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- W1862155340 abstract "Resume Objectif : Decrire le cas d’un adolescent qui a developpe une toxicite au voriconazole intraveineux alors qu’il presentait de nombreux facteurs pouvant en influencer la pharmacocinetique. Resume du cas : Il s’agit d’un patient de 17 ans suivi apres une greffe de moelle osseuse, hemodialyse trois fois par semaine, traite au voriconazole intraveineux pour une infection fongique pulmonaire qui a developpe des troubles visuels et des hallucinations. Les concentrations plasmatiques de voriconazole chez ce patient etaient alors anormalement elevees. Aucune interaction medicamenteuse ne pouvait expliquer des valeurs aussi elevees. Un genotypage du CYP2C19 a revele que le patient possedait le CYP2C19 (681G >A) responsable d’un phenotype de metaboliseur lent heterozygote. Discussion : L’association entre les effets indesirables subis par le patient et le voriconazole est probable. Les donnees probantes sur ce sujet, le lien temporel et l’exclusion des autres causes possibles parlent en faveur de cette association. Conclusion : Ce cas demontre la necessite de faire le suivi des dosages de voriconazole et l’importance de la pharmacologie dans les soins directs dispenses aux patients. Abstract Objective: To describe the case of an adolescent that developed toxicity to the use of intravenous voriconazole. Case summary: A 17-year old patient with post stem cell transplant, on hemodialysis three times a week, was treated with intravenous voriconazole for a fungal infection in the lungs. He developed visual disturbances and hallucinations. Plasma drug levels of voriconazole were reported to be high. No drug interaction could explain these elevated values. Genotyping of CYP2C19 revealed that the patient was a heterozygous slow metabolizer, as a result of having CYP2C19 (681G>A). Discussion: There is an association between the adverse effects experienced by the patient and the administration of voriconazole. The temporal link and the exclusion of other likely causes favour this association. Conclusion: This case demonstrates the necessity of monitoring voriconazole levels and the importance of collaboration with clinical pharmacologists. Key words: Adverse effects, cytochrome, drug levels, hallucinations, hemodialysis, pharmacokinetics, polymorphism, slow metabolizer, toxicity, visual disturbances, voriconazole." @default.
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- W1862155340 date "2013-01-01" @default.
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- W1862155340 title "Hallucinations secondaires au voriconazole chez un adolescent : pertinence du suivi pharmacocinétique" @default.
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