Matches in SemOpenAlex for { <https://semopenalex.org/work/W1862207360> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1862207360 endingPage "734" @default.
- W1862207360 startingPage "728" @default.
- W1862207360 abstract "Specific high-affinity low-capacity binding of human chorionic gonadotropin (hCG) and lutropin (hLH) was demonstrated in the plasma membrane fractions of human corpora lutea. The number of binding sites for both hormones increased from early to late luteal phase, whereas regressing corpus luteum from proliferative phase did not bind either hormone. On the basis of apparent dissociation constants the affinity of the receptor for hLH is highest during early luteal phase and decreases toward the end of the cycle, which may reflect an increasing insensitivity of the corpus luteum to circulating hLH. By contrast, the affinity of the receptor for hCG is highest in the midluteal phase. There are gonadotropin binding sites in the human corpus luteum also during pregnancy, but they are saturated by endogenous hCG. Evidence for this was obtained by elution of hCG with 0.15M sodium chloride at pH 2.3 from washed plasma membrane fractions of luteal tissue from six to 16 week's gestation. After acid treatment and neutralization these preparations showed specific binding for 125I-labeled hCG, but not for 125I-labeled hLH. Our results demonstrate a shift in the balance of affinity of the gonadotropin receptor from hLH to hCG during the course of luteal phase, and during pregnancy the binding sites appear to be available for hCG only." @default.
- W1862207360 created "2016-06-24" @default.
- W1862207360 creator A5013796497 @default.
- W1862207360 creator A5032244442 @default.
- W1862207360 creator A5047995968 @default.
- W1862207360 creator A5056382994 @default.
- W1862207360 date "1978-08-01" @default.
- W1862207360 modified "2023-10-16" @default.
- W1862207360 title "Gonadotropin receptors of human corpus luteum during menstrual cycle and pregnancy" @default.
- W1862207360 cites W1563193952 @default.
- W1862207360 cites W1610439870 @default.
- W1862207360 cites W1712681742 @default.
- W1862207360 cites W1775749144 @default.
- W1862207360 cites W1893651774 @default.
- W1862207360 cites W1983649348 @default.
- W1862207360 cites W1987038259 @default.
- W1862207360 cites W1997803428 @default.
- W1862207360 cites W2030434743 @default.
- W1862207360 cites W2048833274 @default.
- W1862207360 cites W2050130152 @default.
- W1862207360 cites W2052790041 @default.
- W1862207360 cites W2084808560 @default.
- W1862207360 cites W2088828363 @default.
- W1862207360 cites W2089742346 @default.
- W1862207360 cites W2165245645 @default.
- W1862207360 cites W46331723 @default.
- W1862207360 doi "https://doi.org/10.1016/0002-9378(78)90235-1" @default.
- W1862207360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/210668" @default.
- W1862207360 hasPublicationYear "1978" @default.
- W1862207360 type Work @default.
- W1862207360 sameAs 1862207360 @default.
- W1862207360 citedByCount "40" @default.
- W1862207360 countsByYear W18622073602021 @default.
- W1862207360 crossrefType "journal-article" @default.
- W1862207360 hasAuthorship W1862207360A5013796497 @default.
- W1862207360 hasAuthorship W1862207360A5032244442 @default.
- W1862207360 hasAuthorship W1862207360A5047995968 @default.
- W1862207360 hasAuthorship W1862207360A5056382994 @default.
- W1862207360 hasConcept C126322002 @default.
- W1862207360 hasConcept C134018914 @default.
- W1862207360 hasConcept C143228043 @default.
- W1862207360 hasConcept C170493617 @default.
- W1862207360 hasConcept C2775948956 @default.
- W1862207360 hasConcept C2776608385 @default.
- W1862207360 hasConcept C2778782382 @default.
- W1862207360 hasConcept C2779058012 @default.
- W1862207360 hasConcept C71315377 @default.
- W1862207360 hasConcept C71924100 @default.
- W1862207360 hasConcept C86803240 @default.
- W1862207360 hasConceptScore W1862207360C126322002 @default.
- W1862207360 hasConceptScore W1862207360C134018914 @default.
- W1862207360 hasConceptScore W1862207360C143228043 @default.
- W1862207360 hasConceptScore W1862207360C170493617 @default.
- W1862207360 hasConceptScore W1862207360C2775948956 @default.
- W1862207360 hasConceptScore W1862207360C2776608385 @default.
- W1862207360 hasConceptScore W1862207360C2778782382 @default.
- W1862207360 hasConceptScore W1862207360C2779058012 @default.
- W1862207360 hasConceptScore W1862207360C71315377 @default.
- W1862207360 hasConceptScore W1862207360C71924100 @default.
- W1862207360 hasConceptScore W1862207360C86803240 @default.
- W1862207360 hasIssue "7" @default.
- W1862207360 hasLocation W18622073601 @default.
- W1862207360 hasLocation W18622073602 @default.
- W1862207360 hasOpenAccess W1862207360 @default.
- W1862207360 hasPrimaryLocation W18622073601 @default.
- W1862207360 hasRelatedWork W1590486802 @default.
- W1862207360 hasRelatedWork W1862207360 @default.
- W1862207360 hasRelatedWork W1967558070 @default.
- W1862207360 hasRelatedWork W1986238933 @default.
- W1862207360 hasRelatedWork W2001282954 @default.
- W1862207360 hasRelatedWork W2020167192 @default.
- W1862207360 hasRelatedWork W2050130152 @default.
- W1862207360 hasRelatedWork W2077310020 @default.
- W1862207360 hasRelatedWork W2169584748 @default.
- W1862207360 hasRelatedWork W2406310073 @default.
- W1862207360 hasVolume "131" @default.
- W1862207360 isParatext "false" @default.
- W1862207360 isRetracted "false" @default.
- W1862207360 magId "1862207360" @default.
- W1862207360 workType "article" @default.