2.5 mmol/l.Adherence was measured as the PDC, which is known to overestimate actual adherence. Also, we were not able to adjust for lifestyle factors.We determined the concurrent effect of treatment adherence and dose on LDL cholesterol outcomes. Given the adherence levels seen in clinical practice, diabetes patients initiating statin treatment are at high risk of not reaching the recommended cholesterol target, especially when they start on a low-dose statin." @default.
- W1862027878 created "2016-06-24" @default.
- W1862027878 creator A5012967322 @default.
- W1862027878 creator A5029966007 @default.
- W1862027878 creator A5033079155 @default.
- W1862027878 creator A5042644478 @default.
- W1862027878 date "2015-10-19" @default.
- W1862027878 modified "2023-09-27" @default.
- W1862027878 title "Adherence to standard-dose or low-dose statin treatment and low-density lipoprotein cholesterol response in type 2 diabetes patients" @default.
- W1862027878 cites W1511488739 @default.
- W1862027878 cites W1555265704 @default.
- W1862027878 cites W1948458971 @default.
- W1862027878 cites W1974491934 @default.
- W1862027878 cites W1981535076 @default.
- W1862027878 cites W1982697486 @default.
- W1862027878 cites W1997113038 @default.
- W1862027878 cites W1997458600 @default.
- W1862027878 cites W2013345160 @default.
- W1862027878 cites W2019618316 @default.
- W1862027878 cites W2036193982 @default.
- W1862027878 cites W2057531842 @default.
- W1862027878 cites W2062437217 @default.
- W1862027878 cites W2110171695 @default.
- W1862027878 cites W2113297655 @default.
- W1862027878 cites W2116404316 @default.
- W1862027878 cites W2126049444 @default.
- W1862027878 cites W2129037537 @default.
- W1862027878 cites W2133649500 @default.
- W1862027878 cites W2134159541 @default.
- W1862027878 cites W2141584391 @default.
- W1862027878 cites W2156174993 @default.
- W1862027878 cites W2166894879 @default.
- W1862027878 doi "https://doi.org/10.1185/03007995.2015.1092126" @default.
- W1862027878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26359331" @default.
- W1862027878 hasPublicationYear "2015" @default.
- W1862027878 type Work @default.
- W1862027878 sameAs 1862027878 @default.
- W1862027878 citedByCount "8" @default.
- W1862027878 countsByYear W18620278782016 @default.
- W1862027878 countsByYear W18620278782018 @default.
- W1862027878 countsByYear W18620278782019 @default.
- W1862027878 countsByYear W18620278782021 @default.
- W1862027878 countsByYear W18620278782022 @default.
- W1862027878 countsByYear W18620278782023 @default.
- W1862027878 crossrefType "journal-article" @default.
- W1862027878 hasAuthorship W1862027878A5012967322 @default.
- W1862027878 hasAuthorship W1862027878A5029966007 @default.
- W1862027878 hasAuthorship W1862027878A5033079155 @default.
- W1862027878 hasAuthorship W1862027878A5042644478 @default.
- W1862027878 hasBestOaLocation W18620278782 @default.
- W1862027878 hasConcept C126322002 @default.
- W1862027878 hasConcept C134018914 @default.
- W1862027878 hasConcept C17923572 @default.
- W1862027878 hasConcept C2776839432 @default.
- W1862027878 hasConcept C2777180221 @default.
- W1862027878 hasConcept C2777482532 @default.
- W1862027878 hasConcept C2778163477 @default.
- W1862027878 hasConcept C555293320 @default.
- W1862027878 hasConcept C71924100 @default.
- W1862027878 hasConcept C72563966 @default.
- W1862027878 hasConcept C90924648 @default.
- W1862027878 hasConceptScore W1862027878C126322002 @default.
- W1862027878 hasConceptScore W1862027878C134018914 @default.
- W1862027878 hasConceptScore W1862027878C17923572 @default.
- W1862027878 hasConceptScore W1862027878C2776839432 @default.
- W1862027878 hasConceptScore W1862027878C2777180221 @default.
- W1862027878 hasConceptScore W1862027878C2777482532 @default.
- W1862027878 hasConceptScore W1862027878C2778163477 @default.
- W1862027878 hasConceptScore W1862027878C555293320 @default.
- W1862027878 hasConceptScore W1862027878C71924100 @default.
- W1862027878 hasConceptScore W1862027878C72563966 @default.
- W1862027878 hasConceptScore W1862027878C90924648 @default.
- W1862027878 hasIssue "12" @default.
- W1862027878 hasLocation W18620278781 @default.
- W1862027878 hasLocation W18620278782 @default.
- W1862027878 hasLocation W18620278783 @default.
- W1862027878 hasLocation W18620278784 @default.
- W1862027878 hasOpenAccess W1862027878 @default.
- W1862027878 hasPrimaryLocation W18620278781 @default.
- W1862027878 hasRelatedWork W1972175381 @default.
- W1862027878 hasRelatedWork W2003150205 @default.
- W1862027878 hasRelatedWork W2005998106 @default.
- W1862027878 hasRelatedWork W2019813684 @default.
- W1862027878 hasRelatedWork W2032958076 @default.
- W1862027878 hasRelatedWork W2035331946 @default.
- W1862027878 hasRelatedWork W2075372262 @default.
- W1862027878 hasRelatedWork W2127396703 @default.
- W1862027878 hasRelatedWork W2153591790 @default.
- W1862027878 hasRelatedWork W2158288207 @default.
- W1862027878 hasVolume "31" @default.
- W1862027878 isParatext "false" @default.
- W1862027878 isRetracted "false" @default.
- W1862027878 magId "1862027878" @default.
- W1862027878 workType "article" @default.